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There is a possibility that targeting the enzyme MAPK4 in human prostate cancer might provide a novel therapeutic strategy for the disease, said researchers. The study indicates that the enzyme MAPK4 concertedly activates androgen receptor (AR) and AKT, molecules at the core of two cellular signaling pathways known to promote prostate cancer growth and resistance to standard therapy.
“Our findings suggest the possibility that regulating MAPK4 activity could result in a novel therapeutic approach for prostate cancer,” said researcher Feng Yang, Assistant Professor at Baylor College of Medicine in the US. “We are interested in finding an inhibitor of MAPK4 activity that could help better treat prostate cancer and other types of cancers in the future,” Yang added.
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In their previous study, the researchers discovered that MAPK4 could trigger the AKT pathway, not only in prostate cancer but in other cancers as well, such as lung and colon cancers. In the current study published in theJournal of Clinical Investigation’, the researchers found that MAPK4 also activates the AR signaling pathway by enhancing the production and stabilization of GATA2, a factor that is crucial for the synthesis and activation of AR.
Further experiments showed that MAPK4 triggered the concerted activation of both AR and AKT pathways by independent mechanisms, and this promoted prostate cancer growth and resistance to castration therapy, a standard medical treatment for advanced/metastatic prostate cancer.
Importantly, genetically knocking down MAPK4 reduced the activation of both AR and AKT pathways and inhibited the growth, including castration-resistant growth, of prostate cancer in animal models. The researchers anticipate that knocking down MAPK4 could also reduce the growth of other cancer types in which MAPK4 is involved. (IANS)
Probiotics may significantly improve the symptoms of pregnancy-related nausea, vomiting and constipation, finds a new study.
The study, published in the journal Nutrients, showed that nausea hours (the number of hours participants felt nauseous) were reduced by 16 per cent, and the number of times they vomited was reduced by 33 per cent.
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Probiotic intake also significantly improved symptoms related to the quality of life, such as fatigue, poor appetite and difficulty maintaining normal social activities, as scored by questionnaires.
"The cause of nausea and vomiting during pregnancy is unknown to this date. Various theories have been proposed, but none of them is conclusive," said lead author Albert T. Liu from the University of California, Davis.
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"Nausea, vomiting and constipation during pregnancy can significantly diminish the quality of patients' lives. Once nausea and vomiting during pregnancy progress, they can become difficult to control, and sometimes the patient even needs to be hospitalized," Liu added.
For the study, the team involved a small yet significant number of participants who took a probiotic capsule twice a day for six days and then took two days off. They then repeated the cycle.
The team found that probiotics were also found to reduce constipation significantly.Unsplash
The probiotics were available over-the-counter and mainly contained Lactobacillus., a type of good bacteria. Each capsule contained approximately 10 billion live cultures at the time of manufacture.
Participants kept 17 daily observations of their symptoms during the duration of the study, for a total of 535 observations for the researchers to statistically assess.
The team found that probiotics were also found to reduce constipation significantly.
Another finding was that vitamin E levels increased after taking probiotics. Higher levels of vitamin E were associated with low vomiting scores. (IANS/SP)
(Keywords : probiotics, pregnancy, nausea, vomiting, nutrients, symptoms, fatigue, appetite, constipation, vitamin.)
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By Olivia Sarkar
If the year 2020 appeared bleak for the world, the year 2021 served as a frightening reminder that it wasn't so much about the year as it was about the times we've come to live in. Every domain and industry has experienced seismic shifts, both for the better and for the bad. However, just a few fields have seen such a huge paradigm shift as online dating throughout the course of 2021.
It becomes critical to document and analyse the important observations in the year 2021's dating trends in order to determine where online dating stands and where it is headed. This is where a poll conducted by one of India's popular dating apps, QuackQuack, comes in handy. "The pandemic has undoubtedly thrown a few curveballs towards folks wanting to date," remarked Mr. Ravi Mittal, Founder and CEO of QuackQuack, in response to the survey report. Males and females, in my opinion, are fast coming to terms with a new universe of online dating every day, adopting more self-paced and healthier forms of dating, a growing process that will soon become the standard."
The key takeaways from the survey can be best summarized as below:
- Vaccination is a must: An overwhelming 8 out of 10 persons in the survey's sample size expressed support for mandatory vaccination as a prerequisite to a date. A considerable 65 per cent and 75 per cent of people in the 18-20 and 21-30 age categories, respectively, agreed on the same thing. The need of a double jab was consistently emphasized across the country's top cities and tier 2 cities, with 75 per cent and 70 per cent of the sample size in each believing that the first step toward a safe date would have to be complete immunization of the other.
An overwhelming 8 out of 10 persons in the survey's sample size expressed support for mandatory vaccination as a prerequisite to a date. | Photo by CDC on Unsplash
- Dating with a purpose: The poll revealed that, because of the Covid procedures in place, people have had little motivation to walk outside, leading them to think on the nature of the dates they've discovered on the dating app rather than searching for matches in a desperate manner. The survey found that 47 per cent of women and 35 per cent of men agreed with this behavioral change, and that the act of reflection and introspection allowed them to have healthier relationships than before.
