Wednesday January 23, 2019

Smoking during pregnancy linked to asthma severity in kids

Prenatal tobacco smoke exposure was associated with a 2.5 times increase in odds of having airflow obstruction in children with asthma

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  • Smoking during pregnancy can be very dangerous
  • It can lead to asthma and poor lung function in the baby
  • It also can have serve effects on the health of the mother

Women who smoke while pregnant contribute to the severity of asthma and poor lung function in their children warns a study.

The findings published in the journal CHEST suggest that tobacco smoke exposure during pregnancy is more strongly associated with worse lung function than current, ongoing exposure in school-aged children with asthma.

Smoking during pregnancy can be unhealthy for the child.

“This study implicates maternal smoking in pregnancy as the period of second-hand exposure that is more strongly associated with worse lung function in asthmatic children,” said lead investigator Stacey-Ann Whittaker Brown from Icahn School of Medicine at Mount Sinai, New York.

“Maternal smoking in pregnancy may set children with asthma on a trajectory of poor lung function in later childhood, and other studies suggest this effect may be lifelong,” Whittaker Brown said.

Investigators analysed the relationship between lung function and the type of second-hand smoke exposure in a representative sample of school-aged children aged six to 11 years.

Also Read: Why you should avoid Paracetamol during pregnancy

The sample consisted of 2,070 children who participated in the 2007-2012 National Health and Nutrition Examination Survey (NHANES) in the US.

Detailed information about ongoing second-hand smoke exposure as well as parental self-reported exposure prior to birth was obtained.

During the study period, lung function was measured using spirometry, and exposure to smoking was assessed through levels of cotinine in the blood, a marker of the extent of current second-hand smoke exposure. Thus, investigators were able to distinguish clearly between exposure in pregnancy and ongoing second-hand smoke exposure.

Protein responsible for postpartum depression in pregnancy found
Smoking during pregnancy is very dangerous. IANS

Nearly 10 percent of both children with and without asthma in the sample had reduced lung function.

Investigators found that current tobacco smoke exposure was independently associated with airflow obstruction in school-aged children, although the extent of the association was small.

However, prenatal tobacco smoke exposure was associated with a 2.5 times increase in odds of having airflow obstruction in children with asthma, the study said. IANS

Next Story

Protein Identified Enables New Drugs to Increase ‘Good Cholesterol’ Levels

Importantly, ORP2 could also be targeted to fight cancer. 

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ORP2 could offer a new strategic line of research and possibly succeed where the use of statins in this area hasn't, Yang noted.

Researchers have identified a protein, known as ORP2, responsible for transporting cholesterol inside cells that opens the way for new drugs to increase the body’s ‘good cholesterol’ levels.

ORP2 can increase the amount of cholesterol in cells, a process called cholesterol efflux. We think this pathway will be very important for the development of a drug to increase this good cholesterol, said Rob Yang, Professor from the University of New South Wales in Australia.

Until now, drugs including statins have targeted bad cholesterol (LDL) by inhibiting its synthesis in the liver in an effort to mitigate the risk of heart disease and stroke.

However, while statins are effective at lowering LDL levels, they do little to increase the levels of good cholesterol (HDL) and there is no other drug in use that can significantly boost the human body’s HDL levels.

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Researchers have identified a protein, known as ORP2, responsible for transporting cholesterol inside cells that opens the way for new drugs to increase the body’s ‘good cholesterol’ levels. . VOA

Up to 90 per cent of a cell’s cholesterol is found at the cell’s plasma membrane, said the study published in the journal Molecular Cell.

“Knowing the molecules that deliver cholesterol to the plasma membrane itself is a huge step forward. The transport of cholesterol to the plasma membrane is the key to the generation of HDL.

If such a drug could be developed, it would not replace statins, but would be used complementarily, with one drug used to reduce the bad cholesterol and the other to increase levels of the good, Yang suggested.

Also Read: Number of Students Opting for Science or Tech Are On Rise in India

Importantly, ORP2 could also be targeted to fight cancer.

Cancer, U.S.

Importantly, ORP2 could also be targeted to fight cancer.

The rampant and uncontrolled growth of cells that characterises cancer could be stopped in its tracks by reducing the amount of cholesterol produced.

ORP2 could offer a new strategic line of research and possibly succeed where the use of statins in this area hasn’t, Yang noted. (IANS)