Tuesday July 23, 2019

Risk of Cervical Cancer Highest in Middle-aged Indian Women

" While PAP test is much more likely to miss precancerous cervical disease, HPV testing is more sensitive for detecting localised infection and marginally less sensitive for distant infection," Das noted

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Cancer
Cancer Ribbon. Pixabay

Nearly 50 per cent of middle-aged women in India were found to have positive cases of high-risk human papillomavirus (HPV) — the main risk factor for cervical cancer, says a report from SRL Diagnostics.

Human papilloma virus (HPV) is a group of viruses that are extremely common worldwide. There are more than 100 types of HPV, of which at least 14 are cancer-causing (also known as high risk type).

The virus is mainly transmitted through sexual contact and most people are infected with HPV shortly after the onset of sexual activity.

Two HPV types (16 and 18) cause 70 per cent of cervical cancers and precancerous cervical lesions.

Analysis of HPV test reports of 4,500 women pan-India between 2014 and 2018, showed that women aged between 31 and 45 years had the highest percentage of high-risk HPV at 47 per cent.

This was followed by 30 per cent of women aged between 16 and 30 years being affected by the risk.

Cancer survivor, flickr

Cervical cancer accounts for one-third of all global deaths, with 74,000 deaths occurring annually and is the second leading cause of cancer deaths among women in India.

However, “cervical cancer is also the only cancer which is preventable if care is taken in the initial stage”, said B.R Das from SRL Diagnostics in a statement issued here on Saturday.

“The high mortality rate from cervical cancer globally could be reduced through a comprehensive approach that includes screening, early diagnosis and treatment programmes,” he added.

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Besides vaccination before girls become sexually active, secondary prevention can be done by regular cervical smear of PAP smear which can pick up any abnormal cells in the cervix before they become cancerous.

“While PAP test is much more likely to miss precancerous cervical disease, HPV testing is more sensitive for detecting localised infection and marginally less sensitive for distant infection,” Das noted. (IANS)

Next Story

Researchers Find Way to Make Cancer Cells Self-destruct

It also shows that ATF4 turns on the genes MYC needs for growth and also controls the rate at which cells make specific proteins called 4E-BP

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Cancer, Patients, Invasive
Traditional treatments often include chemotherapy or radiation to kill cancer cells and shrink tumors. Pixabay

In a new hope for cancer patients, researchers have found a way to cause some cancer cells to self-destruct.

The research team has identified a new pathway that works as a partner to a gene called MYC which controls normal cell growth, but when it is mutated or amplified in cancer, it sets off a chain reaction that helps tumours grow uncontrollably.

The pathway involves a protein called ATF4, and when it’s blocked, it can cause cancer cells to produce too much protein and die.

Published in the journal Nature Cell Biology, the study done on mice points the way towards a new therapeutic approach as inhibitors that can block synthesis of ATF4 already exist.

Cancer
Cancer Ribbon. Pixabay

“What we’ve learned is that we need to go further downstream to block tumour growth in a way that cancer cells can’t easily escape, and our study identifies the target to do just that,” said Constantinos Koumenis, Professor at the University of California.

According to researchers, this finding shows the alternative approach is to target ATF4 itself, since it’s the point where both signal pathways converge, meaning there’s less redundancy built in to allow cancer to survive.

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It also shows that ATF4 turns on the genes MYC needs for growth and also controls the rate at which cells make specific proteins called 4E-BP.

This study also found that when tumours in humans are driven by MYC, ATF4 and its protein partner 4E-BP are also overly expressed, which is further evidence that these findings may point to an approach that could work for humans. (IANS)