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Indian Institute of Technology Guwahati (IIT-G) on Tuesday said its researchers have developed a low-cost membrane technology to produce psychoactive drugs and anti-aging compounds from a wide range of agricultural resources.
A psychoactive drug is a chemical substance that changes nervous system function and results in alterations in perception, mood, consciousness, cognition, or behavior.
The health-related benefits of psychoactive drugs (caffeine) and anti-aging compounds (i,avonoids) attributed to stimulating detoxification of enzyme activity and inhibition of cell invasion and angiogenesis.
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Because of medicinal applications, i.e, avonoid components have gained popularity as ingredients in the pharmaceutical industry.
These are also found in smaller amounts in bamboo leaves, grapes, apples, and other natural sources.
The researchers used agricultural resources like Camellia Sinensis, citrus fruits, and peels especially orange peels, berries, ginkgo Biloba, parsley, pulses, tea, sea buckthorn, and onions.
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“The developed technology is exclusively pore/particle size-based pressure-driven membrane separation process,” Mihir Kumar Purkait, Head, Centre for the Environment, and Professor, Department of Chemical Engineering, IIT Guwahati, said in a statement.
The water extracts of the above-mentioned plants/fruits/leaves at optimum operating conditions are passed through specially made cascade membrane units fabricated with appropriate molecular weight cut off (MWCO) membranes capable of separating targeted flavonoids selectively.
According to the Institute, permeate and retentive part from the appropriate membrane unit is then fridge dried to get the powdered product.
“We have synthesized stimuli-responsive smart membrane for the selective separation and purification of the targeted compound from the mixture of plants or leaves or fruits extract in simple water,” Purkait said.
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The commercially available techniques are using various costly organic solvents like Chloroform, Acetone, Acetonitrile, etc.
As a result, the price of these important pharmaceutical raw materials is quite high that ultimately increases the price of the antioxidant.
The technology developed by Professor Purkait doesn’t require any costly organic solvents and uses only water.
Want to read more in Hindi? Checkout: जानिए ट्रोल्स को लेकर क्या कहना है कॉमेडी किंग कपिल शर्मा का
Hence, the cost of the process and price of pharmaceuticals thereon is much cheaper than that of the existing solvent-based separation technique.
The patented membrane-based green technology has enormous scope to replace existing costly organic solvent-based techniques and can be used for the continuation mode of operation on an industrial scale.
Implementation of the said technology will also create job opportunities in the agriculture sector of the country, the Institute said. (IANS)
Scientists temporarily attached a pig's kidney to a human body and watched it begin to work, a small step in the decades-long quest to one day use animal organs for lifesaving transplants.
Pigs have been the most recent research focus to address the organ shortage, but among the hurdles: A sugar in pig cells, foreign to the human body, causes immediate organ rejection. The kidney for this experiment came from a gene-edited animal, engineered to eliminate that sugar and avoid an immune system attack.
Surgeons attached the pig kidney to a pair of large blood vessels outside the body of a deceased recipient so they could observe it for two days. The kidney did what it was supposed to do — filter waste and produce urine — and didn't trigger rejection.
"It had absolutely normal function," said Dr. Robert Montgomery, who led the surgical team last month at NYU Langone Health in New York. "It didn't have this immediate rejection that we have worried about."
This research is "a significant step," said Dr. Andrew Adams of the University of Minnesota Medical School, who was not part of the work. It will reassure patients, researchers and regulators "that we're moving in the right direction."
The dream of animal-to-human transplants, or xenotransplantation, dates to the 17th century with stumbling attempts to use animal blood for transfusions. By the 20th century, surgeons were attempting transplants of organs from baboons into humans, notably Baby Fae, a dying infant, who lived 21 days with a baboon heart.
With no lasting success and much public uproar, scientists turned from primates to pigs, tinkering with their genes to bridge the species gap.
Pigs have advantages over monkeys and apes. They are produced for food, so using them for organs raises fewer ethical concerns. Pigs have large litters, short gestation periods and organs comparable to those of humans.
Pig heart valves also have been used successfully for decades in humans. The blood thinner heparin is derived from pig intestines. Pig skin grafts are used on burns, and Chinese surgeons have used pig corneas to restore sight.
Kidney ready for transplantation from a live donor Image credit: wikimedia commons
In the NYU case, researchers kept a deceased woman's body on a ventilator after her family agreed to the experiment. The woman had wished to donate her organs, but they weren't suitable for traditional donation.
'Good could come from this'
The family felt "there was a possibility that some good could come from this gift," Montgomery said.
Montgomery himself received a transplant three years ago, a human heart from a donor with hepatitis C because he was willing to take any organ.
"I was one of those people lying in an ICU waiting and not knowing whether an organ was going to come in time," he said.
