Saturday July 20, 2019

Simple Blood Test can Diagnose Fibromyalgia for the First Time

There is no cure for fibromyalgia, but medication, exercise and stress reduction measures can help control the symptoms

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Fibromyalgia
Constant pain is a symptom of fibromyalgia. Barb Hartong suffered from this disorder for a long time before she finally got the right diagnosis. VOA

Millions of people live with the constant pain of fibromyalgia. It’s a disorder that’s often misdiagnosed. And while lab tests can help identify a lot of diseases, until recently there was no test for fibromyalgia. Now, a simple blood test could finally give these patients scientific proof of their condition.

Constant pain is a symptom of fibromyalgia. Barb Hartong suffered from this disorder for a long time before she finally got the right diagnosis. “It was almost a relief because I finally knew what was wrong with me,” Hartong said.

Fibromyalgia is a disorder with symptoms of widespread muscle and joint pain, accompanied by fatigue and problems with sleep, memory and mood. Researchers believe that with fibromyalgia, the brain amplifies the pain signals it gets. About 75 percent of those who suffer from fibromyalgia are undiagnosed. Some people live with pain for years. Many patients receive treatment that’s ineffective or even harmful.

Researchers at the Ohio State University Wexner Medical Center formed a multi-disciplinary team to see if they could develop a laboratory test to diagnose this disorder and make it easier for patients to get some relief. Dr. Kevin Hackshaw led the study.

“Many of the patients with chronic opiate use turn out to have underlying fibromyalgia. So in fact, if that was recognized then we could realize that we can stem the tide of treating them inappropriately with opiates,” Hackshaw said.

The result was a simple blood test that could diagnose fibromyalgia with nearly 100 percent accuracy. Hackshaw worked with researchers at the Ohio State food science and technology department. They found that same technology used to quickly analyze different components in food, like protein and fat, can also analyze chemicals in the blood. Dr. Luis Rodriguez-Saona was the study’s co-author.

“We use infrared in many companies to determine protein, fat, moisture, starch levels, fiber in seconds,” Rodriguez-Saona said. Rodriguez-Saona says each person’s blood is unique, like a fingerprint, and this test can show the intricate details of that fingerprint. It can distinguish fibromyalgia from other chronic pain conditions with nearly 100 percent accuracy. The test uses a color-coded computer program. “The brown colored squares, these belong to the fibromyalgia, the red ones are rheumatoid arthritis and the green ones are lupus,” Rodriguez-Saona said.

ALSO READ: Experts Warn Human Genome Editing is Too Risky

Hackshaw says when people learn the results they feel relieved just like Barb Hartong did. “A test like this provides confirmation and validation of the symptoms they’ve been suffering for years,” Hackshaw said.

There is no cure for fibromyalgia, but medication, exercise and stress reduction measures can help control the symptoms. Hartong takes medication and sticks to a daily routine. “It’s not just giving me a pill, it’s how do I live? For me, it’s exercise,” Hartong said.

The researchers now want to use the test on a larger group of patients to see if they get the same results. If the test is approved, doctors will be able to diagnose fibromyalgia instantly and save patients years of suffering. (VOA)

Next Story

Scientists Closing in on Blood Test to Screen People for Possible Signs of Alzheimer’s Disease

A blood test — rather than subjective estimates of thinking skills — could get the right people into studies sooner

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FILE - Dr. Jori Fleisher, neurologist, examines Thomas Doyle, 66, at the Rush University Medical Center in Chicago, July 9, 2019. VOA

Scientists are closing in on a long-sought goal — a blood test to screen people for possible signs of Alzheimer’s disease and other forms of dementia. On Monday at the Alzheimer’s Association International Conference, half a dozen research groups gave new results on various experimental tests, including one that seems 88% accurate at indicating Alzheimer’s risk.

Doctors are hoping for something to use during routine exams, where most dementia symptoms are evaluated, to gauge who needs more extensive testing. Current tools such as brain scans and spinal fluid tests are too expensive or impractical for regular check-ups.

