Wednesday February 21, 2018

Reduce the Spread of Cancer With this Protein, According to Research by University of Guelph, Ontario

Researchers have discovered a new protein that could reduce the spread of cancer by binding the cancer cells together and allowing them to invade tissues

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Cancer rate declined generally but increased in this particular age group. IANS.
Cancer rate declined generally but increased in this particular age group. IANS.
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New York, Nov 19: Researchers have discovered a new protein that could reduce the spread of cancer by binding the cancer cells together and allowing them to invade tissues.

The study conducted by the researchers from University of Guelph, Ontario, has identified a protein called cadherin-22, a potential factor in cancer metastasis or the spread of cancer.

The protien also decreased the adhesion and invasion rate of breast and brain cancer cells by up to 90 per cent.

“Cadherin-22 could be a powerful prognostic marker for advanced cancer stages and patient outcomes,” said lead author Jim Uniacke, a professor at the varsity.

“If you can find a treatment or a drug that can block cadherin-22, you could potentially prevent cancer cells from moving, invading and metastasizing.”

The study, published in the journal Oncogene, looks specifically at hypoxia, a condition in which the tissues receive less oxygen.

The researchers found that it is precisely under conditions of low oxygen that cancer cells trigger the production of cadherin-22, putting in motion a kind of protein boost that helps bind cells together, enhancing cellular movement, invasion and likely metastasis.

Studying breast and brain cancer cells in a hypoxia incubator, the researchers discovered that cadherin-22 is involved in this process to enable the spread of cancer cells.

For both cancer types, the research team used molecular tools to reduce the amount of cadherin-22.

They placed the human cancer cells into the incubator and lowered the oxygen to a level comparable to that in a tumour. The cells failed to spread.

“One very powerful and common tool in cell and molecular biology labs is, you can remove a protein from a cell and see how that cell behaves without it.

“We culture our cancer cells in this very low-oxygen environment, and they start behaving like they are inside a low-oxygen tumour,” Uniacke added. (IANS)

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Night shifts may increase cancer risk

A positive association between night shifts and risk of cancer

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Night shifts increase cancer risk. Pexels
Night shifts increase cancer risk. Pexels
  • Long-term night shift work among women increased the risk of cancer by 19%.
  • A meta-analysis using using international data from 61 articles comprising 114,628 cancer cases and 3,909,152 participants.
  • These studies found an association between long-term night shift work and risk of 11 types of cancer.

Women who work overnight have a comparatively high risk of developing cancer than women who do not, say researchers. An analysis of international data has confirmed an association between night-shifts and cancer.

“Our study indicates that night shift work serves as a risk factor for common cancers in women,” said Xuelei Ma, co-author of the study from West China Medical Center of Sichuan University in Chengdu, China.

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Findings

These studies found an association between long-term night shift work and risk of 11 types of cancer. Wikimedia commons
These studies found an association between long-term night shift work and risk of 11 types of cancer. Wikimedia commons
  • Long-term night shift work among women increased the risk of cancer by 19 percent.
  • Nurses (working in night shifts) had the highest risk of breast cancer, of all the occupations analysed.
  • The population of women working on night shifts have an increase risk of skin (41%), breast (32%) and gastrointestinal cancer (18%).
  • Among female nurses alone, those who worked the night shift had an increased risk of breast (58%), gastrointestinal (35%) and lung cancer (28%).

Methodology

  • A meta-analysis using data from 61 articles comprising 114,628 cancer cases and 3,909,152 participants from North Amercia, Europe, Australia and Asia.
  • The articles consisted of 26 cohort studies, 24 case-control studies and 11 nested case-control studies.
  • These studies found an association between long-term night shift work and risk of 11 types of cancer.

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“Nurses that worked the night shift were of a medical background and may have been more likely to undergo screening examinations,” the researcher suggested.

The results might help establish and implement effective measures to protect female night shifters. Pixabay
The results might help establish and implement effective measures to protect female night shifters. Pixabay

“Long-term night shift workers should have regular physical examinations and cancer screenings,” Ma noted.

The study was published in journal Cancer Epidemiology. (IANS)