The difference in deliberate dating trends between people who live in cities and those who live in rural or semi-urban settings was quite similar. While roughly 37 per cent of urban teenagers believed their dating experience had taken an intentional turn, 39 per cent of rural or semi-urban teenagers felt the same way.
The difference in deliberate dating trends between people who live in cities and those who live in rural or semi-urban settings was quite similar. | Photo by René Ranisch on Unsplash
- Location is pivotal: According to the survey, a whopping 58 per cent and 56 per cent of people between the ages of 18 and 20 and 21 and 30 preferred hooking up with someone from a different place to broaden their search for a potential spouse. This trend proved to be more prevalent among women, as 58 per cent of them were comfortable dating partners from foreign countries, compared to only 50 per cent of men. Further study into a demographic analysis of the sampled data found that 46 per cent of those living in major metro cities preferred dating outside of their home location, while 57 per cent of those living in smaller cities and towns favored the same.
According to the survey, a whopping 58 per cent and 56 per cent of people between the ages of 18 and 20 and 21 and 30 preferred hooking up with someone from a different place to broaden their search for a potential spouse. | Pixabay
- Video calling versus meeting in person: Due to the ongoing Covid problem across the country, a large majority of 56 per cent of 18 to 20-year-olds preferred having their first date on a virtual medium and were risk-averse, according to the survey. On the other hand, 43 per cent of persons aged 30 and up, who adhere to a more traditional approach, decided to meet in person while taking all essential safety steps.
43 per cent of persons aged 30 and up, who adhere to a more traditional approach, decided to meet in person while taking all essential safety steps. | Photo by Matt W Newman on Unsplash
According to the survey, a vast majority of 56 per cent of 18 to 20-year-olds preferred having their first date on a virtual medium and were risk-averse due to the ongoing Covid crisis across the country. In contrast, 43 per cent of people aged 30 and up who prefer a more traditional approach preferred to meet in person while following all necessary safety precautions according to the survey. (IANS/ MBI)
(Keywords: meeting, Video calling, Location, Vaccination, dating trends, 2021, Online Dating)
Today marks the birth anniversary of Josh Malihabadi, who popularly known as ‘Shayar-e-Inquilab’ or ‘Poet of the Revolution’.
An Indian-born poet
Josh Malihabadi, born as Shabbir Hasan Khan, was born in Malihabad, a town in Lucknow district of Uttar Pradesh, British India. At first, he received his education in Arabic, Persian, Urdu, and English at his home only, and later on Malihabadi studied at St. Peter's College in Agra and passed his Senior Cambridge examination in the year 1914. Thereafter, he studied Arabic and Persian languages, and in the year 1918, Malihabadi spent six months at Tagore’s University in Shantiniketan, West Bengal.
Josh Malihabadi (centre) along with Pablo Neruda (left) and Young Ali Sardar Jafri (right). Photo by Flickr
Family of poets
Interestingly, Malihabadi’s family produced many poets; be it his great-grandfather, Nawab Faqeer Muhammad Khan ‘Goya', grandfather Nawab Muhammad Ahmad Khan, paternal uncle Ameer Ahmad Khan, and even his father Basheer Ahmad Khan. Each one of them had numerous works including poetry collections, translations, and essays published in their name. Perhaps, this was the reason why Josh Malihabadi is considered as one of the finest poets of the British India era.
Outset of writing career
Malihabadi's career in the field of writing and poetry began when in 1925, he started to supervise translation work at Osmania University in the princely state of Hyderabad. After sometime, he founded the magazine ‘Kaleem’ (meaning, "speaker" in Urdu), in which he wrote articles in favor of independence from the British rule in India. In fact, his poem ‘Hussain aur Inquilab’ won him the title of ‘Shayar-e-Inquilab’ (Poet of the Revolution). Moreover, over the passage of time, Malihabadi became more involved in the freedom struggle and even became close to Pandit Jawaharlal Nehru.
Over the passage of time, Malihabadi became more involved in the freedom struggle and even became close to Pandit Jawaharlal Nehru.Photo by Flickr
Migration to Pakistan
After the British rule ended in India, in the year 1956, Malihabadi migrated to Pakistan because of his concern regarding the future of himself as a poet and Urdu language. This decision of Malihabadi moving to Pakistan was highly opposed by Pandit Jawaharlal Nehru. After moving to Pakistan, Malihabadi was consistently involved in the process of writing poetry and holding literary conferences. In fact, a noted scholar and literary critic, Pervez Hoodbhoy, quoted once about Malihabadi’s writing. He said, "Poetry flowed from Josh's pen like water from a bubbling spring."
Today, on the 123rd birth anniversary of Josh Malihabadi, let us remember his contribution in the freedom struggle of India and in the field of poetry!
(Keywords: India, Pakistan, Josh Malihabadi, Birth Anniversary, Jawaharlal Nehru, Literature, Writing, Poetry)