Friday March 22, 2019

Stem Cell Therapy to Treat Heart-Failure

For the study, the team induced experimental heart attacks in macaque monkeys

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heart-rate, inflammation
Higher levels of inflammation may in turn increase risk for heart diseases (IANS)

Stem cells may potentially be used as a “one-and-done” approach to restore function in people with heart-failure, a study has found.

Reported in the journal Nature Biotechnology, the study showed human stem cell treatment can possibly return the hearts’ functioning to better than 90 per cent of normal in macaque monkeys with heart attacks.

Heart-failure that causes nearly 10 million deaths worldwide, is a condition caused by lack of blood flow. The stem cells will help “form new muscle that will integrate into heart so it may pump vigorously again,” said Charles “Chuck” Murry, Professor at the University of Washington.

“Our findings show that human embryonic stem cell-derived cardiomyocytes can re-muscularise infarcts in macaque monkey hearts and, in doing so, reduce scar size and restore a significant amount of heart function. This should give hope to people with heart disease,” Murry said.

For the study, the team induced experimental heart attacks in macaque monkeys.

Two weeks later, the researchers took heart cells that they had grown from embryonic human embryonic stem cells and injected them into and around the young scar tissue. Each animal received roughly 750 million of these human embryonic stem cell-derived cardiomyocytes.

heart beat rate
Representational image. Pixabay

At four weeks after treatment, the ejection fraction in the treated animals rose to 49.7 per cent, about half-way back to normal, as compared to the untreated control animals, which remained unchanged at about 40 per cent.

MRI scans showed that new heart muscle had grown within what had been scar tissue in the treated hearts, while no new muscle was seen in the untreated animals.

Moreover, the human heart cells had also formed new muscle tissue in the damaged region. The new muscle tissue had replaced 10 per cent to 29 per cent of the scar tissue, integrated with the surrounding healthy tissue and developed into mature heart cells, the researchers said.

Also Read: Virtual Reality Tech Transforming Heart Treatments

Murry said that the research aims to develop a treatment that could be given to people shortly after a heart attack to prevent heart failure.

Because heart cells are long-lived there should be no need for additional treatments, he said. The transplanted stem cells would also be genetically altered to reduce the risk of immune rejection, which often complicates organ transplantation.

“What we hope to do is create a “one-and-done” treatment with frozen “off-the-shelf” cells that, like O-negative blood, can go into any recipient with only moderate immune suppression,” Murry said. (IANS)

Next Story

Smart Toilet Seats can Monitor Patients with Congestive Heart Failure

The toilet seats are equipped to measure the electrical and mechanical activity of the heart, and can monitor heart rate, blood pressure, blood oxygenation levels

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heart
The toilet seats would be purchased by hospitals and issued to heart failure patients after discharge, it added. Pixabay

Hospitals will soon be able to monitor patients with congestive heart failure in the comfort of their own homes, thanks to a new type of toilet-seats that can measure biometrics during “natural” processes.

The toilet seats are equipped to measure the electrical and mechanical activity of the heart, and can monitor heart rate, blood pressure, blood oxygenation levels, and the patient’s weight and stroke volume, which is the amount of blood pumped out of the heart at every beat.

Created by a team of researchers from the Rochester Institute of Technology in New York, the toilet seats will be brought through the US Food and Drug Administration (FDA) clearance process by the researchers’ company Heart Health Intelligence, the institute said in a statement on Wednesday.

heart
Algorithms in the seats will analyse the data, and with further development warn of deteriorating condition. Pixabay

The toilet seats would be purchased by hospitals and issued to heart failure patients after discharge, it added.

ALSO READ: Chinese Scientists Develop Robotic System for Medical Use

Algorithms in the seats will analyse the data, and with further development warn of deteriorating condition.

The system will pick up deteriorating conditions before the patients even realise they are symptomatic, said Nicholas Conn, a postdoctoral fellow at RIT and founder and CEO of Heart Health Intelligence. (IANS)