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In a new hope for cancer patients, researchers have found a way to cause some cancer cells to self-destruct.
The research team has identified a new pathway that works as a partner to a gene called MYC which controls normal cell growth, but when it is mutated or amplified in cancer, it sets off a chain reaction that helps tumours grow uncontrollably.
The pathway involves a protein called ATF4, and when it’s blocked, it can cause cancer cells to produce too much protein and die.
Published in the journal Nature Cell Biology, the study done on mice points the way towards a new therapeutic approach as inhibitors that can block synthesis of ATF4 already exist.
“What we’ve learned is that we need to go further downstream to block tumour growth in a way that cancer cells can’t easily escape, and our study identifies the target to do just that,” said Constantinos Koumenis, Professor at the University of California.
According to researchers, this finding shows the alternative approach is to target ATF4 itself, since it’s the point where both signal pathways converge, meaning there’s less redundancy built in to allow cancer to survive.
It also shows that ATF4 turns on the genes MYC needs for growth and also controls the rate at which cells make specific proteins called 4E-BP.
This study also found that when tumours in humans are driven by MYC, ATF4 and its protein partner 4E-BP are also overly expressed, which is further evidence that these findings may point to an approach that could work for humans. (IANS)
Meta-owned photo-sharing platform Instagram has started testing subscriptions, a new feature allowing creators to offer paid followers access to exclusive content. Currently, only 10 US creators have gained access to the new feature, including basketball player Sedona Prince, model Kelsey Cook, actor-influencer Alan Chikin Chow, Olympic gymnast Jordan Chiles and digital creator Lonnie IIV.
"Subscriptions are for creators," Instagram chief Adam Mosseri said in a video posted on Twitter. "Creators do what they do to make a living and it's important that it is predictable." Followers will pay a monthly fee to access subscriber-only content from creators they follow. Subscription pricing ranges from $0.99 per month to $99.99 per month.
Instagram users who subscribe to a creator will have access to subscriber-only stories, live streams, and other content. | Photo by Claudio Schwarz on Unsplash
Instagram users who subscribe to a creator will have access to subscriber-only stories, live streams, and other content. Meanwhile, Instagram is also reportedly testing Stories redesign with vertical scrolling in its app. As noted by social media consultant Matt Navarra, some users located in Turkey have received an Instagram update that brings vertical scrolling to Stories.
While Stories from the same user can still be viewed by tapping the left or right side of the screen, jumping to the next user's Stories requires a swipe down. (IANS/ MBI)
(Keywords: subscriber, feature, testing, Instagram, followers, scrolling, users, content creators, stories)
Many stray animals are trying to survive as the temperature in the capital continues to drop. Many strays lose this battle trying to find food and warmth under a scrap of clothing or caged up in the corner of streets. The Perroayuda Welfare Foundation (PWF), a Delhi-based animal welfare organisation, recently held a Mega Stray Feeding Drive in Lajpat Nagar with the goal of feeding all of the area's stray animals. These wonderful Samaritans come from all around Delhi-NCR with one goal in mind: to rescue, feed, and adopt all animals in need.
Many stray animals are trying to survive as the temperature in the capital continues to drop. | Af.Mil
PWF has previously staged feeding drives in Netaji Subhash Place, Connaught Place, North Campus, Delhi University, and other locations throughout the city. A group of 70 volunteers fed over 100 stray dogs in the vicinity and provided water in earthen bowls. To raise awareness about the issue of stray animals, volunteers talked with businesses, local authorities, customers, and hawkers. The actions of this group of young animal advocates were recognised and supported.
"Donations come in from all around the world." To save strays and pay for their treatment, we rely completely on donations. "Every day, our organisation feeds roughly 1000 stray dogs," says Arpit Mathur, the organisation's founder. "Throughout the day, we receive SOS calls. We can only accomplish so much with our limited staff and resources. We hope that more young people, like us, would join us in this cause." In Rohini, the NGO also maintains a recovery centre. Currently, the recovery centre accommodates roughly 40 animals, including cats, dogs, monkeys, and a few unusual birds.
To rescue, feed, and adopt all animals in need is the goal of these people. | Photo by Camilo Fierro on Unsplash
PWF seeks to discover and feed all stray animals in need, as well as provide them with food, care, affection, and medical treatment, and organise Mega Stray Feeding Drives to raise awareness and adoption. "We discover stray animals, pet them, and feed them - no one deserves to be hungry," Mathur adds. (IANS/ MBI)
(Keywords: adopt, feed, rescue, goal, Delhi-NCR, Perroayuda Welfare Foundation, Winter, stray animals, Help, Initiative, volunteer)
Indonesian lawmakers passed a law on the relocation of the nation's capital to the island of Kalimantan, which shares borders with Malaysia and Brunei, from the most populated island of Java. The move is a step forward in one of the most ambitious projects initiated by the country's President Joko Widodo, Xinhua news agency reported. Some former presidents had floated ideas of relocating the capital city in the past. The president, widely known as Jokowi, three years ago vowed to relocate the capital city to the province of East Kalimantan due to a number of issues like high population density and land subsidence in Jakarta which is home to more than 10 million people.
Indonesian lawmakers passed a law on the relocation of the nation's capital. Aditya Joshi / Unsplash
Nusantara, which the new capital is called, will be built in two districts in East Kalimantan -- Penajam Paser Utara and Kutai Kartanegara. It is set to occupy about 256,000 hectares of land. The name of Nusantara, which can be translated as an archipelago in English, was chosen by President Jokowi, Minister for National Development Planning Suharso Monoarfa has said. Indonesia, the world's fourth most populous country, is home to some 270 million people, consisting of about 17,000 islands. "The national capital has a central function and serves as a symbol of a country to show the identity of the nation and state," Minister Monoarfa explained during a meeting with lawmakers at the House of Representatives on Tuesday.
Also Read : Hinduism in Indonesia
The ground-breaking of the construction project that is slated to cost $32 billion was initially expected to be conducted in August 2020, but the Covid pandemic has forced the government to put it on hold. Some of the projects on the construction of the new capital will be carried out by public-private partnerships, and the early stage of the relocation will begin this year and is expected to end in 2024. At this stage, the government will build a presidential palace, parliament buildings, and a housing complex in the primary zone. The move of civil servants at the early stage must be completed before August 16, 2024.
The construction project is slated to cost $32 billion.Sulthan Auliya / Unsplash
Nusantara will serve as the centre of government, while Jakarta would remain the business and economic centre of Indonesia, Southeast Asia's biggest economy. A day before the lawmakers passed the bill, President Jokowi stressed that that new capital is not only about physically relocating the offices of government institutions, but also "building a new smart city." It has been reported that Nusantara will be headed by an authority chief appointed by the president and its level of position is equal to a minister. Several former government officials which will likely become the chief include Jakarta's former governor Basuki Tjahaja Purnama and former minister for research and technology Bambang Brodjonegoro. (IANS/SP)
(Keywords : Indonesia, Parliament, law, relocate, capital, Nusantara, Jakarta, government, Kalimantan, President, country, people, meeting, construction, palace, buildings, housing, officials.)
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