Friday December 6, 2019

This Pill Could end Daily Insulin Jabs For Diabetics

The enteric coating is biocompatible, easy to manufacture, and can be stored for up to two months at room temperature without degrading

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The findings, published in the journal Diabetologia, were based on data from nearly 2,800 children with a first-degree relative with Type-1 diabetes.
New shoe insole could treat diabetic foot ulcers. Pixabay

Researchers, including one of Indian-origin, have developed a ‘holy grail’ of insulin in a pill that could help diabetics keep their blood sugar levels in check.

For up to 40 million people with Type-1 diabetes worldwide, a painful needle prick once or twice daily is necessary for delivering the insulin that their bodies cannot produce on their own, and failing to adhere to the regimen (due to pain, phobia of needles) can lead to poor glycemic control causing serious health complications.

The new approach carries insulin in an ionic liquid comprised of choline and geranic acid that is then put inside a capsule with an acid-resistant enteric coating.

“Once ingested, insulin must navigate a challenging obstacle course before it can be effectively absorbed into the bloodstream,” said Samir Mitragotri, Professor at the Harvard University.

“Our approach is like a Swiss Army knife, where one pill has tools for addressing each of the obstacles that are encountered,” he added.

Representational image.
Representational image. Pixabay

The enteric coating is biocompatible, easy to manufacture, and can be stored for up to two months at room temperature without degrading.

This polymer coating resists the breakdown by gastric acids in the gut as well as dissolves when it reaches a more alkaline environment in the small intestine, where the ionic liquid carrying insulin is released.

The choline-geranic acid formulation also was shown to be adept at penetrating two final barriers – the layer of mucus lining the intestine and the tight cell junctions of the intestine wall, through which large-molecule drugs such as insulin cannot easily pass.

Also Read: TB Vaccine May Help to Control Type-1 Diabetes, Says Study

The findings, published in the Proceedings of the National Academy of Sciences, also showed that the oral delivery of insulin could also mitigate many of the disease’s life-threatening side effects that result from patients failing to give themselves required injections.

“It has been the holy grail of drug delivery to develop ways to give protein and peptide drugs like insulin by mouth, instead of injection,” the researchers said. (IANS)

  • Joshua Carpenter

    For people with Type-1, unless you have a pump, you are doing way more than one or two needle pricks for the purpose of delivering insulin. You will have your long-lasting basal insulin, which is typically twice a day. And then you are doing injections at every meal (plus any corrections for snacks or whatever). So, most type-1 diabetics are probably at least doing 5+ injections a day. Of course, if you have a pump, that will not be the case.

    I would be curious as to the composition of the enteric coating (cellulose-based, PVAP, etc.). However, this appears to be excellent news and looks promising.

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  • Joshua Carpenter

    For people with Type-1, unless you have a pump, you are doing way more than one or two needle pricks for the purpose of delivering insulin. You will have your long-lasting basal insulin, which is typically twice a day. And then you are doing injections at every meal (plus any corrections for snacks or whatever). So, most type-1 diabetics are probably at least doing 5+ injections a day. Of course, if you have a pump, that will not be the case.

    I would be curious as to the composition of the enteric coating (cellulose-based, PVAP, etc.). However, this appears to be excellent news and looks promising.

Next Story

Cardiovascular Events Cause 58% Deaths Among Diabetics

The medicine likewise helps lower the amount of sodium in the body and reduce triglyceride levels and blood pressure

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Diabetes
According to the researchers, these novel findings may provide the basis for new therapies for patients who have heart disease complicated by diabetes. Pixabay

Fifty-eight percent of deaths among people with type 2 diabetes are due to cardiovascular events, a leading Mexican expert has said.

“Patients who live with this disease have a greater risk of premature death or disability derived from cardiovascular events,” Hector Sanchez Mijangos, President of the Mexican Diabetes Federation, told Efe news.

The specialist said that the high glucose levels associated with diabetes damage blood vessels, resulting in problems with blood pressure and vision, joint pain and other maladies.

Data from the World Health Organization indicate that more 442 million people suffer from type 2 diabetes.

Mexico’s Health Secretariat has found that while roughly 13 million inhabitants of the Aztec nation are living with diabetes, only half of those afflicted know they have the disease.

In 2015 alone, according to Mijangos, there were more than 98,000 premature deaths in Mexico related to diabetes and the average age of those who died was 66.7 years old.

Diabetes
Representational image. Pixabay

“This is regrettable, because these people could have lived roughly another 15 years,” he said.

According to the 2012 National Health and Nutrition Survey, only 25 percent of Mexicans suffering with diabetes are managing their condition adequately.

That figure illustrates “why our greatest challenge continues to be access and adherence to treatment”, Mijangos said.

Also Read- Researchers Discover Balance of Two Enzymes That May Help Treat Pancreatic Cancer

To improve treatment options, Mexican health authorities in January issued an approval for the use of canagliflozin, a drug that helps reduce the amount of blood glucose reabsorbed by the kidneys, which in turns causes more glucose to be eliminated through urination.

“With this medicine, a person can lose 100 milligrams of glucose per day as well as about 400 kilocalories (4,000 calories) a day, which also helps with weight loss,” Mijangos said.

The medicine likewise helps lower the amount of sodium in the body and reduce triglyceride levels and blood pressure.

A scientific trial involving more than 10,000 patients worldwide showed that when combined with conventional treatment, canagliflozin can reduce the incidence of cardiovascular events by up to 18 percent. (IANS)