Tuesday, July 14, 2020
Home Life Style Health & Fitness Researchers Identify 102 Genes Associated with Autism

Researchers Identify 102 Genes Associated with Autism

It's critically important that families of children with and without autism participate in genetic studies because genetic discoveries are the primary means to understanding the molecular, cellular, and systems-level underpinnings of autism

In the largest genetic sequencing study of autism spectrum disorder (ASD) to date, researchers have identified 102 genes associated with risk for autism.

The discovery shows significant progress towards teasing apart the genes associated with autism from those associated with intellectual disability and developmental delay, conditions which often overlap.

According to the World Health Organisation (WHO), one in 160 children has an autism spectrum disorder (ASD).

ASDs begin in childhood and tend to persist into adolescence and adulthood. In most cases the conditions are apparent during the first five years of life.

“This is a landmark study, both for its size and for the large international collaborative effort it required.

“With these identified genes we can begin to understand what brain changes underlie ASD and begin to consider novel treatment approaches,” said Joseph D Buxbaum, Director of the Seaver Autism Center for Research and Treatment at Icahn School of Medicine at Mount Sinai.

For the study published in the journal Cell, an international team of researchers from more than 50 sites collected and analyzed more than 35,000 participant samples, including nearly 12,000 with ASD, the largest autism sequencing cohort to date.

Autism
Families of children with autism face high physical, mental and emotional burdens, are sometimes ridiculed and even accused of child abuse, says a new study. Pixabay

Using an enhanced analytic framework to integrate both rare, inherited genetic mutations and those occurring spontaneously when the egg or sperm are formed, researchers identified the 102 genes associated with ASD risk.

Of those genes, 49 were also associated with other developmental delays.

The larger sample size of this study enabled the research team to increase the number of genes associated with ASD from 65 in 2015 to 102 today.

In addition to identifying subsets of the 102 ASD-associated genes, the researchers showed that ASD genes impact brain development or function and that both types of disruptions can result in autism.

“Through our genetic analyses, we discovered that it’s not just one major class of cells implicated in autism, but rather that many disruptions in brain development and in neuronal function can lead to autism,” said Buxbaum.

Also Read: Vaping May not Help with Smoking Cessation: Report

It’s critically important that families of children with and without autism participate in genetic studies because genetic discoveries are the primary means to understanding the molecular, cellular, and systems-level underpinnings of autism.

“We now have specific, powerful tools that help us understand those underpinnings, and new drugs will be developed based on our newfound understanding of the molecular bases of autism,” the researchers noted. (IANS)

STAY CONNECTED

18,985FansLike
362FollowersFollow
1,786FollowersFollow

Most Popular

Only 3% Indians Realize the Importance of Adequate Protein Diet

Although 95 percent of Indian mothers claim to know protein as a macro-nutrient, only three percent of the population really understands the prominent functions...

Here’s Why Pregnant Women Should be Beware of UTIs

Although the monsoon brings respite from summer's scorching heat, it also invites a plethora of allergies and infections. Pregnant women should be cautious because...

International Mandela Day: Following Madiba’s Footsteps

While the mention of South Africa immediately brings alive the imagery of safaris, glamping, bungee jumping, diverse food, and warm people, its rich and...

The 5 Undeniable Reasons for Purchasing HGH

Are you tired of the endless disappointment that comes with trying numerous diet pills and diet programs? Don't worry, and you aren't alone. Most...

This Facebook Robot Walks On Power Lines To Install Fiber-Optic Cable

Facebook has developed an aerial fiber deployment solution that uses a robot to safely deploy a specialized fiber-optic cable on medium-voltage (MV) power lines...

In Conversation With Dr. Chandra Shekhar Mayanil on Yog, Dhyan and Hinduism

Dr. Chandra Shekhar Mayanil is a Neuroscientist who is currently living in Naperville, Illinois. He has a very profound knowledge about yog, dhyan and...

Cloud Kitchens in India: A New Normal

There is a certain distinction in the concept and coinage of the term 'cloud kitchen'; the concept of takeaway or delivery only, without dining,...

Ayushmann Khurrana on How He Chooses Films

Ayushmann Khurrana says he has always opted for films that have no reference point and that he has done so deliberately. Follow us on Instagram to...

Recent Comments