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Participants' hair colour, the number of severe sunburns they had received in their lifetime and any family history of skin cancer were also taken into account. Pixabay

A targeted three-drug combination therapy resulted in median overall survival of nine months for patients with advanced bowel cancer compared to 5.4 months for current standard-of-care treatment, showed the results of a phase-3 clinical trial.

The data suggested that the three-drug combination, encorafenib, binimetinib and cetuximab, should replace chemotherapy for patients with metastatic colorectal cancer who have a BRAF gene flaw. Metastatic cancer can spread from one organ to another.


BRAF mutations are estimated to occur in up to 15 per cent of patients with metastatic colorectal cancer, with V600E being the most common BRAF mutation and representing a poor prognosis for these patients.


The data suggested that the three-drug combination, encorafenib, binimetinib and cetuximab, should replace chemotherapy for patients with metastatic colorectal cancer who have a BRAF gene flaw. Pixabay

“This study builds on a decade of research into the tumour biology of BRAF-mutated colorectal cancer, and reflects a rationale combination to address the vulnerabilities unique to this tumour,” said principal investigator Scott Kopetz, Associate Professor at the University of Texas MD Anderson Cancer Center in the US.

ALSO READ: BP Lowering Drug May Increase Risk of Bowel Condition, Find Researchers

“We are encouraged to see a meaningful improvement in outcomes with this new regimen for our patients,” Kopetz added. The international study was a multi-institutional collaboration with over 200 centres worldwide. The clinical trial involved 665 metastatic colorectal cancer patients with BRAF mutation. The findings were presented at the European Society for Medical Oncology (ESMO) World Congress on Gastrointestinal Cancer 2019 in Barcelona, Spain. (IANS)


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Sports betting has become increasingly popular among the youth in recent times

Sports betting has been around for centuries for the audience to not only watch the sport but to get more deeply involved in the match. It is a fun and often profitable activity for the viewer to win some extra fortune or simply get some extra sweat while watching the game. At first glance, sports betting may look like it's pure luck, but when you indulge deeper into the activity you realize it is more of a calculative and research activity than just pure luck. We must note that yes, luck does play a certain role to some extend but a win is not completely dependent on luck, if you're putting your bets on a certain team you have to make sure to do some research about the players on the team, history of wins and losses of the team and compare the probability of winning and then place bets.

Even though sports betting has existed since the ancient era, it was not until recently that it became increasingly popular among the youth. This happened due to the legalization of the activity and the rise of online sports betting. The technological revolution has expanded the sports betting industry, offering the bettors new markets and ways to bet. The only major difference between online bookmarkers and traditional brick-and-mortar venues of sports betting is that now you can place bets online from your mobile devices, laptops, computers etc.

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File

The government of Assam has recently consented to translate the research-based book by- Shri Salil Gewali titled "Great Minds on India"

It is indeed good news that the book showcasing the wisdom of India in the eyes of Western intellectuals is getting due recognition and appreciation from other states and abroad. After Karnataka and Punjab, the Government of Assam has recently consented to translate the research-based book by Shillong-based author - Shri Salil Gewali titled "Great Minds on India". The Chief Minister of Assam - Shri Himanta Biswa Sarma was amazed to know that so many top western scientists and philosophers have drawn a considerable amount of inspiration from ancient scriptures of India, particularly in the studies of modern physics, linguistic and astronomy. In the recent meeting with the author, the Chief Minister had highly appreciated Gewali's book and promised to read it thoroughly. Gewali's book was also approved for translation in the year 2020 by the former Chief Minister – Shri Sarbananda Sonowal but due to COVID-19, the translation work was delayed.

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VOA

Supporters of the 2022 Beijing Winter Olympics cheer as they mark the start of the 100 days countdown to the opening of the Winter Olympics in Beijing, China, Oct. 26, 2021

BEIJING — Chinese organizers have confirmed participants in next year's Winter Olympics will be strictly isolated from the general population and could face expulsion for violating COVID-19 restrictions.

Vice mayor and Beijing 2022 organizing committee official Zhang Jiandong told reporters Wednesday that those taking part in the games beginning Feb. 4 must remain in a "closed loop" for training, competing, transport, dining and accommodation.

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