Tuesday November 12, 2019

Skinny Genes Holds The Key ‘to Being Slim’

"If we can find the genes that prevent them from putting on weight, we may be able to target those genes to find new weight loss strategies and help people who do not have this advantage," Farooqi added

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Women use Bizarre Ways to Look Slim
Women use Bizarre Ways to Look Slim. Pixabay

It’s not only healthy food and exercise, but skinny genes that hold the key ‘to staying slim’, say researchers who found that slim people have a genetic advantage when it comes to maintaining their weight.

The study, led by University of Cambridge researchers, looked at why some people manage to stay thin while others easily gain weight.

They found that thin people had a much lower genetic risk score — they had fewer genetic variants that we know increase a person’s chances of being overweight.

“This research shows for the first time that healthy thin people are generally thin because they have a lower burden of genes that increase a person’s chances of being overweight and not because they are morally superior, as some people like to suggest,” said Professor Sadaf Farooqi from the varsity.

“It’s easy to rush to judgement and criticise people for their weight, but the science shows that things are far more complex. We have far less control over our weight than we might wish to think,” he added.

Your slim figure is because of your skinny genes. Pixabay

In the study, published in the journal PLOS Genetics, the researchers compared the DNA of some 14,000 people — 1,622 thin volunteers, 1,985 severely obese people and 10,433 normal weight controls.

Three out of four people had a family history of being thin and healthy and the team found some genetic changes that were significantly more common in thin people, which they say may allow them to pinpoint new genes and biological mechanisms that help people stay thin.

To see what impact these genes had on an individual’s weight, the researchers added up the contribution of the different genetic variants to calculate a genetic risk score.

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“As anticipated, we found that obese people had a higher genetic risk score than normal weight people, which contributes to their risk of being overweight. The genetic dice are loaded against them,” explained Ines Barroso’s from the Wellcome Sanger Institute.

“If we can find the genes that prevent them from putting on weight, we may be able to target those genes to find new weight loss strategies and help people who do not have this advantage,” Farooqi added. (IANS)

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Researchers Find That Discount on Medical Drugs Can Make you Purchase Them More

The study used Canadian national pharmacy data from 2.82 million prescriptions for 89 different medications where brand-name drug discount cards were used and compared

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Discount
While Discount cards decreased some patients' out-of-pocket costs by 7 per cent on an average, the study surprisingly found that many patients who filled prescriptions using a card were worse-off financially as a result. Pixabay

Researchers have found that brand-name Drug Discount cards are leading to higher healthcare spending in Canada.

Brand-name drug discount cards — also known as co-pay cards — are coupons offered by drug manufacturers to encourage patients to use brand-name drugs even after much cheaper generics became available.

Despite often boosting savings for customers, the study’s findings published in the Canadian Medical Association Journal show that drug discount cards actually increased private insurer costs by 46 per cent and public insurer costs by 1.3 per cent, compared to patients purchasing generics instead.

“We know that generic drugs are equally effective for the vast majority of patients. Given that, I believe these cards are leading to unjustifiable increases in health care costs,” said the study’s lead author Michael Law from the University of British Columbia in Canada.

While discount cards decreased some patients’ out-of-pocket costs by 7 per cent on an average, the study surprisingly found that many patients who filled prescriptions using a card were worse-off financially as a result.

This wasn’t the case for all drugs, but in some cases patients could pay up to $10 more out-of-pocket when using a discount card.

The study used Canadian national pharmacy data from 2.82 million prescriptions for 89 different medications where brand-name drug discount cards were used and compared the costs of these prescriptions to matched generic equivalents.

Discount
Researchers have found that brand-name Drug Discount cards are leading to higher healthcare spending in Canada. Pixabay

The researchers said that patients, their clinicians and employers should be aware of the impact that brand-name discount cards have on the healthcare system.

For example, the increased costs to private insurers will likely be passed on to the patients and their employers in the form of increased insurance premiums.

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“Regardless of whether they hold insurance, patients should check the relative price between brand-name drugs with a discount card and the equivalent generics at their pharmacy,” said Law. (IANS)