Saturday August 18, 2018

Study- Fluid Drainage System in Brain Linked to Alzheimer

The study demonstrated that meningeal lymphatic vessels in the brain play an essential role in maintaining a healthy homeostasis in ageing brains and could be a new target for the treatment

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For the study, published in the journal Nature, the team engineered a hydrogel that can swell those lymphatic vessels.
For the study, published in the journal Nature, the team engineered a hydrogel that can swell those lymphatic vessels. (IANS)
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Scientists have identified a fluid drainage system in the brain that sheds light on the underlying mechanisms of brain ageing and age-related Alzheimer’s disease.

The study demonstrated that meningeal lymphatic vessels in the brain play an essential role in maintaining a healthy homeostasis in ageing brains and could be a new target for the treatment.

These vessels drain fluid from the central nervous system into the cervical lymph nodes and dysfunction of that drainage aggravates cognitive decline as well as Alzheimer’s disease pathology.

Moreover, when the healthy aged mice were treated with a molecule that increased meningeal lymphatic vessel size and fluid flow within those vessels, the mice showed improved performance on learning and memory tasks.

“As you age, the fluid movement in your brain slows, sometimes to a pace that’s half of what it was when you were younger,” said Jennifer Munson, Assistant Professor at the Virginia Polytechnic Institute and State University (Virginia Tech), in the US.

alzheimers
The study demonstrated that meningeal lymphatic vessels in the brain play an essential role in maintaining a healthy homeostasis in ageing brains. Pixabay

“We discovered that the proteins responsible for Alzheimer’s actually do get drained through these lymphatic vessels in the brain along with other cellular debris, so any decrease in flow is going to affect that protein build-up,” she added.

For the study, published in the journal Nature, the team engineered a hydrogel that can swell those lymphatic vessels.

As a result of the treatment, the bulk flow of fluid in the brain actually increased, and that seemed to have a positive effect on cognitive abilities.

Also Read: A Landmark Study Links Herpes 6 and 7 with Alzheimer’s Disease

Munson noted that older mice with normal, age-impaired cognitive abilities experienced the biggest gains in memory and learning from the treatment.

“Our results showed that someday this method could be used as a potential treatment to help alleviate the effects not only of Alzheimer’s, but also other age-related cognitive ailments,” Munson said. (IANS)

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A Landmark Study Links Herpes 6 and 7 with Alzheimer’s Disease

The findings also showed multiple points of overlap between virus-host interactions and genes associated with Alzheimer's risk

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For the study, published in the journal Nature, the team engineered a hydrogel that can swell those lymphatic vessels.
For the study, published in the journal Nature, the team engineered a hydrogel that can swell those lymphatic vessels. (IANS)

Scientists have found up to two times higher level of human herpes virus among people with Alzheimer’s disease, suggesting the potential role of the viruses in the development of the progressive brain disorder.

Herpes virus causes contagious sores, most often around the mouth or on the genitals.

The study found unusually increased level of human herpesvirus named human herpesvirus 6A (HHV-6A) and human herpesvirus 7 (HHV-7 ) in the brains of the people with Alzheimer’s than those without the disorder.

“The hypothesis that viruses play a part in brain disease is not new, but this is the first study to provide strong evidence,” said Richard J. Hodes, Director from the US National Institutes of Health.

“Our work identified specific biological networks that offer new testable hypotheses regarding the role of microbial defense and innate immune function in the pathophysiology of Alzheimer’s,” said Joel Dudley from the Institute for Next Generation Healthcare at the Icahn School of Medicine at Mount Sinai.

alzheimers
Patient of Alzheimer’s. Pixabay

The findings also showed multiple points of overlap between virus-host interactions and genes associated with Alzheimer’s risk. Multiple viruses impact the biology of Alzheimer’s disease across domains such as DNA, RNA and proteins.

“If it becomes evident that specific viral species directly contribute to an individual’s risk of developing Alzheimer’s or their rate of progression once diagnosed, then this would offer a new conceptual framework for understanding the emergence and evolution of Alzheimer’s at individual, as well as population, levels,” Dudley explained.

In the study, published in the journal Neuron, the team initially performed RNA sequencing on four brain regions in more than 600 samples of postmortem tissue from people with and without Alzheimer’s to quantify which genes were present in the brain, and whether any were associated with the onset and progression of Alzheimer’s.

Also Read: Parkinson’s Identified Gene to Combat Alzheimer’s

Using different computational approaches, the team uncovered a complex network of unexpected associations, linking specific viruses with different aspects of Alzheimer’s biology.

They examined the influence of each virus on specific genes and proteins in brain cells, and identified associations between specific viruses and amyloid plaques, neurofibrillary tangles, and clinical dementia severity.

Further, they incorporated 800, RNA sequencing samples and observed a persistent increase of HHV-6A and HHV-7 in samples from individuals with Alzheimer’s. (IANS)