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A team of Indian-American researchers at the University of Illinois at Urbana-Champaign (UIUC) and at the University of Utah at Salt Lake City, has used an ingenious process to enable curcumin to kill cancer cells.
Curcumin is the active ingredient of turmeric (haldi), the ubiquitous kitchen spice that gives curry its yellow color. Turmeric has been used in India for thousands of years as a spice and medicinal herb because of its powerful anti-inflammatory and strong antioxidant property.
Curcumin is also known to exhibit anti-cancer properties, but its poor solubility in water had impeded curcumin’s clinical application in cancer. A drug needs to be soluble in water as otherwise it will not flow through the bloodstream.
Despite decades of research, the development of efficient strategies that can effectively deliver poorly water-soluble curcumin to cancer cells had remained a challenge.
A team headed by Dipanjan Pan, associate professor of bioengineering at UIUC, has now found a way out.
“Curcumin’s medicinal benefit can be fully appreciated if its solubility issue is resolved,” Pan told this correspondent in an e-mail.
Pan’s laboratory collaborated with Peter Stang at the University of Utah on ways to be able to render curcumin soluble, deliver it to infected tumors and kill the cancer cells.
Because platinum is a commonly used cancer therapeutic agent in the clinic, the researchers decided to experiment with a drug consisting of a combination of platinum and curcumin.
“It is a combination of clever chemistry and nano-precipitation utilising host guest chemistry,” Pan explained. “The sophisticated chemistry leads to self-assembled hierarchical structure that drives the solubility of curcumin and simultaneously delivers an additional anticancer agent, i.e. platinum. The combined therapeutic effect — of curcumin and platinum — is lethal for the cancer cells.”
The team has reported its work in the “Proceedings of the National Academy of Sciences” in the US.
According to their report, the metallocyclic complex created using platinum “not only enabled curcumin’s solubility, but proved to be 100 times more effective in treating various cancer types such as melanoma and breast cancer cells than using curcumin and platinum agents separately”.
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“Our results demonstrate that curcumin works completely in sync with platinum and exerts synergistic effect to show remarkable anticancer properties,” says the report. “The platinum-curcumin combination kills the cells by fragmenting its DNA.”
“Extensive animal studies are in progress in my laboratory, including in rodents and pigs,” Pan said. His team also hopes to prove that this method will be effective in killing cancer stem cells — the birth place of cancer cells — thereby preventing the recurrence of cancer.
Pan’s team included post-doctoral researcher Santosh Misra at UIUC, and Sougata Datta, Manik Lal Saha, Nabajit Lahiri, Janis Louie, and Peter J. Stang from the University of Utah. (IANS)
The US was the world's "top generator of plastic waste" in 2016, exceeding all European nations combined, The Hill reported recently.
An article, entitled "US must cut plastic production to save oceans," was published on Wednesday, citing a new study by the National Academy of Sciences.
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With a population of about 330 million, accounting for only 4.3 per cent of earth's population, the US generates a total of 42 million metric tons of such waste in 2016, the report said.
"The waste is devastating the ocean's health and marine wildlife," it reported.
"Plastic waste is an environmental and social crisis that the US needs to affirmatively address from source to sea," Margaret Spring, chair of the committee behind the report was quoted as saying in The Hill's article.
Plastic is a valuable resource that should be kept in our economy and out of our environment.Unsplash
Also read: Humans are covering Earth with Plastic
However, the American Chemistry Council (ACC) - a trade group that represents 28 companies, including oil giants, major chemical manufacturers and plastic makers - slammed the study's recommendation that plastic production should be limited, Xinhua news agency reported.
Joshua Baca, Vice President of plastics at the ACC, was quoted by the report as saying that "plastic is a valuable resource that should be kept in our economy and out of our environment."(IANS/PR)
(Keywords: US, Largest Plastic generator, Waste)
Last Thursday, the Dogs of Elon (DOE) currency surged by more than 25% before plunging later that day. Dogs of Elon is a collection of Ethereum-based non-fungible tokens (NFTs) featuring a variety of everyone's favorite crypto dog, as well as a few strange Elons and zombie Doges.
The collection is available on Opensea, while the DOE token is available on Uniswap and a few other exchanges. Because DOE is a proof-of-stake token, users may stake their tokens and immediately get rewards.
The Dogs of Elon team indicated that on December 1, they will hold a draw for a Tesla Model 3 worth $50,000 in Ethereum (ETH), with winners chosen at random and publicized that day. You must either own a Dogs of Elon NFT or have at least 500 DOE tokens to participate.
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Additionally, the team is developing a play-to-earn DOE game. This game, like Atari's renowned Spaceship game, requires players to shoot enemy Spaceships in order to progress through the levels. The development of a blockchain-based play-to-earn game has the potential to boost Dogs of Elon's value to an all-time high.
