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Severity of Diarrhoea is Affected by the Blood Types

Enterotoxigenic E. coli are responsible for millions of cases of diarrhoea and hundreds of thousands of deaths every year, mainly of young children.

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More than eight of 10 (81 per cent) blood group A people developed diarrhoea that required treatment, as compared with about half of people with blood group B or O.
Advancements in the medical field. Pixabay.

A bacteria associated with travellers’ diarrhoea and children in underdeveloped areas of the world causes more severe disease in people with blood type A but not blood type O or B, finds a study.

Enterotoxigenic E. coli are responsible for millions of cases of diarrhoea and hundreds of thousands of deaths every year, mainly of young children.
Types of Blood. Pixabay.

Enterotoxigenic E. coli are responsible for millions of cases of diarrhoea and hundreds of thousands of deaths every year, mainly of young children.

The bacteria release a protein that latches onto intestinal cells in people with blood type A, but not blood type O or B.

A vaccine targeting that protein could potentially protect people with type A blood against the deadliest effects of enterotoxigenic E. coli (Escherichia coli) infection.

“We think this protein is responsible for this blood-group difference in disease severity,” said James Fleckenstein, Associate Professor at the Washington University in St. Louis.

“A vaccine targeting this protein would potentially protect the individuals at highest risk for severe disease.”

For the study, published in The Journal of Clinical Investigation, the team gave healthy volunteers a dose of an E. coli strain originally isolated from a person in Bangladesh with severe, cholera-like diarrhoea.

They observed the volunteers for five days and obtained data and blood samples from over 100 people and found that people with blood type A got sick sooner and more seriously than those of other blood types.

More than eight of 10 (81 per cent) blood group A people developed diarrhoea that required treatment, as compared with about half of people with blood group B or O.

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The researchers also found that the bacteria produce a specific protein that sticks to A-type sugars – but not B or O-type sugars – on intestinal cells.

Since the protein also sticks to E. coli, it effectively fastens the bacteria to the intestinal wall, making it easy for them to deliver diarrhoea-causing toxins to intestinal cells.

The effect of blood group in people infected with this strain of E. coli was striking and significant, but it doesn’t mean people should change their behaviour based on blood type, the researchers said. IANS.

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Scientists Develop A New Technique to Measure Blood Clot

The technique, led by the University of Exeter researchers, investigates a part of the blood clotting process which focuses on the ways in which platelets from blood samples clump together.

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The researchers discovered that the enzyme NADPH Oxidase is critically important for the generation of free radicals, the stimulation of blood clotting and the promotion of blood vessel damage in patients. Pixabay

Scientists have developed a new technique that allows them to measure blood clotting as well as the formation of free radicals, that leads to the build-up of blood clots, which in turn cause heart disease, stroke and dementia.

The technique, led by the University of Exeter researchers, investigates a part of the blood clotting process which focuses on the ways in which platelets from blood samples clump together.

“This method may be useful for future studies looking into new anti-platelet treatments for diseases such as diabetes, where clotting is disturbed and increases the risk of heart attack or stroke,” according to the study detailed in the Haematologica journal.

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The technique, led by the University of Exeter researchers, investigates a part of the blood clotting process which focuses on the ways in which platelets from blood samples clump together. Pixabay

The researchers discovered that the enzyme NADPH Oxidase is critically important for the generation of free radicals, the stimulation of blood clotting and the promotion of blood vessel damage in patients.

They successfully used the technique in mice and human cells. Their aim is to better understand how blood cells function, which will help to develop new drugs against blood clotting diseases or to test the risk of clotting diseases in patients.

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“We’re really excited to discover this new technique and its potential to understand how blood vessel diseases develop. For the first time, we can now simultaneously measure blood clotting and the formation of free radicals,” said lead author Giordano Pula, from the Exeter Medical School.

“We know they play a key role in blood vessel damage caused by ageing, diabetes, obesity and chronic inflammation. We’re currently using this technique in our efforts to develop a new treatment to protect the blood vessels in diseases such as heart diseases, stroke, obesity, and vascular dementia,” Pula added. (IANS)