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Researchers have made an exciting leap forward in understanding how skin heals, which could lead to drug treatments to vastly improve wound healing.
According to the study, published in the journal Cell Stem Cell, people who suffer severe burns or extensive skin injuries are often left to live with the skin that feels chronically tight and itchy.
“We identified a specific population of progenitor cells that reside within the dermis, the deep connective tissue of the skin,” said lead author Jeff Biernaskie from the University of Calgary in Canada.
Progenitor cells are unique in that they are able to undergo cell division and generate many new cells to either maintain or repair tissues.
“The following injury, these dermal progenitors become activated, proliferate and then migrate into the wound where they generate nearly all of the new tissue that will fill the wound, both scar, and regenerated tissue,” Biernaskie explained.
This study offers new knowledge on why certain dermal cells are able to regenerate new skin, rather than disfiguring scar tissue.
Using cutting-edge genomics techniques to profile thousands of individual cells at different times after injury, the research team compared scar-forming versus regenerative zones within skin wounds.
The researchers found that although these cells come from the same cellular origin, different micro-environments within the wound activate entirely different sets of genes.
“Meaning, the signals found within ‘regenerative zones’ of the wound promote re-activation of genes that are typically engaged during skin development,” Biernaskie said.
“Whereas in scar-forming zones these pro-regenerative programs are absent or suppressed and scar-forming programs dominate,” he added.
Working with these findings, the researchers then showed it’s possible to modify the genetic programs that govern skin regeneration.
“What we’ve shown is that you can alter the wound environment with drugs, or modify the genetics of these progenitor cells directly, and both are sufficient to change their behavior during wound healing,” the researchers said.
“And that can have really quite impressive effects on healing that includes regeneration of new hair follicles, glands, and fat within the wounded skin,” they added.
Also Read: New Study Predicts Extreme Hot Areas in U.S.
This research offers critical insights into the molecular signals that drive scar formation during wound healing and it identifies a number of genetic signals that are able to overcome fibrosis and promote true regeneration of adult skin.
“Our hope is to develop a cocktail of drugs that we could safely administer in humans and animals to entirely prevent genetic programs that initiate scar formation in order to greatly improve the quality of skin healing,” the authors wrote. (IANS)
By Prerana Agarwal Saxena
Choose locally sourced material to uplift artisans
Sustainable can be luxurious too, incorporate some native flavour into the decor and theme. With the use of locally sourced materials and local artisans coming into play, the wedding instantly becomes sustainable. Include the work of local vendors ensure minimal packaging requirements, thus saving on unnecessary plastic and lamination. It also decreases the need for transporting elements from other cities and hence lowers the carbon footprint. For instance, at one of our weddings, we made use of sand art for a setup in Jodhpur. This helped promote local work while also being environmentally friendly with zero wastage of other materials. In another instance from Rajasthan, the traditional glass-blown technique was used to build decor items while giving a cultural touch to the destination wedding.
Say yes to recycling
One should be mindful and avoid the use of plastic and other non-recyclable materials in decor wherever possible. It can be a small step such as making a conscious switch from plastic water bottles to copper jugs or glass bottles. Also use artificial floral decor thus minimising the wastage produced from real flowers. This recyclable decor is then donated to various NGOs, further ensuring sustainable use of resources. Such steps, however small they might be, keep the environment free from the release of any additional carbon footprint.
Make use of fabric as it enhances the elegance of the wedding while being sustainable. Include vibrant colours apt to the theme of the wedding and bring in bright sprightliness with breathable fabrics. Ensure to include LED lights for lighting. They can be incorporated as string lights or be used on passageways with innovative decor items. They also help conserve energy and bring in soulful energy for nighttime decor. Choose virtual invitations, keeping up with the digital times. Make a conscious choice of plated dinner menus rather than a buffet as they allow less wastage of food and ensure enough food for guests in attendance.
Include Sustainable Gifting
Gift sustainable wedding favours -- gifts that grow. Offering a plant or a succulent, is a great idea. One can also gift recycled organic fabrics and cutlery or zero-waste kitchen and bathroom essentials to use in their homes as some distinct gifting options.
