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The team also identified eight ISGs that inhibited both SARS-CoV-1 and CoV-2 replication in the subcellular compartment responsible for protein packaging. Pixabay

A team of US scientists, led by an Indian-origin researcher, has identified a set of human genes that fight SARS-CoV-2 infection, the virus that causes Covid-19. According to Sumit K. Chanda, professor, and director of the Immunity and Pathogenesis Programme at Sanford Burnham Prebys Medical Discovery Institute, the scientists have gained new insights into how the virus exploits the human cells it invades.

“We are still searching for its Achille’s Heel so that we can develop optimal antivirals,” Chanda said in a paper published in the journal Molecular Cell. Knowing which genes help control viral infection can greatly assist researchers’ understanding of factors that affect disease severity and also suggest possible therapeutic options.


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The genes in question are related to interferons, the body’s frontline virus fighters. Soon after the start of the pandemic, clinicians found that a weak interferon response to SARS-CoV-2 infection resulted in some of the more severe cases of Covid-19.


As a next step, the researchers will look at the biology of SARS-CoV-2 variants that continue to evolve and threaten vaccine efficacy. Pixabay

This knowledge led Chanda and his collaborators to search for the human genes that are triggered by interferons, known as interferon-stimulated genes (ISGs), which act to limit SARS-CoV-2 infection.”We found that 65 ISGs controlled SARS-CoV-2 infection, including some that inhibited the virus’ ability to enter cells, some that suppressed manufacture of the RNA that is the virus’s lifeblood, and a cluster of genes that inhibited assembly of the virus,” Chanda explained.

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“What was also of great interest was the fact that some of the ISGs exhibited control across unrelated viruses, such as seasonal flu, West Nile and HIV, which leads to AIDS”.The team also identified eight ISGs that inhibited both SARS-CoV-1 and CoV-2 replication in the subcellular compartment responsible for protein packaging, suggesting this vulnerable site could be exploited to clear a viral infection.

“This is important information, but we still need to learn more about the biology of the virus and investigate if genetic variability within these ISGs correlates with Covid-19 severity,” said Laura Martin-Sancho, a senior postdoctoral associate in the Chanda lab. As a next step, the researchers will look at the biology of SARS-CoV-2 variants that continue to evolve and threaten vaccine efficacy. (IANS/JC)


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'Vikram Vedha' is a Hindi remake of the runaway Tamil hit of the same name which was released in 2017.

It's been over two years since Hrithik Roshan appeared on celluloid. Fans have been waiting to witness his next performance on the silver screen and it seems like their wishes will be soon granted. Earlier, Hrithik had made an announcement about getting back to shooting schedule for the upcoming film 'Vikram Vedha'. And now, it's learnt that the actor has recently wrapped the first ever action sequence from the film.

The news came out when a few stuntmen from the film's set shared pictures of the sequence wrap. The stunt sequences seem to be quite crazy as suggested by the stuntmen. Talking about the same, a stuntman posted on his instagram as he wrote, "Wrapped up the first action sequence of Vikram Vedha. A big 'Thank you' to @parvez.shaikhh sir for this opportunity. Wouldn't have been possible without you ?? @hrithikroshan."

Another stuntman posted, "First craziest action sequence have done (sic).!! Cheer's To @hrithikroshan @parvez.shaikhh @stuntindia1 and all the stunt boys.!!"

'Vikram Vedha' is a Hindi remake of the runaway Tamil hit of the same name which was released in 2017. While the original action thriller starred R. Madhavan and Vijay Sethupathi, the Hindi version will see Hrithik Roshan squaring off against Saif Ali Khan. (IANS/ MBI)


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