Never miss a story

Get subscribed to our newsletter


×
Regulating MAPK4 activity could result in a novel therapeutic approach. Pixabay

There is a possibility that targeting the enzyme MAPK4 in human prostate cancer might provide a novel therapeutic strategy for the disease, said researchers. The study indicates that the enzyme MAPK4 concertedly activates androgen receptor (AR) and AKT, molecules at the core of two cellular signaling pathways known to promote prostate cancer growth and resistance to standard therapy.

“Our findings suggest the possibility that regulating MAPK4 activity could result in a novel therapeutic approach for prostate cancer,” said researcher Feng Yang, Assistant Professor at Baylor College of Medicine in the US. “We are interested in finding an inhibitor of MAPK4 activity that could help better treat prostate cancer and other types of cancers in the future,” Yang added.


Follow NewsGram on Twitter to stay updated about the World news.

In their previous study, the researchers discovered that MAPK4 could trigger the AKT pathway, not only in prostate cancer but in other cancers as well, such as lung and colon cancers. In the current study published in theJournal of Clinical Investigation’, the researchers found that MAPK4 also activates the AR signaling pathway by enhancing the production and stabilization of GATA2, a factor that is crucial for the synthesis and activation of AR.

ALSO READ: Prostate Cancer Can Be Detected By AI Through Urine

Further experiments showed that MAPK4 triggered the concerted activation of both AR and AKT pathways by independent mechanisms, and this promoted prostate cancer growth and resistance to castration therapy, a standard medical treatment for advanced/metastatic prostate cancer.

Importantly, genetically knocking down MAPK4 reduced the activation of both AR and AKT pathways and inhibited the growth, including castration-resistant growth, of prostate cancer in animal models. The researchers anticipate that knocking down MAPK4 could also reduce the growth of other cancer types in which MAPK4 is involved. (IANS)


Popular

IANS

South Korea remained the No. 2 supplier of popular content to Netflix in the fourth quarter of last year.

South Korea remained the No. 2 supplier of popular content to Netflix in the fourth quarter of last year, US online media have reported. According to What's On Netflix, a private online site that provides information on Netflix content, on Wednesday (US time), South Korean-made shows accounted for 11.8 per cent of the top 10 films and TV series in the final three months of 2021.

ALSO READ: Lessons Learnt From Squid Game

Keep Reading Show less
IANS

There has been a significant growth in adoption as well as deepening of digital payments across the country.

There has been a significant growth in adoption as well as deepening of digital payments across the country, showed the Reserve Bank of India - Digital Payments Index (RBI-DPI) on Wednesday. Accordingly, the index reading for September 2021 rose to 304.06 (index value) from 270.59 in March 2021. "The RBI-DPI Index continues to demonstrate significant growth in adoption and deepening of digital payments across the country," the RBI said in a statement.

Starting from March 2018, the index stood at 153.47 in March 2019, 173.49 in September 2019. This improved to 207.84 in March 2020, 217.74 in September 2020 and further increased to 270.59 in March 2021. Earlier, the RBI had announced construction of the composite index with March 2018 as a base to capture the extent of digitisation of payments across the country.

Starting from March 2018, the index stood at 153.47 in March 2019, 173.49 in September 2019. | Wikimedia Commons

Keep Reading Show less

HUH Token is the altcoin trailblazer that launched a little over a month ago.

After an embarrassingly slow start to the crypto new year, the tides of the crypto machine are starting to change and with it, the investors of Avalanche and HUH Token have received some rather spectacular rewards.

The cryptocurrency market this week saw value increases of over 20% and that’s enough to signal to any crypto investor that things are going better in the crypto sphere than last weeks value increase percentages, which, for the most part, were on a downtrend.

Keep reading... Show less