Monday, August 10, 2020
Home Life Style Health & Fitness Researchers Identify Key Protein that Spurs Bowel Cancer Growth

Researchers Identify Key Protein that Spurs Bowel Cancer Growth

Learning more about how Importin-11 transports beta-catenin into the nucleus may help researchers develop new therapies that block this process and reduce the growth of colorectal cancers caused by mutations in APC

Researchers have identified a key protein that supports the growth of many bowel cancers, paving the way for development of new therapies to combat the deadly disease.

The study, published in the Journal of Cell Biology, revealed that a protein called Importin-11 transports the cancer-causing protein beta-catenin into the nucleus of colon cancer cells, where it can drive cell proliferation.

Inhibiting this transport step could block the growth of most colorectal cancers — also called bowel cancers — caused by elevated beta-catenin levels.

Around 80 per cent of colorectal cancers are associated with mutations in a gene called APC that result in elevated levels of the beta-catenin protein.

This increase in beta-catenin is followed by the protein’s accumulation in the cell nucleus, where it can activate numerous genes that drive cell proliferation and promote the growth and maintenance of colorectal tumours.

But how beta-catenin enters the cell nucleus after its levels rise is poorly understood.

Gut Bacteria
Researchers have found that people with a certain type of Gut Bacteria may be at a greater risk of developing bowel cancer. Pixabay

“Because the molecular mechanisms underlying beta-catenin nuclear transport remain unclear, we set out to identify genes required for continuous beta-catenin activity in colorectal cancer cells harbouring APC mutations,” said Stephane Angers, Professor at the University of Toronto in Canada.

Using CRISPR DNA editing technology, the researchers developed a new technique that allowed them to screen the human genome for genes that support beta-catenin’s activity in colorectal cancer cells after its levels have been elevated by mutations in APC.

Angers and colleagues found that Importin-11 binds to beta-catenin and escorts it into the nucleus of colorectal cancer cells with mutations in APC. Removing Importin-11 from these cells prevented beta-catenin from entering the nucleus and activating its target genes.

The researchers discovered that Importin-11 levels are often elevated in human colorectal cancers. Moreover, removing Importin-11 inhibited the growth of tumours formed by APC mutant cancer cells isolated from patients.

Also Read: Samsung Likely to Release ‘Clamshell’ Foldable Phone in February

“We conclude that Importin-11 is required for the growth of colorectal cancer cells,” Angers said.

Learning more about how Importin-11 transports beta-catenin into the nucleus may help researchers develop new therapies that block this process and reduce the growth of colorectal cancers caused by mutations in APC. (IANS)

STAY CONNECTED

18,958FansLike
362FollowersFollow
1,782FollowersFollow

Most Popular

Redecorating Your Home Amid Pandemic

By Puja Gupta After coping with the sudden disruption caused by the lockdown, families across India are now settling down to make the best of...

94% People Feel Happier When Outdoors: Survey

By SIddhi Jain Social distancing norms is the ''new normal" and it has the world spending more time indoors than ever, but a new survey...

Assisted Living Homes and Their Importance for Elderly People

By Siddhi Jain Shrinking family sizes, lack of awareness about age-related conditions and availability of specialised care homes for the elderly are some of the...

Understand the Procedure and Importance of IVF

By Puja Gupta According to WHO, every 1 in 8 couples (or 12 per cent of married women) has gone through complexities getting pregnant or...

Try These Recipes to Get Super Charged with Nutrients you Need

By Simrun Chopra 2020 is unlike any year we have seen and in parts of the country this monsoon is unlike any we have seen. Staying...

Sidharth Malhotra has Felt a Wide Range of Emotions this Year

Actor Sidharth Malhotra has felt a wide range of emotions over the past few months. When the year 2020, started, he enjoyed some relaxing time,...

How Relevant Is The Existence Of Censor Board Of Film Certification?

There is a curious situation vis a vis the Censor Board of Film Certification! How relevant is its existence now? The Board, which was...

Vidyut Jammwal Reveals Secret of his Upper Body Strength in a Video

Action star and fitness enthusiast Vidyut Jammwal has revealed the secret of his upper body strength. Vidyut has uploaded a video of him performing Kalari...

Recent Comments