Never miss a story

Get subscribed to our newsletter


×
A nanoparticle vaccine that elicits a virus-neutralizing antibody response. Pixabay

Researchers have developed a nanoparticle vaccine that elicits a virus-neutralizing antibody response after a single dose. The team, including Peter Kim from Stanford University in the US, said that the primary target for Covid-19 vaccines is the spike protein, which is necessary for SARS-CoV-2’s entry into cells.

Both of the vaccines are mRNA vaccines that cause human cells to temporarily produce the spike protein, triggering an immune response and antibody production. For the study, published in the ACS Central Science journal, the team wanted to try a different approach: a vaccine consisting of multiple copies of the spike protein displayed on ferritin nanoparticles, in a mice-based experiment.


Follow NewsGram on Twitter to stay updated about the World news.

Ferritin is an iron storage protein found in many organisms that self-assembles into a larger nanoparticle. Other proteins, such as viral antigens, can be fused to ferritin so that each nanoparticle displays several copies of the protein, which might cause a stronger immune response than a single copy.


Both of the vaccines are mRNA vaccines. Pixabay

The researchers spliced spike protein and ferritin DNA together and then expressed the hybrid protein in cultured mammalian cells. The ferritin self-assembled into nanoparticles, each bearing eight copies of the spike protein trimer. The team purified the spike/ferritin particles and injected them into mice.

ALSO READ: Nanomaterial-Based Biosensing Platform That Detects Antibodies Of Virus

After a single immunization, mice produced neutralizing antibody titers that were at least two times higher than those in convalescent plasma from Covid-19 patients, and significantly higher than those in mice immunized with the spike protein alone. A second immunization 21 days later produced even higher antibody levels.

Although these results must be confirmed in human clinical trials, they suggest that the spike/ferritin nanoparticles may be a viable strategy for single-dose vaccination against Covid-19, the researchers said. (IANS)


Popular

voa

The Indian ships will spend more than two months in the region, the navy said in a statement.

NEW DELHI - India Navy sending four ships for exercises and port visits with the Philippines, Vietnam, Singapore, Indonesia and Australia to strengthen cooperation in the Indo-Pacific region, its navy said Wednesday, as China's maritime power grows in the area.

The Indian ships will spend more than two months in the region, the navy said in a statement.

Keep Reading Show less

The UK government on Thursday announced that it will move India from the red to the amber list on Sunday, in the country's latest update to the 'Red-Amber-Green' traffic light ratings for arrivals into England amid the Covid-19 pandemic.

This means the visit visas for the UK from India are open, in addition to other long-term visas that have remained open. But travellers from India arriving in England can complete a 10-day quarantine at home or in the place they are staying (not mandatorily quarantine in a managed hotel).

Keep Reading Show less
ians

Pakistan has failed miserably to protect Hindus, their interests.

A Hindu temple in Pakistan's Punjab province was reportedly vandalized by hundreds of people after a nine-year-old Hindu boy, who allegedly urinated at a local seminary, received bail, a media report said on Thursday.

According to the Dawn news report, the incident took place on Wednesday in Bhong town, about 60 km from Rahim Yar Khan city.

Besides the vandalization, the mob also blocked the Sukkur-Multan Motorway (M-5), the report added.

Citing sources, Dawn news said that a case was registered against the minor on July 24 based on a complaint filed by a cleric, Hafiz Muhammad Ibrahim, of the Darul Uloom Arabia Taleemul Quran.

The sources said that "some Hindu elders did tender an apology to the seminary administration saying the accused was a minor and mentally challenged".

But, when a lower court granted him bail a few days ago, some people incited the public in the town on Wednesday and got all shops there closed in protest, the report quoted the sources as further saying.

A video clip showing people wielding clubs and rods storming the temple and smashing its glass doors, windows, lights, and damaging the ceiling fans went viral on social media.

Also Read: Hindu Woman Axed To Death In Pakistan

Keep reading... Show less