Saturday September 22, 2018

TB Vaccine May Help to Control Type-1 Diabetes, Says Study

Type - 1 diabetes is a chronic condition in which the pancreas produce little or no insulin

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The study included 4,697 mothers and 4,832 children. (IANS)
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A vaccine primarily used for treating tuberculosis (TB) may be effective in reducing high blood sugar among people with Type – 1 diabetes, results from a clinical trial has revealed.

Type – 1 diabetes is a chronic condition in which the pancreas produce little or no insulin.

The findings showed that, three years after receiving two administrations of the Bacillus Calmette-Guerin (BCG) vaccine four weeks apart, people with longstanding Type-1 diabetes showed an improvement in HbA1c — Aglycated haemoglobin — measured to test the overall sugar levels to near normal levels.

“This is clinical validation of the potential to stably lower blood sugars to near normal levels with a safe vaccine, even in patients with longstanding disease,” said Denise Faustman, director of the Massachusetts General Hospital Immunobiology Laboratory, US.

Representational image.
Representational image. Pixabay

The study, published in the journal npj Vaccine, also reported that the effects of BCG vaccine on blood sugar control appear to depend on a totally novel metabolic mechanism that increases cellular consumption of glucose.

The team analysed data from 282 human study participants — 52 with Type-1 diabetes who participated in the BCG clinical trials and 230 who contributed blood samples for mechanistic studies.

The results showed that the HbA1c levels of those receiving BCG had dropped by more than 10 per cent in three years after treatment and by more than 18 per cent in four years.

Also Read: Study: Plant-based Diets Can Help Diabetes Patients

The study showed that BCG vaccination induces epigenetic reprogramming at the chromatin architecture level and functional alterations indicative of a permanent change in immunity.

Thus, the clinical effects and the proposed mechanism add to the emerging consensus that the BCG vaccine can have a lasting and valuable impact on the immune system, the researchers said. (IANS)

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Kids of Mothers With Type-1 Diabetes at Risk of Being Overweight

Children of mothers with Type-1 diabetes had a significantly higher body mass index than children from mothers without diabetes

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The findings, published in the journal Diabetologia, were based on data from nearly 2,800 children with a first-degree relative with Type-1 diabetes.
The findings, published in the journal Diabetologia, were based on data from nearly 2,800 children with a first-degree relative with Type-1 diabetes. Pixabay

Children of mothers with Type-1 diabetes are at significantly higher risk of being overweight and of exhibiting insulin resistance, new research has found.

“Our study shows that children of mothers with Type-1 diabetes are not only at significantly higher risk of having the condition itself, but are also at greater risk of being overweight and developing insulin resistance,” said one of the researchers Anette-Gabriele Ziegler from Helmholtz Zentrum Munchen – German Research Center for Environmental Health, Munich-Neuherberg.

“We would therefore advise that paediatricians should bear this correlation in mind, so that they can react on early warning signs in such children,” Ziegler added.

The findings, published in the journal Diabetologia, were based on data from nearly 2,800 children with a first-degree relative with Type-1 diabetes.

Representational image.
Representational image. Pixabay

“Their metabolic status and body weight were tracked up to the age of 18,” said lead author Anitha Pitchika from Helmholtz Zentrum Munchen.

Type-1 diabetes is the most common metabolic disorder in childhood. It was already known that children of parents with Type-1 diabetes are at much higher risk of developing the disease than the rest of the population.

Also Read: Diabetes? Living Near Woods May Cut Risk of Elevated Blood Sugar

“Moreover, there were also sporadic indications from previous studies that children of mothers with Type-1 diabetes are also at increased risk of having metabolic syndrome, as the intermittent high blood glucose levels in the uterus appear to have long-term effects on the child’s metabolism and body weight,” explained Andreas Beyerlein from Helmholtz Zentrum Munchen.

In this study, the researchers investigated this hypothesis with a large dataset and found that children of mothers with Type-1 diabetes had a significantly higher body mass index than children from mothers without diabetes. (IANS)