Several biotech companies are in the running to develop suitable pig organs for transplant to help ease the human organ shortage. More than 90,000 people in the U.S. are in line for kidney transplants. Every day, 12 die while waiting.
The advance is a win for Revivicor, a subsidiary of United Therapeutics, the company that engineered the pig and its cousins, a herd of 100 raised in tightly controlled conditions at a facility in Iowa.
The pigs lack a gene that produces alpha-gal, the sugar that provokes an immediate attack from the human immune system.
In December, the Food and Drug Administration approved the gene alteration in the Revivicor pigs as safe for human food consumption and medicine.
But the FDA said developers would need to submit more paperwork before pig organs could be transplanted into living humans.
"This is an important step forward in realizing the promise of xenotransplantation, which will save thousands of lives each year in the not-too-distant future," said United Therapeutics CEO Martine Rothblatt in a statement.
Experts say tests on nonhuman primates and last month's experiment with a human body pave the way for the first experimental pig kidney or heart transplants in living people in the next several years.
Raising pigs to be organ donors feels wrong to some people, but it may grow more acceptable if concerns about animal welfare can be addressed, said Karen Maschke, a research scholar at the Hastings Center, who will help develop ethics and policy recommendations for the first clinical trials under a grant from the National Institutes of Health.
"The other issue is going to be: Should we be doing this just because we can?" Maschke said. (VOA/RN)
Keywords: Transplant, Pig, Human, Kidney, FDA
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Developed by the Indian Institute of Tropical Meteorology (IITM), Pune, a Decision Support System (DSS) that extends the ability of the existing air quality early warning system (AQEWS) to have decision-making capability for air quality management in Delhi-NCR was launched on Tuesday.
The website for the DSS (https://ews.tropmet.res.in/dss/) is designed to help the Commission for Air Quality Management for NCR and Adjoining Areas (CAQM) by delivering quantitative information about the contribution of emissions from Delhi and its 19 surrounding districts; the contribution of emissions from eight different sectors in Delhi; and the contribution from biomass-burning activities in the neighbouring states.
These information would assist in managing the air quality in a timely manner, a release from the Ministry of Earth Sciences said.
The need was stated by the CAQM, which was formed by the Ministry of Environment, Forest and Climate Change, during a meeting held in January 2021.
Recently, the Commission reviewed the progress made by IITM and had in principle approved the current version of DSS for air quality management in the Delhi-NCR. The IITM has also developed a new website for DSS with the entire system made operational, the release said.
Union Minister of State for Earth Sciences, Jitendra Singh, while launching the website for AQEWS on the occasion of 'Azadi Ka Amrit Mahotsav' week organised by the Ministry of Earth Sciences, said, "DSS is a significant contribution to 'Azadi Ka Amrit Mahotsav' on behalf of MoES and IITM and suggestions are invited on this issue."
The website also has a feature whereby the users can create their own emission reduction scenarios (from 20 different districts, including Delhi) so as to examine the possible projected improvement in air quality in Delhi for the next five days.
"This information would explicitly highlight the most important emission sources responsible for the degradation of air quality in Delhi and suggest possible solutions to ameliorate the same. With a plethora of quantitative data, the AQEWS integrated with DSS could become a user-friendly tool for air-quality management in and around Delhi," the release said. (IANS/JB)
Keywords: Delhi, India, Pollution, IITM, Ministry of Earth Sciences
On the first day of the two-day meeting of BJP and Rashtriya Swayamsevak Sangh (RSS) leaders on Tuesday, discussions were held on important issues related to education and the National Education Policy-2020. Apart from senior RSS leader Suresh Soni, representatives of various organisations associated with the Sangh Parivar -- working in the field of education -- were present in the meeting in New Delhi.
According to sources, Union Education Minister Dharmendra Pradhan, who attended the meeting on behalf of the government, shared information related to the National Education Policy-2020 and the government's policy on important issues related to the education sector. Pradhan also shared details of the efforts being made by the government in the field of education.
Discussions were also held regarding the impact of the situation arising out of Corona and how much it has affected the education sector. In the meeting, the RSS leaders asked several questions and provided suggestions to the Union Minister regarding the education policy of the government.
According to the sources, RSS wants the policy to be implemented expeditiously. All aspects related to the policy were discussed in Tuesday's meeting. On the second and the last day of the meeting on Wednesday, special issues related to education will be discussed in which representatives of various organisations of the Sangh, Union Ministers and several BJP leaders will be take part.
Meanwhile, in order to convey its point of view to the government on various issues, the Sangh keeps on calling such coordination meetings related to specific issues, in which RSS representatives -- working in that particular area -- provide feedback to the government. (IANS/JB)
Keywords: BJP, RSS, New Education Policy, Education, India