Thursday May 23, 2019

Consuming Tomatoes Can Help to Fight Liver Cancer, Inflammation

Eat tomatoes to fight liver cancer, inflammation

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Tomatoes (Representational image). Pixabay

Higher consumption of tomatoes could be associated with a decreased risk of liver cancer caused by high-fat diets, a study has found.

The study, conducted on mice, showed that tomatoes are rich in lycopene—a strong antioxidant, anti-inflammatory and anti-cancer agent—which helps in effectively reducing fatty liver disease, inflammation and liver cancer development.

“Consuming whole foods like tomatoes and processed tomatoes from sauces, tomato paste, canned whole tomato products, ketchup and juice, provides the best source of lycopene,” said Xiang-Dong Wang, Professor at Tufts University in the US.

Interestingly, we observed that tomato powder is more effective than the same dose of purified lycopene supplementation to prevent liver cancer development, said Wang.

This could be due to the potential beneficial effects of other nutrients in a whole tomato, such as vitamin E, vitamin C, folate, minerals, phenolic compounds and dietary fibres.

Eating apples and tomatoes may slow the declining of lungs
Eat tomatoes to prevent liver cancer. Wikimedia Commons

In addition, feeding mice tomato powder increased the richness and diversity of beneficial microbiota and prevented the over-growth of some bacteria related to inflammation, said the study, published in the journal Cancer Prevention Research.

For the study, infant mice were infected with a liver carcinogen and then fed an unhealthy high-fat diet similar to a Western diet, with or without tomato powder containing lycopene.

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Other foods including guava, watermelon, grapefruit, papaya, and sweet red pepper also contain lycopene, but in much lower concentrations compared to tomatoes.

Eating tomatoes and tomato products such as tomato sauce rich in lycopene is also associated with a lower risk of cardiovascular disease, osteoporosis, diabetes, and certain cancers, including prostate, lung, breast and colon cancer, the study showed. (IANS)

Next Story

Know Which Hormone in Female Protects Them From Liver Cancer!

Inhibiting testosterone production in male rodents increased their adiponectin levels and reduced tumour growth. 

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Balversa is the first approved drug in a class known as FGFR inhibitors that targets growth factor receptors involved in cell growth and division. Pixabay

Researchers have discovered that a hormone — present at higher levels in women — can keep them away from liver cancer, suggesting the disease is more common in men.

The study showed that a potential contributor to this gender disparity is adiponectin, a hormone secreted by fat cells that helps control the body’s metabolism.

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Importantly, the study suggested that adiponectin and metformin — a common antidiabetic drug — could be used as novel treatments for liver cancer. Pixabay

The hormone activates two proteins inside liver cells, known as p38 and AMPK, that block cell proliferation and impair tumour growth, said the study, published in the Journal of Experimental Medicine.

“Circulating adiponectin levels have been reported to be higher in women than in men,” said Guadalupe Sabio at the Spanish National Center for Cardiovascular Research (CNIC) in Spain.

Similar to humans, male mice are more also prone to hepatocellular carcinoma (HCC) — the most common form of liver cancer — than females, as the increased levels of adiponectin in female mice protect them from HCC, the study said.

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The study showed that a potential contributor to this gender disparity is adiponectin, a hormone secreted by fat cells that helps control the body’s metabolism. Pixabay

Inhibiting testosterone production in male rodents increased their adiponectin levels and reduced tumour growth.

Importantly, the study suggested that adiponectin and metformin — a common antidiabetic drug — could be used as novel treatments for liver cancer.

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Sabio said that adiponectin’s role in HCC is controversial and needed further investigation.

Liver cancer is the fourth leading cause of cancer-related deaths worldwide. (IANS)