Sunday March 29, 2020

Here’s Why Too Short, Long Sleep Can Lead To Incurable Lung Disease

The researchers then showed, that pulmonary fibrosis is associated with short and long sleep duration using human data from the UK Biobank

0
//
Sleep
Our internal body clocks regulate nearly every cell in the human body, driving 24-hour cycles in many processes such as sleeping, hormone secretion and metabolism. Pixabay

People who regularly sleep for more than 11 hours or less than four hours are 2-3 times more likely to have the incurable lung disease, pulmonary fibrosis, compared to those that sleep for seven hours in a day, researchers have found.

They attribute this association to the body clock.

The study, published in the journal Proceedings of the National Academy of Sciences, also reveals that targeting the body clock reduces fibrosis in vitro, revealing a potential target for this incurable disease that kills about 5,000 people, a year in the UK,the same number as leukaemia.

“Pulmonary fibrosis is a devastating condition which is incurable at present. Therefore, the discovery that the body clock is potentially a key player potentially opens new ways to treat or prevent the condition,” said study lead author John Blaikley from The University of Manchester in UK.

“More work need to be done around studying the association between pulmonary fibrosis and sleep duration to establish both causation and reproducibility,” Blaikley said. “If these results are confirmed, then sleeping for the optimal time may reduce the impact of this devastating disease,” he added.

Our internal body clocks regulate nearly every cell in the human body, driving 24-hour cycles in many processes such as sleeping, hormone secretion and metabolism. In the lungs, the clock is mainly located in the main air carrying passages – the airways.

However, the team discovered that in people with lung fibrosis, these clock oscillations extend out to the small air spaces, called alveoli. Studies in mice revealed that by altering the clock mechanism it was possible to disrupt the fibrotic process making the animals more likely to develop pulmonary fibrosis.

The researchers then showed, that pulmonary fibrosis is associated with short and long sleep duration using human data from the UK Biobank.

The link between sleep duration and lung fibrosis is similar in strength to other known risk factors for this disease. People who report they regularly sleep four hours or less in a day doubled their chance of having pulmonary fibrosis while those sleeping 11 hours or longer in a day tripled their chance of having the disease, compared to those sleeping seven hours per day.

Lungs
People who regularly sleep for more than 11 hours or less than four hours are 2-3 times more likely to have the incurable lung disease, pulmonary fibrosis, compared to those that sleep for seven hours in a day, researchers have found. Pixabay

Smaller, but still elevated, risks were also seen in people who like to stay up late at night or those who do shift work. The researchers explain their findings by the discovery that a core clock protein (REVERBa) which alters the production of a key protein in lung fibrosis (collagen). This is an exciting finding, because chemical compounds can alter the function of REVERBa, said the researchers.

The researchers were able to show that one of these REVERBa compounds can reduce collagen in lung slices from people with this disease.

ALSO READ: What is the Potential of Virtual Reality in the Workplace?

The discovery that the clock plays a role in fibrosis suggests that altering these oscillations could become an important therapeutic approach, the research said. (IANS)

 

Next Story

All Private Hospitals and Doctors Should Lend their Helping Hands

It is the time when all “private” doctors, health clinics and nourishing homes should give serious thought towards helping the governments

0
doctors hospital
Doctors and elite hospitals should come forwards with their open hearts. Pixabay

SALIL GEWALI

If private medical professionals still choose to remain on lockdown at home 
then the groan and moan of humanity will unmask them forever.  

A friend in need is the friend indeed. But today one should change it a little bit to be more relevant by saying – “a doctor in need is a doctor indeed”. Because the doctors are our most wanted friends now. They are the ones who could save us from the Covid malady.

It is the time when all “private” doctors, health clinics and nourishing homes should give serious thought towards helping the governments in their respective countries by extending their voluntary services in every possible way.

doctors hospital
If private doctors and medical professionals still choose to remain on lockdown at home
then the groan and moan of humanity will unmask them forever.

All doctors and owners of “private” medical institutes should agree that this is the most “unprecedented” pandemic health crisis mankind has ever witnessed, at least in modern times. So, the “private health professionals” and elite hospitals should come forwards with their open hearts. In fact, is it not the medical fraternity who has seen life from the close proximity of the “death”? One’s materialistic possession, his high ambition and dream seems like  an illusion when deaths come knocking the door? Look at the increasing fatalities in Italy and Spain due to raging coronavirus infection. The USA is scrambling to get its medical equipment together. Is it not heart-wrenching! The government of Italy has screamed in tears pleading for help as it’s medical wherewithal is almost exhausted. What more — Prince Charles is in quarantine, so is now UK Prime Minister  Boris Johnson and his Health Secretary who tested positive for the deadly Corona-virus.

doctors hospital
Doctors in overalls stretch a patient under intensive care into the newly built Columbus Covid 2 temporary hospital to fight the new coronavirus infection.

This pandemic crisis is in fact an “alarm bell” tolled which should prompt us for a real introspection. The condition the world top countries are confronting should make us “convince” that our life is afloat on the bubble of “uncertainty”. Any moment our end can come. The life on this earth is no less than a temporary sojourn — the fact we can see and feel more clearly now than ever before.

doctors hospital
All doctors and owners of “private” medical institutes should agree that this is the most “unprecedented” pandemic health crisis mankind has ever witnessed.

So, one strongly believes that in these trying times all “private medical professionals” and proprietors of all nourishing homes and hospitals across the world should stand up to demonstrate their compassion towards the aggrieved humanity. They should open the doors of their hospitals and clinics for the treatment of the COVID patients without discrimination and with utmost urgency.   Needless to say, by all accounts, this is their moral obligation and the prime duty. However, if they still choose to remain on lockdown at home and keep silent then the groan and moan of humanity will unmask them forever.

Also Read- Can COVID-19 Test Results Arrive in Minutes? Scientists Answer This Question for You

A India-based writer and researcher, Salil Gewali is best known for his research-based work entitled ‘Great minds on India’ which has earned worldwide appreciations. Translated into twelve languages, his book has been prefaced by a world-acclaimed NASA Chief scientist – Dr. Kamlesh Lulla of Houston, USA 

[ Disclaimer: The pictures used in the article are supplied by the author, NewsGram has no intention of infringing copyrights. ]