Monday October 15, 2018

Reduce the Spread of Cancer With this Protein, According to Research by University of Guelph, Ontario

Researchers have discovered a new protein that could reduce the spread of cancer by binding the cancer cells together and allowing them to invade tissues

0
//
76
Cancer rate declined generally but increased in this particular age group. IANS.
Cancer rate declined generally but increased in this particular age group. IANS.
Republish
Reprint

New York, Nov 19: Researchers have discovered a new protein that could reduce the spread of cancer by binding the cancer cells together and allowing them to invade tissues.

The study conducted by the researchers from University of Guelph, Ontario, has identified a protein called cadherin-22, a potential factor in cancer metastasis or the spread of cancer.

The protien also decreased the adhesion and invasion rate of breast and brain cancer cells by up to 90 per cent.

“Cadherin-22 could be a powerful prognostic marker for advanced cancer stages and patient outcomes,” said lead author Jim Uniacke, a professor at the varsity.

“If you can find a treatment or a drug that can block cadherin-22, you could potentially prevent cancer cells from moving, invading and metastasizing.”

The study, published in the journal Oncogene, looks specifically at hypoxia, a condition in which the tissues receive less oxygen.

The researchers found that it is precisely under conditions of low oxygen that cancer cells trigger the production of cadherin-22, putting in motion a kind of protein boost that helps bind cells together, enhancing cellular movement, invasion and likely metastasis.

Studying breast and brain cancer cells in a hypoxia incubator, the researchers discovered that cadherin-22 is involved in this process to enable the spread of cancer cells.

For both cancer types, the research team used molecular tools to reduce the amount of cadherin-22.

They placed the human cancer cells into the incubator and lowered the oxygen to a level comparable to that in a tumour. The cells failed to spread.

“One very powerful and common tool in cell and molecular biology labs is, you can remove a protein from a cell and see how that cell behaves without it.

“We culture our cancer cells in this very low-oxygen environment, and they start behaving like they are inside a low-oxygen tumour,” Uniacke added. (IANS)

Click here for reuse options!
Copyright 2017 NewsGram

Next Story

Losing Weight Can Help Lower The Risk of Breast Cancer For Post-menopausal Women

"These findings, taken together, provide strong correlative evidence that a modest weight loss programme can impact breast cancer,"

0
Photo: neqotkukhealthcenter.ca

Women, please take a note. Losing weight can help lower the risk of developing breast cancer in the post-menopausal stage, a new study has found.

The study, published in the journal CANCER, found that among post-menopausal women, participants who lost weight had a lower risk of developing invasive breast cancer than those who maintained or gained weight.

“Our study indicates that moderate, relatively short-term weight reduction was associated with a statistically significant reduction in breast cancer risk for postmenopausal women,” said co-author Rowan Chlebowski from the City of Hope National Medical Center in Duarte, California.

Although obesity has been strongly related to breast cancer risk, studies examining whether weight loss might reduce postmenopausal women’s risk have provided mixed results, the researchers said.

For the study, the research team analysed information on 61,335 women participating in the World Health Initiative Observational Study who had no prior history of breast cancer and had normal mammogram results.

Breast Cancer
Weight loss may lower breast cancer risk for post-menopausal women. Pixabay

The participant’s body weight, height and body mass index were assessed at the start of the study and again three years later.

The team found that during an average follow-up of 11.4 years, there were 3,061 new cases of invasive breast cancer diagnosed.

Also Read- Actor Sushant Singh Rajput Becomes Brand Ambassador of Bata

“These are observational results, but they are also supported by randomised clinical trial evidence from the Women’s Health Initiative Dietary Modification trial where, in a randomised clinical trial setting, adopting a low-fat dietary pattern that was associated with a similar magnitude of weight loss resulted in a significant improvement in breast cancer overall survival,” Chlebowski said.

“These findings, taken together, provide strong correlative evidence that a modest weight loss programme can impact breast cancer,” he noted. (IANS)