Friday December 14, 2018

Reduce the Spread of Cancer With this Protein, According to Research by University of Guelph, Ontario

Researchers have discovered a new protein that could reduce the spread of cancer by binding the cancer cells together and allowing them to invade tissues

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Cancer rate declined generally but increased in this particular age group. IANS.
Cancer rate declined generally but increased in this particular age group. IANS.
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New York, Nov 19: Researchers have discovered a new protein that could reduce the spread of cancer by binding the cancer cells together and allowing them to invade tissues.

The study conducted by the researchers from University of Guelph, Ontario, has identified a protein called cadherin-22, a potential factor in cancer metastasis or the spread of cancer.

The protien also decreased the adhesion and invasion rate of breast and brain cancer cells by up to 90 per cent.

“Cadherin-22 could be a powerful prognostic marker for advanced cancer stages and patient outcomes,” said lead author Jim Uniacke, a professor at the varsity.

“If you can find a treatment or a drug that can block cadherin-22, you could potentially prevent cancer cells from moving, invading and metastasizing.”

The study, published in the journal Oncogene, looks specifically at hypoxia, a condition in which the tissues receive less oxygen.

The researchers found that it is precisely under conditions of low oxygen that cancer cells trigger the production of cadherin-22, putting in motion a kind of protein boost that helps bind cells together, enhancing cellular movement, invasion and likely metastasis.

Studying breast and brain cancer cells in a hypoxia incubator, the researchers discovered that cadherin-22 is involved in this process to enable the spread of cancer cells.

For both cancer types, the research team used molecular tools to reduce the amount of cadherin-22.

They placed the human cancer cells into the incubator and lowered the oxygen to a level comparable to that in a tumour. The cells failed to spread.

“One very powerful and common tool in cell and molecular biology labs is, you can remove a protein from a cell and see how that cell behaves without it.

“We culture our cancer cells in this very low-oxygen environment, and they start behaving like they are inside a low-oxygen tumour,” Uniacke added. (IANS)

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Here’s How Exercise Can Help Breast Cancer Survivors

Among those who completed the program, those who received the lifestyle intervention were about 50 per cent more likely to have disease-free survival than those who received the general recommendations

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How exercise can help breast cancer survivors. Pixabay

Survivors of early-stage breast cancer who exercise and eat a healthy diet are more likely to lose weight and experience higher rates of disease-free survival, a new study suggests.

The research is based on an examination of a lifestyle intervention that included exercise, diet, and at least one other component such as counselling, stress management, and discontinuing tobacco smoking.

The study showed that obesity and low physical activity are associated with higher risks of developing breast cancer, as well as an increased risk of recurrence and reduced survival.

“Lifestyle intervention might improve the prognosis of breast cancer patients if adherence is high,” said Wolfgang Janni from the University of Ulm in Germany.

“Many breast cancer survivors would like to contribute actively to improving their prognosis, and guiding them on lifestyle factors that can help them control weight is one possible way to positively impact patient outcomes,” said Janni.

For the study, the researchers enrolled 2,292 women among which all had a body mass index of 24 or higher.

Cancer
Cancer Ribbon. Pixabay

Some women were randomly assigned to receive either telephone-based lifestyle intervention for two years while others received general recommendations for a healthy lifestyle alone.

Those who received the telephone calls were given advice on how to improve their diets, lower fat intake, increase physical activity, achieve moderate weight loss and other tips that were geared to their specific needs.

Findings, presented at the 2018 San Antonio Breast Cancer Symposium in the US, demonstrated that patients in the lifestyle intervention arm had lost an average of one kg, while the patients in the control group had gained an average of 0.95 kg.

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Overall, 1,477 patients completed the lifestyle intervention. Those who completed the program had a 35 per cent higher rate of disease-free survival than those who began the program but did not complete it.

Among those who completed the program, those who received the lifestyle intervention were about 50 per cent more likely to have disease-free survival than those who received the general recommendations. (IANS)