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Scientists Take Step Toward Creating Artificial Embryos

Experts said the results suggested human embryos could be created in a similar way in future — a step that would allow scientists to use artificial embryos rather than real ones to research the very earliest stages of human development

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FILE - An embryologist demonstrates fertilization techniques at a clinic in New York, Oct. 3, 2013. In work published Monday, scientists moved closer to creating artificial embryos. (VOA)
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An international team of scientists has moved closer to creating artificial embryos after using mouse stem cells to make structures capable of taking a crucial step in the development of life.

Experts said the results suggested human embryos could be created in a similar way in future — a step that would allow scientists to use artificial embryos rather than real ones to research the very earliest stages of human development.

The team, led by Magdalena Zernicka-Goetz, a professor at Britain’s Cambridge University, had previously created a simpler structure resembling a mouse embryo in a lab dish. That work involved two types of stem cells and a three-dimensional scaffold on which they could grow.

But in new work published Monday in the journal Nature Cell Biology, the scientists developed the structures further — using three types of stem cells — enabling a process called gastrulation, an essential step in which embryonic cells begin self-organizing into a correct structure for an embryo to form.

“Our artificial embryos underwent the most important event in life in the culture dish,” Zernicka-Goetz said in a statement about the work. “They are now extremely close to real embryos.”

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The early stages of embryo development are when a large proportion of pregnancies are lost and yet it is a stage that scientists know very little about.

She said the team should now be better able to understand how the three stem cell types interact to enable embryo development. And by experimentally altering biological pathways in one cell type, they should be able to see how this affects the behavior of the other cell types.

“The early stages of embryo development are when a large proportion of pregnancies are lost and yet it is a stage that we know very little about,” said Zernicka-Goetz.

“Now we have a way of simulating embryonic development in the culture dish, so it should be possible to understand exactly what is going on during this remarkable period in an embryo’s life, and why sometimes this process fails.”

Also Read: Scientists in US Successfully Edit Genes of Human Embryos in the First Attempt

Christophe Galichet, a senior research scientist at Britain’s Francis Crick Institute who was not directly involved in this work, agreed that the results held promise.

“While [this study] did not use human stem cells, it is not too far-fetched to think the technique could one day be applied to studying early human embryos,” he said in an emailed comment. “These self-assembled human embryos would be an invaluable tool to understand early human development.” (VOA)

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Scientists Track ‘Ghost Particle’ to Source for First Time

The blazar that is considered the source of the neutrino was named TXS 0506+056 and is believed to be the first known source of a high-energy neutrino

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This artist's impression of the active galactic nucleus shows the supermassive black hole at the center of the accretion disk sending a narrow high-energy jet of matter into space, perpendicular to the disc in this image by Science Communication Lab in Kiel, Germany, released on July 12, 2018. In a study published in the journal Science, researchers have determined that a supermassive black hole like this one is the source of high-energy neutrinos detected on Earth. (VOA)

Scientists have announced a new finding about the source of a high-energy neutrino, a subatomic particle detected at an observatory at the Earth’s South Pole.

The study, published Thursday in the journal Science, details the work of more than 1,000 scientists who pooled their research on the tiny particles, which are able to pass through matter in a straight line — like a ghost.

The neutrino’s ability to travel without deviation from its course means its source can be accurately tracked, unlike other types of subatomic particles that can be dragged off course by a magnetic field like the Earth’s.

“[Neutrinos are] very clean, they have simple interactions, and that means every single neutrino interaction tells you something,” said Heidi Schellman, a particle physicist at Oregon State University.

Also Read: Scientists Develop Potential Approach to Treat Dementia, Stroke

The scientists used a large observatory known as IceCube, in use since 2010, to hunt for neutrinos and try to track the source. A group of neutrinos coming from the same location over the past couple of years was determined to have emanated from a blazar, or black hole that aims a jet of radiation at Earth. The black hole is estimated to have been in a distant galaxy that destructed four billion years ago.

The blazar that is considered the source of the neutrino was named TXS 0506+056 and is believed to be the first known source of a high-energy neutrino.

The discovery could be a breakthrough for multimessenger astronomy, where scientists look at the entire electromagnetic spectrum and pool their findings, using known relationships between types of electromagnetic particles to put together a larger picture.

“It is an entirely new means for us to learn about the cosmos,” Roopesh Ojha of NASA’s Goddard Space Flight Center told The Washington Post. (VOA)

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