Sunday August 18, 2019

Researchers Identifies Causes of Osteoporosis in Older Adults

Bone loss in adults. IANS

New York, Sep 25, 2017: Researchers have identified a mechanism that leads to bone loss in older adults, an advance that may help develop therapeutics to treat the age-associated bone loss condition.

Osteoporosis — the thinning of bone and the loss of bone density that increases the risk of fractures — is a major health problem in older people.

Often the condition is accompanied by an increase in fat cells in the bone marrow.

The study led by Yi-Ping Li, Professor at the University of Alabama at Birmingham, found a protein called Cbf-beta which plays a critical role in maintaining the bone-producing cells.

Furthermore, the examination of aged mice showed dramatically reduced levels of Cbf-beta in bone marrow cells as compared to younger mice.

The findings showed when this mechanism malfunctions, progenitor cells stop creating bone-producing cells and instead create fat cells.

Thus, maintaining this Cbf-beta may be essential to prevent human age-associated osteoporosis that is due to elevated creation of fat cells, Li said.

The results were published in the journal Proceedings of the National Academy of Sciences.

Knowledge of this mechanism can provide targets in the search for novel bone-loss therapeutics to treat human osteoporosis with minimal side effects, the researchers noted. (IANS)


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Probiotics Can Halve Risk of Bone Loss in Elderly Women

Worldwide, one in three women over the age of 50 will experience osteoporotic fractures, as will one in five men over the same age

Ovarian Cancer
At least 100 million women worldwide use hormonal contraception every day. . (IANS)

Apart from keeping your gut healthy, consuming a diet rich in probiotics — also called as “good” or “helpful” bacteria — may cut the risk of osteoporosis, an age-related bone loss condition that causes fractures among one in three women over age 50 worldwide, finds a study.

In the study, older women who received probiotics, the risk of bone loss was halved compared to women who received only a placebo.

“Older women are at risk the most of osteoporosis and fractures. Treatment with probiotics can be an effective and safe way to prevent the onset of osteoporosis in many older people in the future,” said Mattias Lorentzon, Professor at the University of Gothenburg, Sweden.

Brittleness of the bones, or osteoporosis, is characterised by porous and weak bones, which can cause them to break even when subjected to low loads, such as a fall from a standing height.

According to the International Osteoporosis Foundation, the condition causes more than 8.9 million fractures annually, resulting in an osteoporotic fracture every three seconds.

bone loss
Representational image.

Worldwide, one in three women over the age of 50 will experience osteoporotic fractures, as will one in five men over the same age.

The findings, published in the Journal of Internal Medicine, also opens the door to a new way to prevent fractures among the elderly.

For the study, the team ingested a powder that contained either Lactobacillus reuteri 6475 bacteria — health-promoting bacteria — or a placebo every day for a whole year in nearly 100 elderly women, 76 years old on average.

Also Read: Probiotics Not Effective in Reducing Anxiety: Study

The women who received the powder with active bacteria had lost only half as much bone in the skeleton compared with those who received inactive powders.

“Another positive outcome from the study was that the treatment was well tolerated and did not produce more side effects than those experienced by women who received the placebo,” the researchers noted. (IANS)