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Researchers Identifies Causes of Osteoporosis in Older Adults

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Osteoporosis
Bone loss in adults. IANS
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New York, Sep 25, 2017: Researchers have identified a mechanism that leads to bone loss in older adults, an advance that may help develop therapeutics to treat the age-associated bone loss condition.

Osteoporosis — the thinning of bone and the loss of bone density that increases the risk of fractures — is a major health problem in older people.

Often the condition is accompanied by an increase in fat cells in the bone marrow.

The study led by Yi-Ping Li, Professor at the University of Alabama at Birmingham, found a protein called Cbf-beta which plays a critical role in maintaining the bone-producing cells.

Furthermore, the examination of aged mice showed dramatically reduced levels of Cbf-beta in bone marrow cells as compared to younger mice.

The findings showed when this mechanism malfunctions, progenitor cells stop creating bone-producing cells and instead create fat cells.

Thus, maintaining this Cbf-beta may be essential to prevent human age-associated osteoporosis that is due to elevated creation of fat cells, Li said.

The results were published in the journal Proceedings of the National Academy of Sciences.

Knowledge of this mechanism can provide targets in the search for novel bone-loss therapeutics to treat human osteoporosis with minimal side effects, the researchers noted. (IANS)

 

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Do you regularly take opioids and anti-depressants? This study says it may increase bone diseases

The researchers evaluated 11,049 rheumatoid arthritis patients, aged 40 and above, with no signs of osteoporotic fractures prior to the tests. After a median follow-up time of 5.7 years, the study found 863 patients affected with osteoporotic fractures.

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Anti-depressants may increase the risk of developing bone fractures, says a new study

New York, November 6, 2017 : Consuming opioids and anti-depressants may increase the risk of developing bone fractures among people who are already suffering from rheumatoid arthritis, says a new study.

Rheumatoid arthritis is a chronic disease that causes pain, stiffness, swelling, and limitation in the motion and function of multiple joints and organs of the body.

Chronic inflammation and pain in arthritis patients further leads to several diseases like cardiovascular, mental and gastrointestinal disorders. People take multiple medications in such cases that sometimes influences the risk of osteoporotic fractures or a disease caused due to reduced bone density, the researchers noted.

ALSO READ Importance of Magnesium in Human body, Strenghtens bones

“Even at younger ages, rheumatoid arthritis is associated with a two-fold increased risk of osteoporosis and fractures due to chronic inflammation and glucocorticoid use. More importantly, osteoporotic fractures significantly contribute to the disability, health-related costs and mortality with substantially higher complication in rheumatoid arthritis patients,” said Gulsen Ozen, researcher at the University of Nebraska Medical Centre.

The researchers evaluated 11,049 rheumatoid arthritis patients, aged 40 and above, with no signs of osteoporotic fractures prior to the tests. After a median follow-up time of 5.7 years, the study found 863 patients affected with osteoporotic fractures.

The patients who developed fractures were significantly older and had higher disease risk and bone fracture risk at the baseline than those patients who did not experience fractures.

The results presented at the ACR/ARHP annual meeting 2017 in San Diego mentioned that the osteoporotic fracture risk increased within 30 days when the patients were given opioids. The associated medications also led to falls in certain cases.

“Knowing the risks associated with the use of these medications can guide rheumatologists and other physicians in choosing the most appropriate management strategies in patients, particularly the ones who have a high fracture or fall risk,” Ozen added. (IANS)

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