Gamified crypto projects have garnered considerable interest in the cryptosphere. At the moment, Axie Infinity, Crypto blades, and Mist are among the finest. They all have one feature, however: they are much too sophisticated for the average player to handle. That is when Doge Dash attempts to grasp the moment. Doge Dash is a tribute to the original Mario sidescroller.
Also Read: Use These Tools to Calculate Your Crypto Tax
Players may earn coins at each of the game's 10 levels by demonstrating their gaming ability or by contributing to the environment. If a player successfully completes all levels, all coins earned will be credited to their connected wallet.
Doge Dash's difficulty level grows as you go through the game's several levels. To complete the game, you must navigate a metropolis invaded by zombies and other creatures.
Doge Dash's mission is to build a library of NFT skins for usage in the game. Additionally, their team will endeavor to expand the NFT collection, recruit new influencers, and promote the asset's adoption. HUH Token is another Token that is successfully using a similar strategy.
The HUH Token white paper has been released.
HUH Token seems to be aiming to be the most transparent and open blockchain project possible. Members of the community are having a significant influence via social media and Telegram. The project is also progressing well, and the token will be released on Monday!
The HUH Token is a "Utimeme" that aims to combine the incredible potential of social cultivation with the functionality of NFT platforms and the scalability of a smart contract in order to produce a genuinely innovative product.
The HUH Token white paper has been released, which it aids in the construction of the brand's objectives and functions. The presale for the HUH Token is over and the token is now available. The project has already received a record-breaking amount of deposits.
Additionally, it has an innovative, intelligent chain-based recommendation engine, in addition to a sizable social following. Through the use of a code issued at the time of purchase, the purchaser of the HUH Token may recommend an unlimited number of persons who do not currently own a HUH Token to buy one. More information on these tokenomics can be found in the whitepaper and on HUH Tokens website.
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Twitter: https://twitter.com/HuhTokenInstagram: https://www.instagram.com/huhToken/
(Disclaimer: This article is sponsored and includes some commercial links.)
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Launch days can be especially turbulent, but none more than in the cryptocurrency market, especially for the cryptocurrencies that are going to be rivalled for supremacy.
HUH Token’s launch today saw Dogecoin worry for their top spot status, but you might be wondering why the world’s first ‘Utimeme’ was able to achieve that response from Dogecoin.
This article is going to explain how HUH Token’s launch today did more than enter the cryptocurrency market and how the could have affected Dogecoin in unseen ways by crypto lovers.
Dogecoin Rivalled by a Worthy Opponent
Dogecoin had really only been rivalled by Shiba Inu in august of 2020 because Shiba Inu harnessed something that Dogecoin had missed, or at least, hadn’t conidered would be used against them on the cryptocurrency market… this was the power of influence and Shiba Inu used it to trounce Dogecoin all those months ago.
It appears that Shiba Inu also share that same lack of foresight given HUH Token’s popularity before today and on it’s current launch day (Happy Launch Day HUH Token!). The lacking of Dogecoin and Shiba Inu is that a cryptocurrency (HUH Token) would launch a Utimeme.
HUH Token’s Utimeme, the only worthy opponent of Dogecoin, is a token that uses the power of influence (meme coin) with the usability of utility coins (Ethereum).
Here, on Monday December 6th, HUH Token launched on to the cryptocurrency market and it made more than a splash especially with the future plans of HUH Token for instance its MetHUH and you can read more about that in HUH Token’s White Paper.
HUH? Worthy for You Too?
Though it’s all good and well that HUH Token can rival the big dogs but what does HUH Token mean for you and to you and what do you mean to HUH?
A bit of a mouthful? Maybe not, because one of HUH Token’s main aims is to keep generations of HUH Token holders, HUH Nation member and MetHUH community member mouths full.
This could be achieved through numerous lines of technology application HUH Token have set out but mostly with their smart contracts, multichain use and LP acquisition which is set to increase liquidity over time.
HUH Token’s heart is you because a community is nothing without its people.
HUH Token are set to take the crypto world by storm.
There might be no sweeter words to mine and crypto lovers and newbies ears today on HUH Token’s launch.
Because, well, it’s HUH Token’s launch, baby!
I might sound overly excited about that, but like you, I’ve been following the presale state of HUH Token with a fixed eye and their launch day has been at the front of my mind for weeks.
One of the reasons that I, along with most of the crypto world, have been excited for HUH Token’s launch day (today) is because HUH Nation is growing and that benefits everyone who’s a holder of HUH Token.
HUH Token are set to take the crypto world by storm and given HUH Token could be the only worthy opponent of Dogecoin, today and in the future.
If this article has whetted your lips for all things HUH Token, then you can check them out now and revel in the buzz of the much awaited HUH Token Launch.
Again, Happy Launch Day HUH Token, we might just have been waiting for some-crypto like you.
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(Disclaimer: This article is sponsored and includes some commercial links.)