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Skin exposure to ultra-violet B, also known as UVB Light radiation from the Sun can alter the gut microbiome in humans — possibly via vitamin D which can help explain the protective role of UVB in inflammatory diseases like Multiple Sclerosis and Inflammatory Bowel Disease.
Sun exposure, vitamin D levels and the mix of bacteria in our gut are each associated with risk of inflammatory conditions like MS and IBD, said scientists from University of British Columbia.
Exposure to UVB in sunlight is well-known to drive vitamin D production in the skin, and recent studies suggest that vitamin D alters the human gut microbiome.
However, that UVB, therefore, causes gut microbiome changes, via vitamin D production, has so far been shown only in rodents.
In a new clinical pilot study, researchers tested the effect of skin UVB exposure on the human gut microbiome.
Healthy female volunteers were given three, one-minute sessions of full-body UVB exposure in a single week.
Before and after treatment, stool samples were taken for analysis of gut bacteria – as well blood samples for vitamin D levels.
Skin UVB exposure significantly increased gut microbial diversity, but only in subjects who were not taking vitamin D supplements.
“Prior to UVB exposure, these women had a less diverse and balanced gut microbiome than those taking regular vitamin D supplements,” reported Professor Bruce Vallance, who led the University of British Columbia study.
“UVB exposure boosted the richness and evenness of their microbiome to levels indistinguishable from the supplemented group, whose microbiome was not significantly changed”.
Published in Frontiers in Microbiology, the analysis suggests that vitamin D mediates the change — which could help explain the protective effect of UVB light in inflammatory diseases like MS and IBD.
The largest effect was an increase in the relative abundance of “Lachnospiraceae” bacteria after the UVB light exposures.
This indicates that vitamin D at least partly mediates UVB-induced gut microbiome changes.
The study is not designed to show the exact mechanism by which the microbiome changes occur, but both UVB and vitamin D are known to influence the immune system.
“It is likely that exposure to UVB light somehow alters the immune system in the skin initially, then more systemically, which in turn affects how favourable the intestinal environment is for the different bacteria,” suggests Vallance.
The results have implications for people who are undergoing UVB phototherapy, said scientists. (IANS)
Some women say they experienced period changes after getting a Covid-19 vaccination. While the reported changes are short-lived, research into this possible adverse reaction remains critical to the success of the vaccination programme, according to an editorial published in The BMJ.
"A link between menstrual changes after Covid-19 vaccination is plausible and should be investigated," wrote Dr Victoria Male, a reproductive specialist at Imperial College London, in the editorial. Reports of menstrual changes after Covid-19 vaccination have been made for both mRNA and adenovirus-vectored vaccines, she added, suggesting that, if there is a connection, it is likely to be a result of the immune response to vaccination, rather than to a specific vaccine component, she said.
While changes to periods or unexpected vaginal bleeding are not listed as common side effects of Covid-19 vaccination, more than 30,000 such reports have been made to the UK Medicines and Healthcare Products Regulatory Agency (MHRA) surveillance scheme for adverse drug reactions till September 2. However, most people find that their period returns to normal the following cycleand, importantly, there is no evidence that Covid-19 vaccination adversely affects fertility, Male said.
Most people find that their period returns to normal the following cycleand, importantly, there is no evidence that Covid-19 vaccination adversely affects fertility, Male said. | Photo by Hakan Nural on Unsplash
The MHRA states that its surveillance data does not support a link between changes to menstrual periods and Covid-19 vaccines, since the number of reports is low in relation to both the number of people vaccinated and the prevalence of menstrual disorders generally. However, the way in which data is collected makes firm conclusions difficult, Male noted.
She argued that approaches better equipped to compare rates of menstrual changes in vaccinated versus unvaccinated populations are needed, and pointed to the study that the US National Institutes of Health (NIH) has undertaken. Indeed, the menstrual cycle may be affected by the body's immune response to the virus itself, with one study showing menstrual disruption in around a quarter of women infected with SARS-CoV2.
If a link between vaccination and menstrual changes is confirmed, this will allow individuals seeking vaccination to plan in advance for potentially altered cycles, Male contended. In the meantime, clinicians must encourage their patients to report any changes to periods or unexpected vaginal bleeding after vaccination. And anyone reporting a change in periods persisting over a number of cycles, or new vaginal bleeding after the menopause, should be managed according to the usual clinical guidelines for these conditions, she suggested. (IANS/MBI)
Keywords: vaccine, menstrual cycle, period, covid, women, health
A garage sale in the 21st century needs a tech-savvy platform. This is where Poshmark comes into the picture, the platform with a community of over 2.5 million Canadians has products listed with over half a billion dollars in value by their users.
It began expanding outside of the United States in Canada in May 2019 and has now launched in India. So its become simple and easy for anyone to sell items from their closet, enabled by a full suite of end-to-end seller tools and services, including seamless listing, merchandising, promotion, pricing, and shipping. Indian consumers will be able to join Social marketplace Poshmark, Inc. (Nasdaq: POSH), a booming community of more than 80 million users and a vibrant network of millions of shoppable closets to make money, save money, connect with others, and foster entrepreneurship.
The platforms scalable model and infrastructure enables continued expansion to new countries and categories in the future. | Photo by Duy Hoang on Unsplash
"As an Indian who grew up exploring the marketplaces of Old Delhi, I know firsthand how important it is to come together and connect as part of the shopping experience. I am confident that our social marketplace will resonate with Indian consumers and allow us to build a thriving and successful community here." The platform's scalable model and infrastructure enables continued expansion to new countries and categories in the future. (IANS/ MBI)
(Article originally written by: N. Lothungbeni Humtsoe)
Keywords: Clothes, garage, Poshmark, India, Old Delhi, social marketplace
Great historic events that have shaped the world and changed the outlines of countries are often not recorded in memory, or so we think. Wars made sure to destroy evidence and heritage, and the ones who survived told the tale of what really happened. Folklore, albeit through oral tradition kept alive many such stories, hidden in verse, limericks, and rhymes.
Ringa-ringa-roses, a common playtime rhyme among children across the world, is an example of folklore that has survived for many centuries. It tells the story of the The Great Plague of London which ravaged the city between 1665-1666.
The Plague broke out from improper disposal of garbage and poor sewage conditions. Fleas from the rats that lived in the sewers spread the disease that killed more than half of London's population. Many people fled from their homes as there was no medicine available for those who were infected.
Beak-shaped masks worn during the Great Plague of London Image source: wikimedia commons
It was around this time that masks began to be invented. The first masks were shaped like beaks, and were worn not to protect the wearer from the disease, but to the prevent them from being able to smell the decay and death around them, which they called 'miasma'. The beaks were filled with floral herbs that allowed doctors and nurses to tend to the sick without being reviled from the smell.
Children are often seen forming circles by holding hands and reciting loudly,
Pockets full of posies
We all fall down"
An illustration of the Great Plague of London, 1665 Image source: wikimedia commons
When the last line is sung, they break the circle and fall down. The roses and posies are believed to be the preferred fragrances inside the masks, and a single sneeze (a-tishoo) was enough to infect the one who was exposed to the disease. Consequently, they fell down, ill, and later died.
An alternative version of this rhyme is sung about the fall of Hiroshima and Nagasaki in the aftermath of World War II. The roses and posies are interchanged with geranium and uranium, to symbolise what was used in the atomic bomb. But this version is not as famous the original.
Keywords: Rhymes, Ringa-ringa-roses, Great Plague of London, WWII, Hiroshima, Nagasaki, Folklore