Tuesday, April 20, 2021
Home Life Style Health & Fitness Tissue Healing in Brain Can Lead To Tumour Growth, Says Study

Tissue Healing in Brain Can Lead To Tumour Growth, Says Study

The finding, published in the journal Nature Cancer, could lead to a new therapy for glioblastoma patients who currently have limited treatment options with an average lifespan of 15 months after diagnosis, the researchers said

Researchers have found that the healing process that follows a brain injury — from trauma to infection and stroke — could spur tumour growth.

“Our data suggest that the right mutational change in particular cells in the brain could be modified by injury to give rise to a tumour,” said Peter Dirks, Professor at the University of Toronto.

The finding, published in the journal Nature Cancer, could lead to a new therapy for glioblastoma patients who currently have limited treatment options with an average lifespan of 15 months after diagnosis, the researchers said.

“Glioblastoma can be thought of as a wound that never stops healing,” Dirks said. “We’re excited about what this tells us about how cancer originates and grows, and it opens up entirely new ideas about treatment by focusing on the injury and inflammation response,” he added.

Please Follow NewsGram on Facebook To Get Latest Updates!

The researchers applied the latest single-cell RNA sequencing and Machine Learning (ML) technologies to map the molecular make-up of the glioblastoma stem cells (GSCs), which Dirks’ team previously showed are responsible for tumour initiation and recurrence after treatment.

They found new sub-populations of GSCs that bear the molecular hallmarks of inflammation and which are commingled with other cancer stem cells inside patients’ tumours. It suggests that some glioblastomas start to form when the normal tissue healing process, which generates new cells to replace those lost to injury, gets derailed by mutations — possibly many years before patients become symptomatic, Dirks said.

Once a mutant cell becomes engaged in wound healing, it cannot stop multiplying because the normal controls are broken and this spurs tumour growth, according to the study.

The team collected GSCs from 26 patients’ tumours and expanded them in the lab to obtain sufficient numbers of the rare cells for analysis. Almost 70,000 cells were analyzed by single-cell RNA sequencing, which detects what genes are switched on in individual cells — an effort led by Laura Richards, a graduate student in Pugh’s lab.

Brain Cell
Researchers have found that the healing process that follows a brain injury — from trauma to infection and stroke — could spur tumour growth. Unsplash

The data confirmed extensive disease heterogeneity, meaning that each tumour contains multiple sub-populations of molecularly distinct cancer stem cells, making recurrence likely as existing therapy is unable to wipe out all the different sub-clones.

A closer look revealed that each tumour has either of the two distinct molecular states – termed “Developmental” and “Injury Response” – or a gradient between the two. According to the researchers, the developmental state is a hallmark of the glioblastoma stem cells and resembles that of the rapidly dividing stem cells in the brain before birth.

ALSO READ: India Tourism Mart To Be Held In A Virtual Format

But the second state came as a surprise. The researchers termed it “Injury Response” because it showed an upregulation of immune pathways and inflammation markers such as interferon and TNFalpha, which are indicative of wound healing processes. (IANS)

STAY CONNECTED

19,507FansLike
362FollowersFollow
1,773FollowersFollow

Most Popular

Why This Exoplanet Is At Large Distance From Sun

A giant planet orbiting at a large distance around a sun-like star has presented a puzzle to astronomers because it does not seem to...

When An Innocent Prank Goes Horribly Wrong

Natasha, Riya, Anjali, and Katherine were best friends in college - each different from the other yet inseparable - until that night. It was...

Beauty Trends, Grooming Tools And Self Pampering During Lockdown

After a tough 2020, most businesses saw a revival, some movement, and an upswing in the first quarter of 2021. To gain an insight...

Satellite Based Real Time Monitoring Of Himalayan Terrain May Help Avoid Disasters

To avoid the Chamoli mishap from recurring, the Ministry of Science and technology with IIT Kanpur has conducted a study on how the satellite-based...

Anupam Kher: I Always See Myself In The New People

Actor Anupam Kher has been there, done it all -- from Bollywood to Hollywood. His secret of survival over the decades, he would tell...

India Likely To Be Third Contributor To Global GDP By 2040: Report

While China will overtake the United States as the largest economy in the world by 2040, India will be a distant third contributor to...

E-Commerce, OTT And Gaming Witnessed Over 100 Percent Growth In 2020

Amid the pandemic, online payments, indoor entertainment, and gaming witnessed over 100 percent growth in India last year, a new report said on Tuesday. As...

Vaccination Against Covid Safe In People With High-Risk Allergies: Study

Severe allergic reactions to Covid-19 vaccines remain exceedingly rare, thus people with high-risk allergy histories can safely take the jabs, according to a study...

Recent Comments