Tuesday December 10, 2019

Strength Training Can Help in Reducing Fatty Liver Disease, Says Study

More investigation is required in both animals and people to understand how liver metabolism is affected by strength training

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Obese mice performed strength training over a short time, the equivalent of which in humans would not be enough to change their body fat composition. Pixabay

Besides being beneficial for heart, strength training can also reduce accumulation of fat in liver and improve blood glucose regulation, says a study on mice.

The study, led by a team from the University of Campinas in Brazil, showed strength training can reduce fat stored in liver and improve blood glucose control in obese mice, even without overall loss of body weight.

The findings suggest strength training may be a fast and effective strategy for reducing the risk of fatty liver disease and diabetes in obese people.

“That these improvements in metabolism occurred over a short time even though the overall amount of body fat was unchanged, it suggests strength training can have positive effects on health and directly affect liver’s function and metabolism,” said Pereira de Moura from the varsity.

“It may be a more effective, non-drug and low-cost strategy for improving health,” she said.

During the research, published in the Journal of Endocrinology, the team investigated effects of strength-based exercise on liver fat accumulation, blood glucose regulation and markers of inflammation in obese mice.

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The study, led by a team from the University of Campinas in Brazil, showed strength training can reduce fat stored in liver and improve blood glucose control in obese mice, even without overall loss of body weight. Pixabay

Obese mice performed strength training over a short time, the equivalent of which in humans would not be enough to change their body fat composition.

After this short-term training, the mice had less fatty livers, reduced levels of inflammatory markers and their blood glucose regulation improved, despite no change in their overall body weight.

These health benefits would be even more effective if accompanied by reduction of body fat, she added.

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Based on these findings, obese individuals could be directed to increase their activities through strength training, but should always first consult their primary care physician.

More investigation is required in both animals and people to understand how liver metabolism is affected by strength training.

Obesity, a growing health epidemic globally, leads to inflammation in liver and impairs its ability to regulate blood glucose. It increases the risk of Type-2 diabetes and its associated complications, including nerve and kidney damage. (IANS)

Next Story

Researchers Discover Treatment for Obesity, Fatty Liver Disease

Goldblum predicts that in a few years we will hopefully be seeing several of these molecules in the pipeline for clinical studies on humans

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An overweight woman sits on a chair in Times Square in New York, May 8, 2012. (Representational image). VOA

Israeli researchers have discovered 27 new molecules, which may lead to a potential treatment for fatty liver disease, obesity and to heal wounds.

The findings, led by Professor Amiram Goldblum at the Hebrew University of Jerusalem, were made possible by a new algorithm, which chose the 27 molecules with the strongest therapeutic potential from a database of 1.56 million molecules.

These molecules, which are undergoing pharmaceutical evaluations to treat obesity and the incurable fatty liver disease, all activate a special protein called PPAR-delta (peroxisome proliferator-activated receptor delta).

PPAR-delta activation has the potential to increase physical endurance and trim waistlines by getting muscle cells to burn more fat, according to the study published in the Scientific Reports journal.

“With such a large group of highly active molecules, there is a high probability to find treatments for several common diseases. However, we should wait till all the experiments are done before we get our hopes up too high,” said Goldblum.

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Soon treatment for obesity, fatty liver disease . Pixabay

Future evaluations will hopefully include testing treatments for improved wound healing, and to prevent kidney toxicity in diabetics, the researchers said.

There is much pharmaceutical interest in Goldblum’s new molecules.

Integra Holdings, Hebrew University’s biotech company, determined that 21 of the 27 have the potential to reach pharmaceutical success, especially as a possible cure for fatty liver disease.

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In addition, Israel’s Heller Institute of Medical Research is currently testin g PPAR-delta’s physical endurance properties on mice.

Goldblum predicts that in a few years we will hopefully be seeing several of these molecules in the pipeline for clinical studies on humans. (IANS)