Get subscribed to our newsletter
Get interesting updates to your email inbox.
Scientists have found a new clue that Parkinson’s disease may get its start not in the brain but in the gut – maybe in the appendix.
People who had their appendix removed early in life had a lower risk of getting the tremor-inducing brain disease decades later, researchers reported Wednesday.
Why? A peek at surgically removed appendix tissue shows this tiny organ, often considered useless, seems to be a storage depot for an abnormal protein – one that, if it somehow makes its way into the brain, becomes a hallmark of Parkinson’s.
The big surprise, according to studies published in the journal Science Translational Medicine: Lots of people may harbor clumps of that worrisome protein in their appendix – young and old, people with healthy brains and those with Parkinson’s.
But don’t look for a surgeon just yet.
“We’re not saying to go out and get an appendectomy,” stressed Viviane Labrie of Michigan’s Van Andel Research Institute, a neuroscientist and geneticist who led the research team.
After all, there are plenty of people who have no appendix yet still develop Parkinson’s. And plenty of others harbor the culprit protein but never get sick, according to her research.
The gut connection
Doctors and patients have long known there’s some connection between the gastrointestinal tract and Parkinson’s. Constipation and other GI troubles are very common years before patients experience tremors and movement difficulty that lead to a Parkinson’s diagnosis.
Wednesday’s research promises to re-energize work to find out why, and learn who’s really at risk.
“This is a great piece of the puzzle. It’s a fundamental clue,” said Dr. Allison Willis, a Parkinson’s specialist at the University of Pennsylvania who wasn’t involved in the new studies but says her patients regularly ask about the gut link.
Parkinson’s Foundation chief scientific officer James Beck, who also wasn’t involved, agreed that “there’s a lot of tantalizing potential connections.”
He noted that despite its reputation, the appendix appears to play a role in immunity that may influence gut inflammation. The type of bacteria that live in the gut also may affect Parkinson’s.
But if it really is common to harbor that Parkinson’s-linked protein, “what we don’t know is what starts it, what gets this whole ball rolling,” Beck said.
For years, scientists have hypothesized about what might cause the gut-Parkinson’s connection. One main theory: Maybe bad “alpha-synuclein” protein can travel from nerve fibers in the GI tract up the vagus nerve, which connects the body’s major organs to the brain. Abnormal alpha-synuclein is toxic to brain cells involved with movement.
There have been prior clues. People who decades ago had the vagus nerve cut as part of a now-abandoned therapy had a reduced risk of Parkinson’s. Some smaller studies have suggested appendectomies, too, might be protective – but the results were conflicting.
Labrie’s team set out to find stronger evidence.
First, the researchers analyzed Sweden’s huge national health database, examining medical records of nearly 1.7 million people tracked since 1964. The risk of developing Parkinson’s was 19 percent lower among those who had their appendix surgically removed decades earlier.
One puzzling caveat: People living in rural areas appeared to get the benefit. Labrie said it’s possible that the appendix plays a role in environmental risk factors for Parkinson’s, such as pesticide exposure.
Further analysis suggested people who developed Parkinson’s despite an early-in-life appendectomy tended to have symptoms appear a few years later than similarly aged patients.
A common protein
That kind of study doesn’t prove that removing the appendix is what reduces the risk, cautioned Dr. Andrew Feigin, executive director of the Parkinson’s institute at NYU Langone Health, who wasn’t involved in Wednesday’s research.
So next, Labrie’s team examined appendix tissue from 48 Parkinson’s-free people. In 46 of them, the appendix harbored the abnormal Parkinson’s-linked protein. So did some Parkinson’s patients. Whether the appendix was inflamed or not also didn’t matter.
That’s a crucial finding because it means merely harboring the protein in the gut isn’t enough to trigger Parkinson’s, Labrie said. There has to be another step that makes it dangerous only for certain people.
“The difference we think is how you manage this pathology,” she said – how the body handles the buildup.
Her team plans additional studies to try to tell.
The reservoir finding is compelling, Feigin said, but another key question is if the abnormal protein also collects in healthy people’s intestines.
And Penn’s Willis adds another caution: There are other unrelated risks for Parkinson’s disease, such as suffering a traumatic brain injury.
“This could be one of many avenues that lead to Parkinson’s disease, but it’s a very exciting one,” she said. (VOA)
What Is Bullying?
Bullying is a pattern of recurrent aggressive behavior in which one person (or a group of individuals) in a position of authority intentionally intimidate or abuse another individual to cause bodily or emotional harm to that other. Bullying may take place in either a physical or verbal manner. Bullied individuals, as well as those who bully others, may have long-term repercussions.
Bullying may occur anywhere, at any time, in person or online (cyberbullying), and can take many forms, including verbal, physical, and social. Bullies utilize their position of power — such as physical strength, knowledge of something embarrassing, or popularity — to exert control over or damage other people. Many people assume that bullying occurs solely during childhood; nevertheless, bullying does not necessarily stop after a person reaches the age of adulthood.
Bullies in adulthood can take the form of a threatening boss or colleague, a controlling partner, a relative, or any other type of person. Even in our personal and professional lives, we sometimes encounter adult bullies who can be harmful to our mental well-being.
Bullied individuals, as well as those who bully others, may have long-term repercussions. | Photo by Unsplash
How To Deal With An Adult Bully?
