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Structure of brain can help find the causes behind epilepsy.
  • Latest research reveals that thickness and volume of brain can have an effect on our health
  • The differences can cause epilepsy
  • Apparently, there is more to epilepsy than realised

Thickness and volume differences in the grey matter of several brain regions could predict an increased risk of developing epilepsy — a neurological disorder characterised by seizures, finds a research led by a professor of Indian-origin.

Also Read : Stimulating Brain with Electricity may synchronise Brain waves and help improve short-term memory


Epilepsy affects 0.6-1.5 per cent of the global population, comprising many different syndromes and conditions, and defined by a tendency for seizures.

The findings showed reduced grey matter thickness in parts of the brain’s outer layer (cortex) and reduced volume in subcortical brain regions in all epilepsy groups when compared to the control group.


Connection between the grey matter and seizures. www.deccanchronicle.com

Reduced volume and thickness were associated with longer duration of epilepsy.

Adults with epilepsy exhibited lower volume in the right thalamus — a region which relays sensory and motor signals –and reduced thickness in the motor cortex, which controls the body’s movement.

These patterns were even present among people with idiopathic generalised epilepsies — a type of the disorder that are typically considered to be more benign if seizures are under control.

“We found differences in brain matter even in common epilepsies that are often considered to be comparatively benign,” said lead author, Sanjay Sisodiya, Professor at the University College London.

Also Read : Stress may trigger a form of Reflex Epilepsy and increase the risk of its Development

“We have identified a common neuroanatomical signature of epilepsy, across multiple epilepsy types. We found that structural changes are present in multiple brain regions, which informs our understanding of epilepsy as a network disorder,” added Christopher Whelan from the University of Southern California.


There is more to seizure than we actually realise.

For the study, published in the journal Brain, the team conducted MRI brain scans of 2,149 people with epilepsy, and compared with 1,727 healthy controls from across Europe, North and South America, Asia and Australia.

“Our findings suggest there’s more to epilepsy than we realise, and now we need to do more research to understand the causes of these differences,” Sisodiya said. IANS


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