Tuesday March 26, 2019

Losing Just 6 Hours of Sleep May Spike up Diabetes Risk: Study

During the sleep/wake period, the animals also had limited opportunity for physical activity

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Soothing colours, right scent aid sound sleep. Pixabay

Being deprived of sleep for just six hours or a single night may affect the liver’s ability to produce glucose and process insulin, increasing the risk of metabolic diseases such as fatty liver and Type-2 diabetes, warns a study.

Sleep deprivation has been associated with eating more, moving less and having a higher risk of developing Type-2 diabetes.

However, “it was not clear whether glucose intolerance was due to the changes in food intake or energy expenditure or to the sleep deprivation itself,” explained a team of researchers from Toho University in Japan.

In the study done over mice, blood glucose levels were found significantly higher in the sleep deprivation group than controls after one six-hour session of wakefulness.

Triglyceride (fat) levels and the production of glucose in the liver also increased in the sleep deprivation group after a single wake period.

Elevated liver triglycerides are associated with insulin resistance, or the inability of the body to process insulin properly.

Diabetes
Representational image. Pixabay

In addition, lack of sleep changed the expression of enzymes that regulate metabolism in the liver in the sleep deprivation group.

These findings suggest that “intervention studies designed to prevent sleep deprivation-induced hepatic steatosis and insulin resistance should be performed in the future,” the researchers noted.

For the study, published in the American Journal of Physiology — Endocrinology and Metabolism, the team examined two groups of mice.

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One group was kept awake for six hours each night (“sleep deprivation”), while the control group was allowed to sleep as desired.

The team offered unlimited high-fat food and sugar water — mimicking lifestyle-related food choices that people make — to both groups prior to the study.

During the sleep/wake period, the animals also had limited opportunity for physical activity. (IANS)

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Cardiovascular Events Cause 58% Deaths Among Diabetics

The medicine likewise helps lower the amount of sodium in the body and reduce triglyceride levels and blood pressure

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Diabetes
Representational image. Pixabay

Fifty-eight percent of deaths among people with type 2 diabetes are due to cardiovascular events, a leading Mexican expert has said.

“Patients who live with this disease have a greater risk of premature death or disability derived from cardiovascular events,” Hector Sanchez Mijangos, President of the Mexican Diabetes Federation, told Efe news.

The specialist said that the high glucose levels associated with diabetes damage blood vessels, resulting in problems with blood pressure and vision, joint pain and other maladies.

Data from the World Health Organization indicate that more 442 million people suffer from type 2 diabetes.

Mexico’s Health Secretariat has found that while roughly 13 million inhabitants of the Aztec nation are living with diabetes, only half of those afflicted know they have the disease.

In 2015 alone, according to Mijangos, there were more than 98,000 premature deaths in Mexico related to diabetes and the average age of those who died was 66.7 years old.

Diabetes
Representational image. Pixabay

“This is regrettable, because these people could have lived roughly another 15 years,” he said.

According to the 2012 National Health and Nutrition Survey, only 25 percent of Mexicans suffering with diabetes are managing their condition adequately.

That figure illustrates “why our greatest challenge continues to be access and adherence to treatment”, Mijangos said.

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To improve treatment options, Mexican health authorities in January issued an approval for the use of canagliflozin, a drug that helps reduce the amount of blood glucose reabsorbed by the kidneys, which in turns causes more glucose to be eliminated through urination.

“With this medicine, a person can lose 100 milligrams of glucose per day as well as about 400 kilocalories (4,000 calories) a day, which also helps with weight loss,” Mijangos said.

The medicine likewise helps lower the amount of sodium in the body and reduce triglyceride levels and blood pressure.

A scientific trial involving more than 10,000 patients worldwide showed that when combined with conventional treatment, canagliflozin can reduce the incidence of cardiovascular events by up to 18 percent. (IANS)