Never miss a story

Get subscribed to our newsletter


×
Higher levels of inflammation may in turn increase risk for heart diseases (IANS)

Stem cells may potentially be used as a “one-and-done” approach to restore function in people with heart-failure, a study has found.

Reported in the journal Nature Biotechnology, the study showed human stem cell treatment can possibly return the hearts’ functioning to better than 90 per cent of normal in macaque monkeys with heart attacks.


Heart-failure that causes nearly 10 million deaths worldwide, is a condition caused by lack of blood flow. The stem cells will help “form new muscle that will integrate into heart so it may pump vigorously again,” said Charles “Chuck” Murry, Professor at the University of Washington.

“Our findings show that human embryonic stem cell-derived cardiomyocytes can re-muscularise infarcts in macaque monkey hearts and, in doing so, reduce scar size and restore a significant amount of heart function. This should give hope to people with heart disease,” Murry said.

For the study, the team induced experimental heart attacks in macaque monkeys.

Two weeks later, the researchers took heart cells that they had grown from embryonic human embryonic stem cells and injected them into and around the young scar tissue. Each animal received roughly 750 million of these human embryonic stem cell-derived cardiomyocytes.


Representational image. Pixabay

At four weeks after treatment, the ejection fraction in the treated animals rose to 49.7 per cent, about half-way back to normal, as compared to the untreated control animals, which remained unchanged at about 40 per cent.

MRI scans showed that new heart muscle had grown within what had been scar tissue in the treated hearts, while no new muscle was seen in the untreated animals.

Moreover, the human heart cells had also formed new muscle tissue in the damaged region. The new muscle tissue had replaced 10 per cent to 29 per cent of the scar tissue, integrated with the surrounding healthy tissue and developed into mature heart cells, the researchers said.

Also Read: Virtual Reality Tech Transforming Heart Treatments

Murry said that the research aims to develop a treatment that could be given to people shortly after a heart attack to prevent heart failure.

Because heart cells are long-lived there should be no need for additional treatments, he said. The transplanted stem cells would also be genetically altered to reduce the risk of immune rejection, which often complicates organ transplantation.

“What we hope to do is create a “one-and-done” treatment with frozen “off-the-shelf” cells that, like O-negative blood, can go into any recipient with only moderate immune suppression,” Murry said. (IANS)


Popular

Unsplash

Feminism itself is nothing but a simple movement that pursues equal rights for women (including transwomen) and against misogyny both external and internal.

"In India, to be born as a man is a crime, to question a woman is an atrocious crime, and this all because of those women who keep suppressing men in the name of feminism."

Feminism, a worldwide movement that started to establish, define and defend equal rights for women in all sections- economically, politically, and socially. India, being a patriarchal society gives a gender advantage to the men in the society thus, Indian feminists sought to fight against the culture-specific issue for women in India. Feminism itself is nothing but a simple movement that pursues equal rights for women (including transwomen) and against misogyny both external and internal. It states nowhere that women should get more wages than men, that women deserve more respect than men, that's pseudo-feminism.

Keep Reading Show less
wikimedia commons

Yakshi statue by Kanayi Kunjiraman at Malampuzha garden, Kerala

Kerala is a land of many good things. It has an abundance of nature, culture, art, and food. It is also a place of legend and myth, and is known for its popular folklore, the legend of Yakshi. This is not a popular tale outside the state, but it is common knowledge for travellers, especially those who fare through forests at night.

The legend of the yakshi is believed to be India's equivalent of the Romanian Dracula, except of course, the Yakshi is a female. Many Malayalis believe that the Yakshi wears a white saree and had long hair. She has a particular fragrance, which is believed to be the fragrance of the Indian devil-tree flowers. She seduces travellers with her beauty, and kills them brutally.

Keep Reading Show less
Pinterest

Ancient India not only made mentions of homosexuality but accepted it as well.


The LGBTQ+ acronym stands for Lesbian, Gay, Bisexual, Transgender, Queer, and others. In India LGBTQ+ community also include a specific social group, part religious cult, and part caste: the Hijras. They are culturally defined either as "neither men nor women" or as men who become women by adopting women's dress and behavior. Section 377 of the India Penal code that criminalized all sexual acts "against the order of nature" i.e. engaging in oral sex or anal sex along with other homosexual activities were against the law, ripping homosexual people off of their basic human rights. Thus, the Indian Supreme Court ruled a portion of Section 377 unconstitutional on 6th September 2018.

Keep reading... Show less