Friday December 14, 2018

Beware! Tobacco, Poor Diet, and Mental Disorders are Leading Causes of Poor Health and you may be at Risk too!

According to a new study, deaths from noncommunicable, or chronic, diseases such as cardiovascular disease and diabetes have caused 72 percent of all deaths worldwide

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A heavyset man rests on a bench in Jackson, Miss. (VOA)
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London, September 15, 2017 : Heart disease and tobacco ranked with conflict and violence among the world’s leading cause of poor health and the biggest killers in 2016, while poor diets and mental disorders caused people the greatest poor health, a large international study has found.

The Global Burden of Disease (GBD) study, published in The Lancet medical journal, found that while life expectancy is increasing, so too are the years people live in poor health. The proportion of life spent being ill is higher in poor countries than in wealthy ones.

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“Death is a powerful motivator, both for individuals and for countries, to address diseases that have been killing us at high rates. But we’ve been much less motivated to address issues leading to illnesses,” said Christopher Murray, director of the Institute for Health Metrics and Evaluation (IHME) at the University of Washington, which led the study.

He said a “triad of troubles” — obesity, conflict and mental illness — is emerging as a “stubborn and persistent barrier to active and vigorous lifestyles.”

Diet critical

The IHME-led study, involving more than 2,500 researchers in about 130 countries, found that in 2016, poor diet was associated with nearly one in five deaths worldwide. Tobacco smoking killed 7.1 million people.

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Diets low in whole grains, fruit, nuts and seeds, fish oils and high in salt were the most common risk factors, contributing to cases of obesity, high blood pressure, high blood sugar and high cholesterol.

The study found that deaths from firearms, conflict and terrorism have increased globally, and that noncommunicable, or chronic, diseases such as cardiovascular disease and diabetes caused 72 percent of all deaths worldwide.

Heart disease was the leading cause of premature death in most regions and killed 9.48 million people globally in 2016.

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Mental illness was found to take a heavy toll on individuals and societies, with 1.1 billion people living with psychological or psychiatric disorders and substance abuse problems in 2016.

Major depressive disorders ranked in the top 10 causes of ill health in all but four countries worldwide.

The GBD is funded by the Bill & Melinda Gates Foundation global health charity and gives data estimates on 330 diseases, causes of death and injuries in 195 countries and territories. (VOA)

 

 

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New Drug Offers Treatment For Diabetes-Related Blindness

The researchers now plan to conduct a full-scale clinical trial, Gamble said

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new policy will see the launch of 12 programmes relevant to private schools across the emirate
New drug offers hope for diabetes-related blindness.

In a major breakthrough, Australian scientists have developed a new drug that offers treatment for people suffering from diabetic retinopathy — the main cause of blindness from diabetes.

The debilitating disease occurs when tiny blood vessels in the retina, responsible for detecting light, leak fluid or haemorrhage.

While treatment options include laser surgery or eye injections of anti-vascular endothelial growth factor (VEGF), they are not always effective or can result in side effects, highlighting the need for alternative therapeutic approaches.

The team from the Centenary Institute in Sydney developed a novel drug CD5-2, which in mouse models was found to mend the damaged blood retinal barrier and reduce vascular leakage.

“We believe CD5-2 could potentially be used as a stand-alone therapy to treat those patients who fail to respond to the anti-VEGF treatment. It may also work in conjunction with existing anti-VEGF treatments to extend the effectiveness of the treatment,” said lead author Ka Ka Ting from the Institute.

“With limited treatment options currently available, it is critical we develop alternative strategies for the treatment of this outcome of diabetes,” Ting added.

Diabetes
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The key process involved in diabetic retinopathy pathology is the breakdown of the blood-retinal barrier (BRB), which is normally impermeable. Its integrity relies on how well capillary endothelial cells are bound together by tight junctions. If the junctions are loose or damaged, the blood vessels can leak.

In the study, reported in the journal Diabetologia, CD5-2 was found to have therapeutic potential for individuals with vascular-leak-associated retinal diseases based on its ease of delivery and its ability to reverse vascular dysfunction as well as inflammatory aspects in animal models of retinopathy.

Previous studies have shown that CD5-2 can have positive effects on the growth of blood vessels.

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“This drug has shown great promise for the treatment of several major health problems, in the eye and in the brain,” said Professor Jenny Gamble, head of Centenary’s Vascular Biology Programme.

The researchers now plan to conduct a full-scale clinical trial, Gamble said. (IANS)