Thursday December 12, 2019

Reduce the Spread of Cancer With this Protein, According to Research by University of Guelph, Ontario

Researchers have discovered a new protein that could reduce the spread of cancer by binding the cancer cells together and allowing them to invade tissues

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Cancer rate declined generally but increased in this particular age group. IANS.
Cancer rate declined generally but increased in this particular age group. IANS.

New York, Nov 19: Researchers have discovered a new protein that could reduce the spread of cancer by binding the cancer cells together and allowing them to invade tissues.

The study conducted by the researchers from University of Guelph, Ontario, has identified a protein called cadherin-22, a potential factor in cancer metastasis or the spread of cancer.

The protien also decreased the adhesion and invasion rate of breast and brain cancer cells by up to 90 per cent.

“Cadherin-22 could be a powerful prognostic marker for advanced cancer stages and patient outcomes,” said lead author Jim Uniacke, a professor at the varsity.

“If you can find a treatment or a drug that can block cadherin-22, you could potentially prevent cancer cells from moving, invading and metastasizing.”

The study, published in the journal Oncogene, looks specifically at hypoxia, a condition in which the tissues receive less oxygen.

The researchers found that it is precisely under conditions of low oxygen that cancer cells trigger the production of cadherin-22, putting in motion a kind of protein boost that helps bind cells together, enhancing cellular movement, invasion and likely metastasis.

Studying breast and brain cancer cells in a hypoxia incubator, the researchers discovered that cadherin-22 is involved in this process to enable the spread of cancer cells.

For both cancer types, the research team used molecular tools to reduce the amount of cadherin-22.

They placed the human cancer cells into the incubator and lowered the oxygen to a level comparable to that in a tumour. The cells failed to spread.

“One very powerful and common tool in cell and molecular biology labs is, you can remove a protein from a cell and see how that cell behaves without it.

“We culture our cancer cells in this very low-oxygen environment, and they start behaving like they are inside a low-oxygen tumour,” Uniacke added. (IANS)

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Regular Use Of Hair Dye And Straightener May Increase The Risk Of Breast Cancer

An intriguing finding was the association between the use of chemical hair straighteners and breast cancer

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Breast cancer pink ribbon
Breast cancer survival rates are rising as screening and treatment improve. Pixabay

Researchers have found that women who use permanent hair dye and chemical hair straighteners have a higher risk of developing breast cancer than women who don’t use these products.

The study, published in the International Journal of Cancer, suggests that this risk increased with more frequent use of these chemical hair products.

“Researchers have been studying the possible link between hair dye and cancer for a long time, but results have been inconsistent,” said study author Alexandra White from National Institute of Environmental Health Sciences (NIEHS) in US.

“In our study, we see a higher risk associated with hair dye use, and the effect is stronger in African American women, particularly those who are frequent users,” White said.

Using data from 46,709 women in the Sister Study, researchers at NIEHS, found that women who regularly used permanent hair dye in the year prior to enrolling in the study were nine per cent more likely than women who didn’t use hair dye to develop breast cancer.

Among African American women, using permanent dyes every five to eight weeks or more was associated with a 60 per cent increased risk of breast cancer as compared with an eight per cent increased risk for white women.

The research team found little to no increase in breast cancer risk for semi-permanent or temporary dye use.

Permanent hair dye risks breast cancer
Women who regularly use permanent hair dye could be increasing their risk of breast cancer up to 60 percent, according to scientists writing in the International Journal of Cancer. Pixabay

An intriguing finding was the association between the use of chemical hair straighteners and breast cancer.

The researchers found that women who used hair straighteners at least every five to eight weeks were about 30 per cent more likely to develop breast cancer.

While the association between straightener use and breast cancer was similar in African American and white women, straightener use was much more common among African American women, the study said.

The researchers cautioned that although there is some prior evidence to support the association with chemical straighteners, these results need to be replicated in other studies.

ALSO READ: Protein Deficiency Ordinary Among Indians: Experts

When asked if women should stop dyeing or straightening their hair, study co-author Dale Sandler, “We are exposed to many things that could potentially contribute to breast cancer, and it is unlikely that any single factor explains a woman’s risk.

“While it is too early to make a firm recommendation, avoiding these chemicals might be one more thing women can do to reduce their risk of breast cancer,” Sandler said.(IANS)