Sunday November 17, 2019

Risk Of Low BMD Among Women With Less Sleep

Little sleep is linked with risk of having low bone mineral density

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Women with less sleep have a negative impact on their bone health. Pixabay

Getting too little sleep is linked with a higher risk of having low bone mineral density (BMD) and developing osteoporosis, researchers have warned.

Osteoporosis is a disease in which bone weakening increases the risk of a broken bone.

“Our study suggests that sleep may negatively impact bone health, adding to the list of the negative health impacts of poor sleep,” said the study lead author Heather Ochs-Balcom, from the University at Buffalo in the US.

In the study of 11,084 postmenopausal women, those who reported sleeping five hours or less per night had lower BMD at all four sites assessed — whole body, total hip, neck, and spine — compared with women who reported sleeping seven hours per night.

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Women who sleep five hours or less had 22 per cent and 63 per cent higher risks of experiencing low bone mass. Pixabay

After adjustments, women reporting five hours or less per night had 22 per cent and 63 per cent higher risks of experiencing low bone mass and osteoporosis of the hip, respectively.

Similar results were seen with the spine.

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“I hope that it can also serve as a reminder to strive for the recommended seven or more hours of sleep per night for our physical and mental health,” Ochs-Balcom said.

The study was published in the Journal of Bone and Mineral Research. (IANS)

 

Next Story

Immune Cells Become Active and Repair Brain While Sleep: Study

For the findings, researchers conducted the study on mice

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Study suggests that the enhanced remodeling of neural circuits and repair of lesions during Sleep may be mediated in part by the ability of microglia to dynamically interact with the Brain. Pixabay

Researchers have found that immune cells called microglia, which play an important role in reorganising the connections between nerve cells, fighting infections, and repairing damage, are also primarily active while we sleep.

Microglia serve as the brain’s first responders, patrolling the brain and spinal cord and springing into action to stamp out infections or gobble up debris from dead cell tissue.

“This research shows that the signals in our brain that modulate the sleep and awake state also act as a switch that turns the immune system off and on,” said study lead author Ania Majewska, Professor at University of Rochester in the US.

In previous studies, Majewska’s lab has shown how microglia interact with synapses, the juncture where the axons of one neuron connects and communicates with its neighbours.

The microglia help maintain the health and function of the synapses and prune connections between nerve cells when they are no longer necessary for brain function.

For the findings, researchers conducted the study on mice.

The current study points to the role of norepinephrine, a neurotransmitter that signals arousal and stress in the central nervous system.

This chemical is present in low levels in the brain while we sleep, but when production ramps up it arouses our nerve cells, causing us to wake up and become alert.

The study showed that norepinephrine also acts on a specific receptor, the beta2 adrenergic receptor, which is expressed at high levels in microglia.

When this chemical is present in the brain, the microglia slip into a sort of hibernation.

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Researchers have found that immune cells called microglia, which play an important role in reorganising the connections between nerve cells, fighting infections, and repairing damage, are also primarily active while we Sleep and affects Brain. Pixabay

The study, which employed an advanced imaging technology that allows researchers to observe activity in the living brain, showed that when mice were exposed to high levels of norepinephrine, the microglia became inactive and were unable to respond to local injuries and pulled back from their role in rewiring brain networks.

“This work suggests that the enhanced remodeling of neural circuits and repair of lesions during sleep may be mediated in part by the ability of microglia to dynamically interact with the brain,” said study first author Rianne Stowell.

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“Altogether, this research also shows that microglia are exquisitely sensitive to signals that modulate brain function and that microglial dynamics and functions are modulated by the behavioural state of the animal,” Stowell said.

The study was published in the journal Nature Neuroscience. (IANS)