Gift sustainable wedding favours -- gifts that grow. | Photo by Kira auf der Heide on Unsplash
By applying the values of sustainability, you can reduce the energy consumed and the resources used as much as possible. Go ahead and have a luxurious zero-waste wedding and navigate into the world of green living! (IANS/ MBI)
The health department officials also said that as the state has almost exhausted its quota of vaccines, there would not be any vaccines on Monday. Regular vaccination will resume after the vaccine supplies arrive from New Delhi, officials said. The state health department had expected to vaccinate 15 lakh people on Sunday in 18,824 centres spread across primary health centres, anganwadis, noon meal centres, government hospitals, schools and some auditoriums.
Of the 16,43,879 people who were inoculated, a total of 10,85,097 received their first dose and 5,58,782 their second dose of vaccine, the statement said, A total of 9,66,568 people in the age group of 18-44 were vaccinated on Sunday and vaccines were administered on 5,02,578 people aged between 45- 59 in the mega vaccine camps.
State health minister Ma Subramanian, who inaugurated the vaccination at Pollachi, also visited the centres in six districts -- Coimbatore, Erode, Namakkal, Tiruppur, Dharmapuri and Salem. The state government, according to the health minister, is to receive the next allotment of vaccines on September 21. Minister while speaking to IANS said, "We will be receiving the next allotment of vaccines on September 21 itself and we will resume vaccinations immediately. The state has already touched one crore vaccine-mark in the month of September till date." (IANS/MBI)
Keywords: COVID, vaccine, vaccination camp, Tamil Nadu, India, vaccinated, mega camp
We don't see a future where classic red lips go out of fashion. The right way to achieve this celebrity look is to focus on accentuating your lips and keeping the rest of the face minimal. Give your lips a good scrub to plump them, moisturize and follow it up with a red lip liner to define the shape of your lips. Now go on with the perfect shade of red and finish your look with a slick of eyeliner, minimal concealer, and foundation.
We don't see a future where classic red lips go out of fashion. | Photo by Ina Garbé on Unsplash
Deepika Padukon is the perfect example of a no-makeup look. This natural beauty does a wonderful job of achieving the minimal soft look by softly cover any dark spots or blemishes and highlighting features she's most proud of. To achieve this start with concealer and use small dots to brighten your darker areas like under eye, corner of the nose or upper lip, and any visible spots, and set it up with loose powder. Apply a soft pink lipstick, light blush, and mascara.
Deepika Padukon is the perfect example of a no-makeup look | Wikimedia Commons
This look shouts pink. When it comes to rosy looks, Janhavi Kapoor does a phenomenal job. Everyone should try a rosy look once in a while. As we are focusing on only one shade, this look is pretty easy to achieve. Bring out your favourite pink lipstick, favourite pink blush, and a matching shade of eye shadow. Start with the base - concealer, and foundation and set it up with loose powder. Follow it up with eyeshadow, lipstick, and blush. Remember to draw a line by not using any pink mascara, eyeliner, or a bold shade of lipstick, as this is meant to be soft on the eyes.
When it comes to rosy looks, Janhavi Kapoor does a phenomenal job. | Wikimedia Commons
The glass skin makeup is inspired by Korean skincare. This look is slightly complex with an equal focus on skin before makeup, so slather on those moisturizing serums and creams to prep your skin first. Start with a highlighting primer, keep your foundation and concealer minimal to avoid looking cakey. Follow it up with soft blush & nude lips and lots and lots of highlighter. Use the highlighter on the main points of your face, like upper cheekbones, the centre of the forehead, the tip of the nose, cupid bone, and chin. If you are feeling a bit extra, don't hesitate to put some on your shoulders and collar bones. This celebrity makeup look makes your skin glow without the need for a spotlight.
The glass skin makeup is inspired by Korean skincare. | Photo by 邱 严 on Unsplash
Put a zing to your party look with the pop of funky colour. This look is meant to get you in the mood of partying all night. This works with your eye makeup while keeping the rest of the face minimal. Start with the base - concealer, apply a bit extra on your eyelids to make the colour pop. Don't mind going the extra mile and colour blocking your eyes with complementary colours on eyelids and under the eye. Apply nude lipstick and a soft blush to balance your look.
This look is meant to get you in the mood of partying all night. | Pixabay
(Article originally published by N. Lothungbeni Humtsoe) (IANS/ MBI)
Keywords: Celebrity, makeup, Deepika, Jhanavi, Korean, Red Lipstick, Glass Makeup, Pop makeup