Wednesday, March 3, 2021
Home Life Style Health & Fitness Scientists develop 3D model of cells to help Parkinson's patients

Scientists develop 3D model of cells to help Parkinson’s patients

London: In a major step towards development of personalised drugs for Parkinson’s patients, researchers have managed to grow three dimensional models of cells that are lost with the progress of the disease.

The progressive loss of neurons in the brain of Parkinson’s patients is slow yet inexorable. So far, there are no drugs that can halt this insidious process.

“This is an important step towards personalised drug development,” said study leader Ronan Fleming from Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg.

indianexpress.com
indianexpress.com

Parkinson’s disease is characterised, in particular, by death of dopamine-producing neurons in the Substantia-nigra of the midbrain.

It is already possible to grow these dopaminergic neurons in cell cultures.

“But most such cell cultures are two-dimensional, with the cells growing along the base of a petri dish, for example,” Fleming said.  He added, “Instead, we have the neurons grow in a gel that yields a far better model of their natural, three-dimensional environment.”

The scientists are confident that this system could greatly facilitate the continuing search for therapeutic agents in future as it models the natural conditions in the brain more realistically than other systems available so far.

It is also significantly cheaper to employ in the laboratory, the researchers said.

As a next step, Fleming’s team and their international collaborators want to study cells from patients and to test potential active pharmaceutical ingredients.

Promising substances will then be tested in mice, the researchers said.

The results were recently published in the journal Lab on a Chip.

(IANS)

STAY CONNECTED

19,120FansLike
362FollowersFollow
1,773FollowersFollow

Most Popular

About 5K Indians Stalking Their Partners Via Mobile Spyware

As some people try to digitally control the lives of their intimate partners, nearly 4,627 mobile users in India have been found to be...

Alcohol And Tobacco Sales Rose During The Early Months Of Covid-19

In a finding that shows that the pandemic may also have harmful indirect consequences, a new study has found that alcohol and tobacco sales...

Google Chrome Browser To Increase Browser Safety

Google's Chrome browser will soon try to use HTTPS as default when users forget to type the HTTP or HTTPS prefix. The move is...

India Aims To Operationalise 23 Waterways by 2030: PM Modi

Inviting the world to come to India and be a part of the country's growth trajectory, Prime Minister Narendra Modi on Tuesday announced that...

85% Women in India Have Been Disproportionately Impacted Amid COVID: LinkedIn Report

Women have been disproportionately impacted amid the Covid-19 pandemic in India and 85 per cent of those surveyed have missed out on a raise...

Research: The Pandemic Has Affected Tourists’ Attitudes And Behaviors

The pandemic has affected tourists' attitudes and behaviors in unforeseen ways, often subconsciously, said a new study. The study, published in the journal Annals...

An Innovative Portable Machine Efficiently Collecting Plastic Bags

A team of students has developed an innovative portable and low-cost machine that efficiently collects discarded plastic bags. According to recent FICCI estimates, India's...

Extended Screen Time Linked To Binge Eating Disorder

Children who spend a lot of time on social media platforms or watching TV at ages 9-10 are more likely to develop binge-eating disorder...

Recent Comments