New York, April 11, 2017: Scientists have found a way to create an HIV-resistant cell population which can quickly replace diseased cells, thereby potentially curing the disease in an infected person.
“This protection would be long-term,” said Jia Xie, senior staff scientist at The Scripps Research Institute (TSRI) in the US and first author of the study published in the journal Proceedings of the National Academy of Sciences.
The researchers found a way to tether HIV-fighting antibodies to immune cells, thereby creating a cell population resistant to the virus.
Their experiments under lab conditions showed that these resistant cells can replace diseased cells.
The new technique offers a significant advantage over therapies where antibodies float freely in the bloodstream at a relatively low concentration, the researchers said.
Instead, antibodies in the new study hang on to a cell’s surface, blocking HIV from accessing a crucial cell receptor and spreading infection.
The researchers said they plan to collaborate with investigators at City of Hope — an independent research and treatment centre for cancer, diabetes and other life-threatening diseases in the US — to evaluate this new therapy in efficacy and safety tests, as required by federal regulations, prior to testing in patients. (IANS)
After years of nursing a sometimes dusty cylinder of metal in a vault outside Paris as the global reference for modern mass, scientists are updating the definition of the kilogram.
Just as the redefinition of the second in 1967 helped to ease communication across the world via technologies like GPS and the internet, experts say the change in the kilogram will be better for technology, retail and health — though it probably won’t change the price of fish much.
The kilogram has been defined since 1889 by a shiny piece of platinum-iridium held in Paris. All modern mass measurements are traceable back to it — from micrograms of pharmaceutical medicines to kilos of apples and pears and tons of steel or cement.
The problem is, the “international prototype kilogram” doesn’t always weigh the same. Even inside its three glass bell jars, it gets dusty and dirty, and is affected by the atmosphere. Sometimes, it really needs a wash.
“We live in a modern world. There are pollutants in the atmosphere that can stick to the mass,” said Ian Robinson, a specialist in the engineering, materials and electrical science department at Britain’s National Physical Laboratory.
“So when you just get it out of the vault, it’s slightly dirty. But the whole process of cleaning or handling or using the mass can change its mass. So it’s not the best way, perhaps, of defining mass.”
What’s needed is something more constant.
So, at the end of a week-long meeting in the Palace of Versailles, Paris, the world’s leading measurement aficionados at the International Bureau of Weights and Measures will vote Friday to make an “electronic kilogram” the new baseline measure of mass.
Just as the meter — once the length of a bar of platinum-iridium, also kept in Paris — is now defined by the constant speed of light in a vacuum, so a kilogram will be defined by a tiny but immutable fundamental value called the “Planck constant.”
The new definition involves an apparatus called the Kibble balance, which makes use of the constant to measure the mass of an object using a precisely measured electromagnetic force.
“In the present system, you have to relate small masses to large masses by subdivision. That’s very difficult — and the uncertainties build up very, very quickly,” Robinson said.
“One of the things this [new] technique allows us to do is to actually measure mass directly at whatever scale we like, and that’s a big step forward.”