Saturday January 19, 2019

Scientists identify 36 new genes implicated in cardiac disease

They found the transcription factor gene was directly connected to a whole network of proteins known to play a role in cardiac hypertrophy

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New gene for rare genetic hair loss discovered. IANS
  • Scientists discovered 36 new genes
  • These are the genes implicated in cardiac diseases
  • These genes play a casual but important role in the diseases of heart

Researchers have identified 36 new genes that plays a causal role in cardiac hypertrophy — abnormal thickening of the heart muscle — which can lead to heart failure.

These genes can cause heart failure. Pixabay
These genes can cause heart failure. Pixabay

“This is an exciting direction for personalised medicine, and also for identifying genes and therapeutic targets for complex diseases that involve many genes,” said co-author of the study Alain Karma, professor at the Northeastern University. According to the Centres for Disease Control and Prevention, one in four deaths in the US each year are due to heart disease.

Also Read: Heart Surgery In Infants May Cause Deafness

“The framework described in the paper can also be used to predict whether individuals suffering from a particular disease will respond to a given drug treatment,” said lead author Marc Santolini, a postdoctoral research associate at Centre for Complex Network Research.

For the study, published in the journal npj Systems Biology, the researchers took an entirely different approach — using the Hybrid Mouse Diversity Panel, a collection of 100 genetically different strains of mice that can be used to analyse the genetic and environmental factors underlying complex traits.

The Science of Genetics behind Gotra system
The study was done on many kinds of genes and chemicals, Wikimedia Commons

Within each strain, the mice are inbred, making them all identical twins on a genetic level. Researchers took two mice from the same strain and gave one of them a stressor drug that induces heart failure. They then compared the stressed mouse’s gene expression with its non-stressed twin.

Since the mice have the same genome, they were able to pinpoint individual genes that changed expression as a direct result of the heart stressor.

Also Read: Heart Attack Symptoms In Women Often Misinterpreted

Among the identified 36 such genes, many of these genes were previously unknown to be implicated in heart failure, the researcher said. They mentioned that one of them is known as a transcription factor, meaning it controls the expression of many other genes.

They confirmed the gene’s role by using molecular biology techniques to silence it and observe the resulting changes of expression.

blood type
It is important to take care of one’s heart to avoid major health issues. Pixabay

They found the transcription factor gene was directly connected to a whole network of proteins known to play a role in cardiac hypertrophy. IANS

Next Story

Genes of Your Uncle or Aunt May Decide Your Longevity, Says Study

The study has led us to be far stricter in selecting the people in whom you have to look for those genes, the researchers said

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genes
Your uncle's genes may decide your longevity: Study. Pixabay

The key to longevity can probably be found in the genes of your long-living uncles and aunts and not just parents, finds a study.

Researchers, from Netherlands’ Leiden University and US’ University of Utah, showed that an individual’s chances of dying is reduced, even if the parents themselves did not live to be extremely old, but aunts and uncles are among the top survivors in the family.

Top survivors refers to people in the top 10 per cent age-wise of a group of people born in a family within a given time period.

“We observed the more long-lived relatives you have, the lower your hazard of dying at any point in life,” said lead author Niels van den Berg, doctoral student at Leiden University in the Netherlands.

“Longevity is heritable, but that primarily applies to persons from families where multiple members are among the top 10 per cent survivors of their birth cohort. The key to a long life can probably be found in the genes of these families,” said the paper published in the journal Nature Communications.

Genes. Pixabay

For the study, the team analysed the genealogies of nearly 314,819 people from over 20,360 families.

The search for genes associated with human longevity has been ongoing for a long time but those genes turned out to be much more difficult to discover than genes for diseases.

Also Read- “I Never Worked For Russia”, Says US President Donald Trump

The study has led us to be far stricter in selecting the people in whom you have to look for those genes, the researchers said.

According to Ken Smith, Professor at Utah, the findings underscore the importance of constructing high-quality family trees that “allow us to observe complete life-spans of individuals over generations and in diverse locations. (IANS)