Thursday August 22, 2019

TCD Collaborates with Tata Memorial Centre to Bring Saliva-Based Test for Screening Oral Cancer to India

The core objective of this research project is to detect presence of mutations in a non-invasive method from the tumour in patients with oral cancer

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Medicare covers more than 60 million seniors and people with disabilities. Pixabay

With an aim to bring a saliva-based test for screening oral cancer to India, the Tata Centre for Development (TCD) at Chicago University in the US on Wednesday announced collaboration with the Tata Memorial Centre (TMC) in Mumbai.

The test could be used for patients to detect tumour DNA from mouth cancers. The core objective of this research project is to detect presence of mutations in a non-invasive method from the tumour in patients with oral cancer. ­

Currently, observational clinical trial is going on throughout India to develop the test, the Tata Centre for Development said in a statement.

This collaboration is expected to augment the efforts towards collecting tumour tissue and matched saliva from patients with oral cancer.

TCD, Saliva, Cancer
With an aim to bring a saliva-based test for screening oral cancer to India, the Tata Centre for Development (TCD) at Chicago University in the US on Wednesday announced collaboration. Pixabay

“Our collaboration with the Tata Memorial Centre will help us in developing the assay and conducting the trial,” said Nishant Agrawal, Professor at University of Chicago Medical Center.

Oral cancer ranks among the top three types of cancer in India. It is also the leading cancer among men and the fifth most frequently occurring cancer in women.

India, reportedly, contributes nearly 60 per cent to the oral cancer burden worldwide, and the number of cases is expected to double by 2030. Unfortunately, 60-80 per cent of oral cancers are diagnosed at advanced stages when survival is well below 50 per cent.

“With recent advances in sequencing technology, we have been able to demonstrate that tumour DNA can be detected in saliva of patients. It is an easily accessible, non-invasive liquid biopsy method,” Agrawal said.

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Evidence suggests that if oral cancer is diagnosed early and treated as localised tumours, the five-year survival rate would significantly improve. The five-year survival rate for stage III or IV cancer is between 20 and 40 per cent as opposed to 70-90 per cent for stage I or II cancer.

“The research holds promise for both the patients and the doctors because it gives them an opportunity to address pre-cancerous lesions and early detection of invasive cancer and treat it with simple interventions,” said Rajendra Badwe, Director at Tata Memorial Centre in Mumbai. (IANS)

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Women with Obstructive Sleep Apnea (OSA) at Elevated Risk of Getting Cancer

It's reasonable to assume that sleep apnea is a risk factor for cancer or that both conditions have common risk factors, such as overweight

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Women, OSA, Cancer
The study, published in the European Respiratory Journal, is based on analyses of registry data, collected in the European database ESADA, on a total of some 20,000 adult patients with obstructive sleep apnea (OSA). Pixabay

Women with obstructive sleep apnea (OSA) appear to be at an elevated risk of getting cancer than men with the condition, warn researchers.

The study, published in the European Respiratory Journal, is based on analyses of registry data, collected in the European database ESADA, on a total of some 20,000 adult patients with obstructive sleep apnea (OSA). About 2 per cent of them also had a cancer diagnosis.

“It’s reasonable to assume that sleep apnea is a risk factor for cancer or that both conditions have common risk factors, such as overweight. On the other hand, it is less likely that cancer leads to sleep apnea,” said Ludger Grote, Professor at the University of Gothenburg in Sweden.

According to the researchers, advanced age was associated with elevated cancer risk, but adjusting the data for age, gender, body mass index (BMI), smoking and alcohol consumption nevertheless showed a possible link between intermittent hypoxia at night and higher cancer prevalence.

Women, OSA, Cancer
Women with obstructive sleep apnea (OSA) appear to be at an elevated risk of getting cancer than men with the condition, warn researchers. Pixabay

The connection applied mainly to women and was weaker in men.

“Our results indicate a cancer risk that’s elevated two- to three-fold among women with pronounced sleep apnea,” Grote said.

The condition of sleep apnea is well known to the general public and associated with snoring, daytime fatigue, and elevated risk of cardiovascular disease, especially in men, said the study.

This research paves the way for a new view — that sleep apnea may possibly be connected with increased cancer risk, especially in women.

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“Above all, the focus has been on the connection with one form of cancer: malignant melanoma. Cancer of the breast or womb may now become a new area. There may be a combined effect of female sex hormones and stress activation, induced by nocturnal hypoxia in sleep apnea, that can trigger cancer development or a weakening of the body’s immune system,” Grote concluded. (IANS)