Sunday November 17, 2019

Scientists identify 36 new genes implicated in cardiac disease

They found the transcription factor gene was directly connected to a whole network of proteins known to play a role in cardiac hypertrophy

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gene
New gene for rare genetic hair loss discovered. IANS
  • Scientists discovered 36 new genes
  • These are the genes implicated in cardiac diseases
  • These genes play a casual but important role in the diseases of heart

Researchers have identified 36 new genes that plays a causal role in cardiac hypertrophy — abnormal thickening of the heart muscle — which can lead to heart failure.

These genes can cause heart failure. Pixabay
These genes can cause heart failure. Pixabay

“This is an exciting direction for personalised medicine, and also for identifying genes and therapeutic targets for complex diseases that involve many genes,” said co-author of the study Alain Karma, professor at the Northeastern University. According to the Centres for Disease Control and Prevention, one in four deaths in the US each year are due to heart disease.

Also Read: Heart Surgery In Infants May Cause Deafness

“The framework described in the paper can also be used to predict whether individuals suffering from a particular disease will respond to a given drug treatment,” said lead author Marc Santolini, a postdoctoral research associate at Centre for Complex Network Research.

For the study, published in the journal npj Systems Biology, the researchers took an entirely different approach — using the Hybrid Mouse Diversity Panel, a collection of 100 genetically different strains of mice that can be used to analyse the genetic and environmental factors underlying complex traits.

The Science of Genetics behind Gotra system
The study was done on many kinds of genes and chemicals, Wikimedia Commons

Within each strain, the mice are inbred, making them all identical twins on a genetic level. Researchers took two mice from the same strain and gave one of them a stressor drug that induces heart failure. They then compared the stressed mouse’s gene expression with its non-stressed twin.

Since the mice have the same genome, they were able to pinpoint individual genes that changed expression as a direct result of the heart stressor.

Also Read: Heart Attack Symptoms In Women Often Misinterpreted

Among the identified 36 such genes, many of these genes were previously unknown to be implicated in heart failure, the researcher said. They mentioned that one of them is known as a transcription factor, meaning it controls the expression of many other genes.

They confirmed the gene’s role by using molecular biology techniques to silence it and observe the resulting changes of expression.

blood type
It is important to take care of one’s heart to avoid major health issues. Pixabay

They found the transcription factor gene was directly connected to a whole network of proteins known to play a role in cardiac hypertrophy. IANS

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Here’s Why Complimentary Cancer Therapies Can Cause More Harm

Doctors need to be more proactive about asking their patients what else they are taking when they are being treated for cancer

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Cancer
It is particularly important that patients always check with their doctors first before trying complementary therapies for Cancer that has spread to the skin. Pixabay

A medical expert has said that Cancer patients should tell doctors treating them about the herbal products they may be taking since some ingredients could affect their treatment.

Maria Joao Cardoso, the head breast surgeon at the Champalimaud Cancer Centre in Lisbon, Portugal, said that there was no evidence that herbal therapies or creams worked.

If in doubt, it is best not to take anything, she added.

Garlic, ginger and ginkgo pills, for example, can delay the healing of skin wounds when breast cancer spreads, she said.

“Doctors need to be more proactive about asking their patients what else they are taking when they are being treated for cancer,” Cardoso told the BBC.

She said that it is particularly important that patients always check with their doctors first before trying complementary therapies for cancer that has spread to the skin. This happens in one in five cases of breast cancer, and less in other cancers.

The danger is that many products can interfere with the hormone therapy or chemotherapy treatments, and certain ones prolong the blood clotting process, which can lead to wounds taking longer time to heal and more scarring.

She said that herbal products like green chiretta, feverfew, garlic, ginkgo, ginseng, hawthorn, horse chestnut and turmeric slow down clotting.

Cancer
A medical expert has said that Cancer patients should tell doctors treating them about the herbal products they may be taking since some ingredients could affect their treatment. Pixabay

Cardoso said that it is not surprising that patients and their carers go searching for complementary or alternative treatments that might make a difference.

But she said people should know that “they could end up doing more harm than good”.

ALSO READ: Fitbit to Unveil Latest Update for its Smartwatch

“The highest goal in medicine is important to remember: Do no harm,” she said.

As per the website of Cancer Research UK, some complementary therapies might stop conventional treatments working as well as they should. (IANS)