“We need something quicker and dirtier. It doesn’t have to be perfect” to be useful for screening, said Maria Carrillo, the Alzheimer’s Association’s chief science officer.

Dr. Richard Hodes, director of the National Institute on Aging, called the new results “very promising” and said blood tests soon will be used to choose and monitor people for federally funded studies, though it will take a little longer to establish their value in routine medical care.

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“Even though no medical treatment is without risk, getting treatment for high blood pressure could be important to maintain brain health in patients with Alzheimer’s disease,” Claassen said. Pixabay 

“In the past year we’ve seen a dramatic acceleration in progress” on these tests, he said. “This has happened at a pace that is far faster than any of us would have expected.”

It can’t come too soon for patients like Tom Doyle, a 66-year-old former university professor from Chicago who has had two spinal fluid tests since developing memory problems four years ago. First he was told he didn’t have Alzheimer’s, then that he did. He ultimately was diagnosed with different problems — Lewy body dementia with Parkinson’s.

“They probably could have diagnosed me years ago accurately if they had had a blood test,” said Doyle, who represents patients on the Alzheimer’s Association’s board.

88% accuracy overall

About 50 million people worldwide have dementia, and Alzheimer’s is the most common form. There is no cure; current medicines just temporarily ease symptoms. Dozens of hoped-for treatments have failed. Doctors think studies may have enrolled people after too much brain damage had occurred and included too many people with problems other than Alzheimer’s.

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Poor sleep can predict Alzheimer’s Risk in elderly. Pixabay

A blood test — rather than subjective estimates of thinking skills — could get the right people into studies sooner. One of the experimental blood tests measures abnormal versions of the protein that forms the plaques in the brain that are the hallmark of Alzheimer’s. Last year, Japanese researchers published a study of it and on Monday they gave results from validation testing on 201 people with Alzheimer’s, other types of dementia, mild impairment or no symptoms.

The blood test results closely matched those from the top tests used now — three types of brain scans and a mental assessment exam, said Dr. Akinori Nakamura of the National Center for Geriatrics and Gerontology in Obu, Japan. The test correctly identified 92% of people who had Alzheimer’s and correctly ruled out 85% who did not have it, for an overall accuracy of 88%. Shimadzu Corp. has rights to the test and is working to commercialize it, Nakamura said.

Ruling out disorders

Another experimental test looks at neurofilament light, a protein that’s a marker of nerve damage. Abdul Hye of King’s College London gave results of a study comparing blood levels of it in 2,300 people with various neurological conditions — Alzheimer’s, other dementias, Parkinson’s, depression, multiple sclerosis, Lou Gehrig’s disease — plus healthy folks for comparison.

Levels were significantly higher in eight conditions, and only 2% of healthy folks were above a threshold they set for raising concern. The test doesn’t reveal which disorder someone has, but it may help rule one out when symptoms may be psychological or due to other problems.

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Like the Japanese test, it measures the abnormal Alzheimer protein, and the new results will show how well the test reflects what brain scans show on nearly 500 people. Pixabay

Later at the conference, Dr. Randall Bateman of Washington University School of Medicine in St. Louis will give new results on a blood test he helped develop that the university has patented and licensed to C2N Diagnostics, a company he co-founded. Like the Japanese test, it measures the abnormal Alzheimer protein, and the new results will show how well the test reflects what brain scans show on nearly 500 people.

“Everyone’s finding the same thing … the results are remarkably similar across countries, across techniques,” said Bateman, whose work is supported by the U.S. government and the Alzheimer’s Association. He estimates a screening test could be as close as three years away.

ALSO READ: Healthy Lifestyle Can Cut Risk of Developing Alzheimer Even if You Have High Genetic Risk: Study

What good will that do without a cure?

An Associated Press-NORC Center for Public Affairs Research poll last year found that most Americans would want to know if they carried a gene tied to a disease even if it was incurable. “What people want most of all is a diagnosis” if they’re having symptoms, said Jonathan Schott of University College London. “What we don’t like is not knowing what’s going on.” (VOA)