Monday February 24, 2020

Treatment with Uterine Fibroids helps restoring Fertility in Women

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Fertility restoring proceedure
According to a study, women can restore their fertility by simply undergoing a minimal invasive treatment with uterine fibroids. VOA
  • Women can restore their fertility by simply undergoing a minimal invasive treatment with uterine fibroids (UFE)
  • UFE can be performed in patients with a prior myomectomy or In Vitro Fertilization (IVF)
  • “In our study there are now almost 200 newborns following UFE,” Dr. Pisco said

USA, June 13: If you wish to enter the motherhood and are pregnant with a thought of bearing a child but infertility creates hurdles for you, then here is a study which will prove a boon to you.

According to a study, women can restore their fertility by simply undergoing a minimal invasive treatment with uterine fibroids. These smooth muscle tumors of the uterus are majorly responsible for infertility in women consequently creating bottlenecks and complications in the pregnancy.

The study suggests a treatment through ‘Uterine fibroid embolization’ (UFE). It involves an injection of an embolic agent which is basically prepared by tiny beads. This injection makes its way into the uterine arteries and cuts away the blood supply to the fibroids and uterus. When the blood supply is blocked, fibroids begin fading away by contracting and shrinking. As a result uterus begins to prosper again.

Removing these fibroids through surgery or myomectomy is also an option to revive fertility in women. But as per stated by study co-author Joao Martins Pisco, with myomectomy comes other complications such as hysterectomy.

“Our findings show that UFE is a fertility-restoring procedure in women with uterine fibroids, who wish to conceive and pregnancy following UFE appears to be safe with low morbidity,” Dr. Pisco said.

ANI news reported: “UFE can be performed in patients with a prior myomectomy or In Vitro Fertilization (IVF)”.

A test was conducted on 359 women who were not capable of conceiving due to the uterine fibroids. They underwent the UFE treatment. It was seen as a result that out of 359 women, 149 (41.5%) were able to bear children one or more than one time in the span of almost six years.  It is also important to note that 131 women give birth to about 150 babies in total. What excites more is the fact that it was for the first time for more than 85 percent of the women to enter their motherhood.

It has been further informed that the procedure was successful in 79 percent of the cases and in removing fibroid-related symptoms. However, there were complications too accounting to approximately 14.6 percent for partial UFE and 23.1 for conventional UFE.

“In our study there are now almost 200 newborns following UFE,” Dr. Pisco said.

– prepared by Himanshi Goyal of Newsgram, Twitter: @himanshi1104

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Reflux Drug Can Be a Promising Therapy To Curb Preterm Birth: Study

The researchers identified 83 drug candidates, but when they excluded those found to have pregnancy risks in animal or human studies

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Pregnancy
Inflammation clearly plays a role in initiating labour and preterm birth. Immune pathways are very significantly dysregulated in women who end up delivering preterm, and they're also dysregulated in babies who are born early. Pixabay

Researchers have found that Lansoprazole, an over-the-counter acid reflux drug that is often taken by pregnant women, may be a promising therapy to reduce preterm birth.

The study, published in the journal JCI Insight also identified 12 other USFDA-approved drugs that are deemed safe in pregnancy. While the drugs encompass a variety of modalities, the researchers said they all appear to act on biological pathways that affect the immune response, which is implicated in preterm birth.

“Inflammation clearly plays a role in initiating labour and preterm birth. Immune pathways are very significantly dysregulated in women who end up delivering preterm, and they’re also dysregulated in babies who are born early,” said said study senior author Marina Sirota from University of California.

“However, we have seen from our previous work that there is an interaction between the maternal and fetal immune systems and a breakdown in maternal-fetal tolerance,” Sirota added. To identify candidate drugs that might be effective in preventing preterm birth, the researchers first looked at which genes were up- or down-regulated in the blood cells of women who experienced spontaneous preterm birth to identify a gene expression “signature.”

Then they looked for the opposite signature in cells that had been exposed to 1,309 different drugs, reasoning that if a drug could correct the effects that preterm birth had on the women’s blood cells, the drugs might also prevent preterm birth itself.

The researchers identified 83 drug candidates, but when they excluded those found to have pregnancy risks in animal or human studies, they wound up with 13 drugs, ranked according to their “reversal score,” a measure of the extent to which they were able to reverse the gene expression signature of preterm birth.

The scientists chose lansoprazole for further testing because, in addition to its high reversal score, it is available over the counter, and they know from their previous work that it affects a stress-response protein, heme oxygenase-1, that has been linked with pregnancy disorders.

Lansoprazole, which is a proton-pump inhibitor marketed as Prevacid, had the second-highest reversal score of the 13 drugs identified as being safe and effective. Progesterone was further down the list. The researchers tested lansoprazole in pregnant mice that had been given a bacterial component to induce inflammation, which causes some fetuses to die in utero, where they are reabsorbed.

Pregnancy
Researchers have found that Lansoprazole, an over-the-counter acid reflux drug that is often taken by pregnant women, may be a promising therapy to reduce preterm birth. Pixabay

When these mice were given lansoprazole, they had more viable fetuses. Lansoprazole also worked better in these mice than progesterone. Although it is a good measure of how inflammation affects pregnancy in mice, the researhers said the fetal resorption mouse model is not an adequate model of human preterm birth.

They said more work, including studies in people, would need to be done before lansoprazole or any of the dozen other drugs they identified could be proven effective in pregnant women at risk for preterm birth.

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“This, basically, is a proof of concept that this drug has anti-inflammatory properties, which are not the properties the drug was designed for, this is a short way to get to new therapeutics for known diseases,” said study author David K Stevenson. (IANS)