Wednesday December 12, 2018

Study- Fluid Drainage System in Brain Linked to Alzheimer

The study demonstrated that meningeal lymphatic vessels in the brain play an essential role in maintaining a healthy homeostasis in ageing brains and could be a new target for the treatment

0
//
For the study, published in the journal Nature, the team engineered a hydrogel that can swell those lymphatic vessels.
For the study, published in the journal Nature, the team engineered a hydrogel that can swell those lymphatic vessels. (IANS)
Republish
Reprint

Scientists have identified a fluid drainage system in the brain that sheds light on the underlying mechanisms of brain ageing and age-related Alzheimer’s disease.

The study demonstrated that meningeal lymphatic vessels in the brain play an essential role in maintaining a healthy homeostasis in ageing brains and could be a new target for the treatment.

These vessels drain fluid from the central nervous system into the cervical lymph nodes and dysfunction of that drainage aggravates cognitive decline as well as Alzheimer’s disease pathology.

Moreover, when the healthy aged mice were treated with a molecule that increased meningeal lymphatic vessel size and fluid flow within those vessels, the mice showed improved performance on learning and memory tasks.

“As you age, the fluid movement in your brain slows, sometimes to a pace that’s half of what it was when you were younger,” said Jennifer Munson, Assistant Professor at the Virginia Polytechnic Institute and State University (Virginia Tech), in the US.

alzheimers
The study demonstrated that meningeal lymphatic vessels in the brain play an essential role in maintaining a healthy homeostasis in ageing brains. Pixabay

“We discovered that the proteins responsible for Alzheimer’s actually do get drained through these lymphatic vessels in the brain along with other cellular debris, so any decrease in flow is going to affect that protein build-up,” she added.

For the study, published in the journal Nature, the team engineered a hydrogel that can swell those lymphatic vessels.

As a result of the treatment, the bulk flow of fluid in the brain actually increased, and that seemed to have a positive effect on cognitive abilities.

Also Read: A Landmark Study Links Herpes 6 and 7 with Alzheimer’s Disease

Munson noted that older mice with normal, age-impaired cognitive abilities experienced the biggest gains in memory and learning from the treatment.

“Our results showed that someday this method could be used as a potential treatment to help alleviate the effects not only of Alzheimer’s, but also other age-related cognitive ailments,” Munson said. (IANS)

Click here for reuse options!
Copyright 2018 NewsGram

Next Story

Managing Cholesterol Might Help To Reduce Alzheimer’s Risk

These included several points within the CELF1/MTCH2/SPI1 region on chromosome 11 that previously had been linked to the immune system

0
alzheimer's, cholesterol
Can managing cholesterol reduce Alzheimer's risk? Read it out here. Pixabay

Managing cholesterol might help reduce Alzheimer’s risk, says researchers, including one of Indian-origin, who identified a genetic link between the progressive brain disorder and heart disease.

Examining DNA from more than 1.5 million people, the study showed that risk factors for heart disease such as elevated triglyceride and cholesterol levels (HDL, LDL, and total cholesterol) were genetically related to Alzheimer’s risk.

However, genes that contribute to other cardiovascular risk factors, like body mass index and Type-2 diabetes, did not seem to contribute to genetic risk for Alzheimer’s.

“The genes that influenced lipid metabolism were the ones that also were related to Alzheimer’s disease risk,” said Celeste M. Karch, Assistant Professor at the Washington University’s School of Medicine.

Thus, if the right genes and proteins could be targeted, it may be possible to lower the risk for Alzheimer’s disease in some people by managing their cholesterol and triglycerides, added Rahul S. Desikan, Assistant Professor at the UCSF.

For the study, published in the journal Acta Neuropathologica, the team identified points of DNA that increase the risk of cardiovascular disease and also heighten the risk for Alzheimer’s disease.

"The question for us now is not how to eliminate cholesterol from the brain, but about how to control cholesterol's role in Alzheimer's disease through the regulation of its interaction with amyloid-beta," Vendruscolo said.
In Alzheimer’s disease, patients start losing memory, Pixabay

The team looked at differences in the DNA of people with factors that contribute to heart disease or Alzheimer’s disease and identified 90 points across the genome that were associated with risk for both diseases.

Their analysis confirmed that six of the 90 regions had very strong effects on Alzheimer’s and heightened blood lipid levels, including several within genes that had not previously been linked to dementia risk.

These included several points within the CELF1/MTCH2/SPI1 region on chromosome 11 that previously had been linked to the immune system.

Also Read- Longer Exposure to Honking Traffic Makes You Obese

The researchers confirmed their findings in a large genetic study of healthy adults by showing that these same risk factors were more common in people with a family history of Alzheimer’s, even though they had not themselves developed dementia or other symptoms such as memory loss.

“These results imply that cardiovascular and Alzheimer’s pathology co-occur because they are linked genetically. That is, if you carry this handful of gene variants, you may be at risk not only for heart disease but also for Alzheimer’s,” Desikan said. (IANS)