For obvious reasons, adult bullying can be a painful and challenging experience for anybody who finds themselves on the receiving end of such behavior. Knowing how to deal with the antics of a bully properly, on the other hand, may help you learn, develop, and feel better levels of confidence. When you find yourself in this scenario, one of the most crucial things to remember is that you must not exhibit the bully any signs of fear. This might be difficult, depending on the sort of bully you are dealing with, but bullies enjoy fear, encouraging them to continue with their terrible conduct.
Maintaining a sense of connection with other people while dealing with bullying is quite essential. Bullies usually see alone persons as easier targets since they have a smaller support network to challenge them.
Courage and a support network are significant advantages; but, reporting the bully is also an excellent line of action. Contrary to common opinion, just ignoring a bully does not always prompt them to cease their behavior. Adult bullies of all kinds often interpret being ignored as a sign of weakness, encouraging them to continue bullying. If someone is bullying you, don't be scared to speak out and report the individual.
No one can make you feel inferior without your consent ~Eleanor Roosevelt
Keywords: mental health, bullying, bully, bullied, courage, abuse, harass, support, cyberbully
Silver and gold have always been preferred when it comes to wearing jewellery. Right from the times of monarchy in India, wealth and riches have been associated with wearing gold and silver for the various properties they have. Copper is a metal that has always been worn by the poor. It is not a metal that carries a significant association with health or wealth, but wearing at least one article of copper is extremely beneficial for health.
Copper is a reddish-brown metal that cannot be worn on its own. It has to be worn in the form of an alloy to prevent a reaction. Copper oxidizes in air and forms a green layer on it when exposed, much like the Statue of Liberty. Usually, bangles, chains, or rings of copper always have brass and traces of silver in them which helps with stabilizing its reactivity.
Wearing copper with stones in it looks very aesthetic, but copper is not durable enough to hold the stones, which is why it is fashioned into elaborate designs and sold. Copper is very malleable, and over time, the bangle or ring will take the shape of the wearer's hand or finger.
A copper ring Image source: Wikimedia commons
Jewellery made out of copper can be an excellent health indicator. Copper helps metabolize bodily functions faster, and the wearer experiences relief from indigestion. It also soothes joint pain, headaches, and arthritis. Using copper utensils also aids those with deficiencies. Since copper is absorbed slowly into the body, there is no fear of causing any kind of imbalance.
Sometimes copper leaves a greenish tinge on the skin. This happens when it oxidizes with sweat. This stain can be washed away with soap and water, but the fact that it appears is noteworthy. It is an indicator of too much acidity in the body. Greenish skin appears when the wearer's diet includes too much meat or acidic foods.
Copper might not be a very attractive metal, but wearing it has a lot of benefits for the health. It regulates metabolism, assimilation, and indicates health. It is definitely a good idea to wear copper jewellery at least once in a while.
Keywords: Copper jewellery, Copper is a health indicator, Metabolism, Oxidation, Benefits of copper
By Md Waquar Haider
When popular smartphone brands like Xiaomi and realme entered the laptop market in India last year, they were expected to shake the existing giants, specifically under the Rs 50,000 category. However, chip shortage and supply crunch have somewhat dented their plans to make a significant mark to date. According to industry experts, the issue with smartphone makers entering the laptop category is two-fold. The first one is a massive supply crunch in the laptop component market and only big brands are able to get volume and supplies.
The other factor is that the traditional players are very strong in the consumer laptop market. Top 3 players control more than 70 per cent of the market and strong portfolio, distribution, and channel reach as well as brand marketing has helped them massively. "New brands can surely make a dent in the consumer laptop market but are challenged by supply issues right now. Watch out for them in 2022 as and when supply situation eases up," Navkendar Singh, Research Director, Client Devices & IPDS, IDC India told IANS.
Dominated by HP Inc, Lenovo and Dell, the traditional PC market (inclusive of desktops, notebooks, and workstations) in India continued to be robust as the shipments grew by 50.5 per cent year-over-year (YoY) in the second quarter (Q2), according to IDC. Notebook PCs continue to hold more than three-fourth share in the overall category and grew 49.9 per cent YoY in 2Q21, reporting a fourth consecutive quarter with over 2 million units. Desktops also indicated a recovery as shipments grew 52.3 per cent YoY after recording the lowest shipments of the decade in 2Q20.
According to Prabhu Ram, Head, Industry Intelligence Group, CMR, driven by the pandemic and the associated accelerated pivot to remote work, learn and unwind culture, PCs have been witnessing heightened demand. "Despite the current supply chain constraints, PCs are here to stay in the new never normal. In the run-up to the festive season, established PC market leaders will continue to leverage their brand salience and gain market share," Ram told IANS.
According to industry experts, the issue with smartphone makers entering the laptop category is two-fold. | Photo by Manuel on Unsplash
"On the other hand, there is a niche market for those new market entrants that are able to differentiate themselves from the competition in terms of features and value. "Alongside, they would need to back it with strong brand messaging to create awareness and recall amongst the target consumers," Ram added.
HP maintained its lead in the India PC market with a 33.6 per cent share as its shipments grew 54.2 per cent annually. Dell Technologies continued to hold the second position with a 22.1 per cent share and an impressive 86.1 per cent YoY growth in 2Q21. Lenovo maintained the third position with a share of 17.8 per cent in 2Q21.
Arvind Suraj, Research Fellow, Jawaharlal Nehru University (JNU), said that there is always a trust issue with new brands. "You won't buy a laptop in 6 or 7 months just like smartphones. In this case, we often go for existing players. Brands like Lenovo, HP, ASUS and Acer have already gained our trust," he said. (IANS/ MBI)
Keywords: Chip, shortage, laptop, market, India, Xiaomi, hp, dell, brands