Thursday February 21, 2019

Common Toothpaste Ingredient May Promote Colon Cancer

Previous research has suggested that triclosan can have toxic effects at high doses, but the health effects of lower concentrations that a person might be exposed to remain unclear

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Common Toothpaste Ingredient May Promote Colon Cancer
Common Toothpaste Ingredient May Promote Colon Cancer. Pixabay

Using triclosan, an antibacterial and antifungal agent found in hand soaps and toothpastes among other consumer products, can potentially cause colon inflammation and cancer, finds a study on mice.

The study, reported in Science Translational Medicine, suggests that short-time treatment with low-dose triclosan caused low-grade colonic inflammation, and exaggerated disease development of colitis and colitis-associated colon cancer in mice.

“These results, for the first time, suggest that triclosan could have adverse effects on gut health,” said Guodong Zhang at the University of Massachusetts-Amherst, US.

Previous research has suggested that triclosan can have toxic effects at high doses, but the health effects of lower concentrations that a person might be exposed to remain unclear.

For the new study, the team fed mice with food containing various concentrations of triclosan for three weeks.

The results showed that mice treated with a concentration of triclosan that reflects the concentrations reported in human blood samples displayed more systemic and colonic inflammation compared to control animals.

Representational image.
Representational image. Pixabay

Furthermore, triclosan exposure increased the severity of colon inflammation in mouse models of inflammatory bowel disease — an effect that persisted even when low doses of the chemical were administered.

Triclosan treatment also increased tumour size and reduced survival in a separate group of rodents with colon cancer.

Interestingly, triclosan also reduced the diversity of commensal bacteria in the gut of mice, and germ-free mice were protected from the harmful effects, suggesting its pro-inflammatory actions may arise due to alteration of the gut microbiome.

Also Read: AI Outwits Doctors at Detecting Skin Cancer

The researchers stressed that further studies should assess the impact of triclosan on human gut health, and determine whether individuals with IBD or colon cancer could be more vulnerable to any adverse effects.

“Because this compound is so widely used, our study suggests that there is an urgent need to further evaluate the impact of triclosan exposure on gut health in preparation for the potential establishment of further regulatory policies,” said co-author Haixia Yang, a postdoctoral fellow at the varsity. (IANS)

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American Children Use More Toothpaste Than Recommended: Report

The CDC is a US federal agency under the Department of Health and Human Services and is headquartered in Atlanta, Georgia

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Common Toothpaste Ingredient May Promote Colon Cancer
Common Toothpaste Ingredient May Promote Colon Cancer. Pixabay

Many American children use more toothpaste than officially recommended, according to the Centers for Disease Control and Prevention (CDC) report, published on Friday.

“Analysis of 2013-16 data found that over 38 per cent of children aged three to six years used more toothpaste than recommended by the CDC and other professional organisations,” Xinhua news agency reported citing the report.

The recommended toothpaste amount for children at three to six years old is of pea-size, and for those under three about a rice grain, according to the report.

The CDC also noted that nearly 80 per cent of children aged 3 to 15 years started brushing later than the recommended age of six months.

Poor dental health may lead to risk of diabetes. Pixabay
US kids use excess toothpaste: Report. Pixabay

Fluoride use could help avoid tooth decay, but the CDC recommended children to begin using fluoride toothpaste at two years of age to prevent inadvertent ingestion of fluoride and the potential risk of dental fluorosis.

Also Read- Google Shows How Simple Steps Can Help You Feel Safer on Internet

The CDC suggested parents and caregivers to make sure that children brush teeth often enough with recommended amount of toothpaste.Health care professionals and organisations could also help by providing education.

The CDC is a US federal agency under the Department of Health and Human Services and is headquartered in Atlanta, Georgia. (IANS)