Wednesday July 18, 2018

Scientists identify 36 new genes implicated in cardiac disease

They found the transcription factor gene was directly connected to a whole network of proteins known to play a role in cardiac hypertrophy

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Gene (Representational image). IANS
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  • Scientists discovered 36 new genes
  • These are the genes implicated in cardiac diseases
  • These genes play a casual but important role in the diseases of heart

Researchers have identified 36 new genes that plays a causal role in cardiac hypertrophy — abnormal thickening of the heart muscle — which can lead to heart failure.

These genes can cause heart failure. Pixabay
These genes can cause heart failure. Pixabay

“This is an exciting direction for personalised medicine, and also for identifying genes and therapeutic targets for complex diseases that involve many genes,” said co-author of the study Alain Karma, professor at the Northeastern University. According to the Centres for Disease Control and Prevention, one in four deaths in the US each year are due to heart disease.

Also Read: Heart Surgery In Infants May Cause Deafness

“The framework described in the paper can also be used to predict whether individuals suffering from a particular disease will respond to a given drug treatment,” said lead author Marc Santolini, a postdoctoral research associate at Centre for Complex Network Research.

For the study, published in the journal npj Systems Biology, the researchers took an entirely different approach — using the Hybrid Mouse Diversity Panel, a collection of 100 genetically different strains of mice that can be used to analyse the genetic and environmental factors underlying complex traits.

The Science of Genetics behind Gotra system
The study was done on many kinds of genes and chemicals, Wikimedia Commons

Within each strain, the mice are inbred, making them all identical twins on a genetic level. Researchers took two mice from the same strain and gave one of them a stressor drug that induces heart failure. They then compared the stressed mouse’s gene expression with its non-stressed twin.

Since the mice have the same genome, they were able to pinpoint individual genes that changed expression as a direct result of the heart stressor.

Also Read: Heart Attack Symptoms In Women Often Misinterpreted

Among the identified 36 such genes, many of these genes were previously unknown to be implicated in heart failure, the researcher said. They mentioned that one of them is known as a transcription factor, meaning it controls the expression of many other genes.

They confirmed the gene’s role by using molecular biology techniques to silence it and observe the resulting changes of expression.

blood type
It is important to take care of one’s heart to avoid major health issues. Pixabay

They found the transcription factor gene was directly connected to a whole network of proteins known to play a role in cardiac hypertrophy. IANS

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Scientists Track ‘Ghost Particle’ to Source for First Time

The blazar that is considered the source of the neutrino was named TXS 0506+056 and is believed to be the first known source of a high-energy neutrino

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This artist's impression of the active galactic nucleus shows the supermassive black hole at the center of the accretion disk sending a narrow high-energy jet of matter into space, perpendicular to the disc in this image by Science Communication Lab in Kiel, Germany, released on July 12, 2018. In a study published in the journal Science, researchers have determined that a supermassive black hole like this one is the source of high-energy neutrinos detected on Earth. (VOA)

Scientists have announced a new finding about the source of a high-energy neutrino, a subatomic particle detected at an observatory at the Earth’s South Pole.

The study, published Thursday in the journal Science, details the work of more than 1,000 scientists who pooled their research on the tiny particles, which are able to pass through matter in a straight line — like a ghost.

The neutrino’s ability to travel without deviation from its course means its source can be accurately tracked, unlike other types of subatomic particles that can be dragged off course by a magnetic field like the Earth’s.

“[Neutrinos are] very clean, they have simple interactions, and that means every single neutrino interaction tells you something,” said Heidi Schellman, a particle physicist at Oregon State University.

Also Read: Scientists Develop Potential Approach to Treat Dementia, Stroke

The scientists used a large observatory known as IceCube, in use since 2010, to hunt for neutrinos and try to track the source. A group of neutrinos coming from the same location over the past couple of years was determined to have emanated from a blazar, or black hole that aims a jet of radiation at Earth. The black hole is estimated to have been in a distant galaxy that destructed four billion years ago.

The blazar that is considered the source of the neutrino was named TXS 0506+056 and is believed to be the first known source of a high-energy neutrino.

The discovery could be a breakthrough for multimessenger astronomy, where scientists look at the entire electromagnetic spectrum and pool their findings, using known relationships between types of electromagnetic particles to put together a larger picture.

“It is an entirely new means for us to learn about the cosmos,” Roopesh Ojha of NASA’s Goddard Space Flight Center told The Washington Post. (VOA)