Monday April 22, 2019

Study: Gout May Increase Dementia Risk in Elderly

Gout -- a very common condition -- is caused by deposits of crystals of a substance called uric acid (also known as urate) in the joints, which leads to inflammation

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The researchers believe that this type of low intensity sound therapy may benefit humans. (IANS)

Elderly people suffering from gout may have 17-20 per cent higher risk of dementia, suggests a new study by a team that includes an Indian-origin researcher.

Gout — a very common condition — is caused by deposits of crystals of a substance called uric acid (also known as urate) in the joints, which leads to inflammation.

Periods of time when patients are experiencing gout symptoms are called flares. Flares can be unpredictable and debilitating, developing over a few hours and causing severe pain in the joints.

“Our study found a considerable increased risk of dementia associated with gout in the elderly,” said co-author Jasvinder Singh, a Professor of Medicine and Epidemiology at the University of Alabama at Birmingham, in the US.

For the study, presented at the Annual European Congress of Rheumatology (EULAR 2018), the researchers included 1.23 million Medicare beneficiaries, of which 65,325 had incident dementia.

Dementia Risk to 50-year-olds With Raised Blood Pressure
Dementia Risk to 50-year-olds raises with Blood Pressure . Pixabay

In an analysis which was adjusted for various potential confounding variables including demographics, comorbidities and commonly used medications, the results showed that gout is independently associated with a significantly higher risk of dementia.

The association was larger in older age groups, females, black race, and people with higher medical comorbidity.

Subgroup analyses indicated that gout was associated with a significant 20-57 per cent increase in dementia in patients without key comorbidities; coronary artery disease (CAD), hyperlipidemia, cardiovascular disease, diabetes or hypertension.

Also Read: Study: Dementia Risk to 50-year-olds With Raised Blood Pressure

However, this was not the case in patients with each of these comorbidities, except in patients with CAD, the researchers said.

Guidelines for the treatment of gout recommend lowering uric acid levels, although maintaining too low levels is a concern because uric acid is thought to protect the brain, they added.

“Further study is needed to explore these relationships and understand the pathogenic pathways involved in this increased risk,” Singh noted. (IANS)

Next Story

Late Onset of Menstruation May Spike up Dementia Risk, Says Study

For the study, the researchers involved 6,137 women among which 42 per cent later developed dementia

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Representational Image- dementia, Pixabay

Women whose menstruation starts later and those who enter menopause early may have a greater risk of developing dementia, say researchers.

The findings showed that women who had their first menstrual cycle at age 16 or older had a 23 per cent greater risk of dementia than women who had their first menstrual cycle at age 13.

Women who went through natural menopause before age 47 had a 19 per cent greater risk of dementia than women who went through menopause at age 47 or older.

In addition, women who had hysterectomy — surgery to remove all or part of the uterus — had an eight per cent greater risk of dementia than those who did not, according to the study, published in the journal Neurology.

1 in 6 people over the age of 80 have dementia. Pixabay
1 in 6 people over the age of 80 have dementia. Pixabay

“Oestrogen levels can go up and down throughout a woman’s lifetime. Our results show that less exposure to oestrogen over the course of a lifetime is linked to an increased risk of dementia,” said Paola Gilsanz, Researcher at Kaiser Permanente – a US-based healthcare company.

For the study, the researchers involved 6,137 women among which 42 per cent later developed dementia.

Also Read- Food Insecurity In New York, Indian-Americans Work To Raise Awareness

“Since women are 50 per cent more likely to develop dementia over their lifetimes than men, it’s important to study any risk factors that are specific to women that could eventually lead us to potential points of intervention,” Gilsanz suggested. (IANS)