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Severity of Diarrhoea is Affected by the Blood Types

Enterotoxigenic E. coli are responsible for millions of cases of diarrhoea and hundreds of thousands of deaths every year, mainly of young children.

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More than eight of 10 (81 per cent) blood group A people developed diarrhoea that required treatment, as compared with about half of people with blood group B or O.
Advancements in the medical field. Pixabay.

A bacteria associated with travellers’ diarrhoea and children in underdeveloped areas of the world causes more severe disease in people with blood type A but not blood type O or B, finds a study.

Enterotoxigenic E. coli are responsible for millions of cases of diarrhoea and hundreds of thousands of deaths every year, mainly of young children.
Types of Blood. Pixabay.

Enterotoxigenic E. coli are responsible for millions of cases of diarrhoea and hundreds of thousands of deaths every year, mainly of young children.

The bacteria release a protein that latches onto intestinal cells in people with blood type A, but not blood type O or B.

A vaccine targeting that protein could potentially protect people with type A blood against the deadliest effects of enterotoxigenic E. coli (Escherichia coli) infection.

“We think this protein is responsible for this blood-group difference in disease severity,” said James Fleckenstein, Associate Professor at the Washington University in St. Louis.

“A vaccine targeting this protein would potentially protect the individuals at highest risk for severe disease.”

For the study, published in The Journal of Clinical Investigation, the team gave healthy volunteers a dose of an E. coli strain originally isolated from a person in Bangladesh with severe, cholera-like diarrhoea.

They observed the volunteers for five days and obtained data and blood samples from over 100 people and found that people with blood type A got sick sooner and more seriously than those of other blood types.

More than eight of 10 (81 per cent) blood group A people developed diarrhoea that required treatment, as compared with about half of people with blood group B or O.

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The researchers also found that the bacteria produce a specific protein that sticks to A-type sugars – but not B or O-type sugars – on intestinal cells.

Since the protein also sticks to E. coli, it effectively fastens the bacteria to the intestinal wall, making it easy for them to deliver diarrhoea-causing toxins to intestinal cells.

The effect of blood group in people infected with this strain of E. coli was striking and significant, but it doesn’t mean people should change their behaviour based on blood type, the researchers said. IANS.

Next Story

Measles Spread in Google’s Headquarters, Employees Discussing Ways To Protect Themselves

A select group of employees learned about the incident more than a week later, on April 13, when a company doctor emailed them about the infected the employee, the report said. 

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Later, however, the staff doctor sent a message to multiple internal groups at Google, reassuring a that they were safe while acknowledging that his communication had been "slow". Pixabay

Executives at Google’s Silicon Valley headquarters are discussing ways to protect themselves and their families from measles after one of them was found working at the office despite being infected by the highly contagious virus.

On Google’s internal forums, employees expressed shock because they were not told sooner about their sick colleague who had been spending time in its Mountain View office building — including a campus restaurant, BuzzFeed News reported on Thursday.

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Public health experts blame the uptick partially on the spread of anti-vaccine falsehoods on social media platforms, including Google’s YouTube, which, under public pressure, recently removed ads from known anti-vaccine video channels, the report said. Pixabay

The employee was present in the office on April 4.

A select group of employees learned about the incident more than a week later, on April 13, when a company doctor emailed them about the infected the employee, the report said.

Later, however, the staff doctor sent a message to multiple internal groups at Google, reassuring a that they were safe while acknowledging that his communication had been “slow”.

The reported case is part of a historic resurgence of measles in the US.

google
On Google’s internal forums, employees expressed shock because they were not told sooner about their sick colleague who had been spending time in its Mountain View office building — including a campus restaurant, BuzzFeed News reported on Thursday. Pixabay

Also Read: Apple’s Recycling Robot Is Capable of Disassembling 200 iPhones Per Hour
At least 555 people have been infected this year by the virus, which was declared eliminated in 2000, according to the Centres for Disease Control and Prevention (CDC).

Public health experts blame the uptick partially on the spread of anti-vaccine falsehoods on social media platforms, including Google’s YouTube, which, under public pressure, recently removed ads from known anti-vaccine video channels, the report said.  (IANS)