Monday August 20, 2018

Common Toothpaste Ingredient May Promote Colon Cancer

Previous research has suggested that triclosan can have toxic effects at high doses, but the health effects of lower concentrations that a person might be exposed to remain unclear

0
//
21
Common Toothpaste Ingredient May Promote Colon Cancer
Common Toothpaste Ingredient May Promote Colon Cancer. Pixabay
Republish
Reprint

Using triclosan, an antibacterial and antifungal agent found in hand soaps and toothpastes among other consumer products, can potentially cause colon inflammation and cancer, finds a study on mice.

The study, reported in Science Translational Medicine, suggests that short-time treatment with low-dose triclosan caused low-grade colonic inflammation, and exaggerated disease development of colitis and colitis-associated colon cancer in mice.

“These results, for the first time, suggest that triclosan could have adverse effects on gut health,” said Guodong Zhang at the University of Massachusetts-Amherst, US.

Previous research has suggested that triclosan can have toxic effects at high doses, but the health effects of lower concentrations that a person might be exposed to remain unclear.

For the new study, the team fed mice with food containing various concentrations of triclosan for three weeks.

The results showed that mice treated with a concentration of triclosan that reflects the concentrations reported in human blood samples displayed more systemic and colonic inflammation compared to control animals.

Representational image.
Representational image. Pixabay

Furthermore, triclosan exposure increased the severity of colon inflammation in mouse models of inflammatory bowel disease — an effect that persisted even when low doses of the chemical were administered.

Triclosan treatment also increased tumour size and reduced survival in a separate group of rodents with colon cancer.

Interestingly, triclosan also reduced the diversity of commensal bacteria in the gut of mice, and germ-free mice were protected from the harmful effects, suggesting its pro-inflammatory actions may arise due to alteration of the gut microbiome.

Also Read: AI Outwits Doctors at Detecting Skin Cancer

The researchers stressed that further studies should assess the impact of triclosan on human gut health, and determine whether individuals with IBD or colon cancer could be more vulnerable to any adverse effects.

“Because this compound is so widely used, our study suggests that there is an urgent need to further evaluate the impact of triclosan exposure on gut health in preparation for the potential establishment of further regulatory policies,” said co-author Haixia Yang, a postdoctoral fellow at the varsity. (IANS)

Click here for reuse options!
Copyright 2018 NewsGram

Next Story

Diet Soda May Keep Colon Cancer From Recurring: Researchers

Risk factors for colon cancer include obesity and poor diet

0
soda
The "soft drinks" were defined as caffeinated colas, caffeine-free colas and other carbonated beverages (such as diet ginger ale). Pixabay

People who drank diet soda after being treated for colon cancer are less likely to see a recurrence than those who didnt drink artificially-sweetened drinks, claims a Yale University study.

To reach this conclusion, researchers analysed 1,018 colon cancer patients.

Those who drank one or more 12-ounce artificially-sweetened drink a day saw a 46 per cent improvement in risk of cancer recurrence or death compared to those who didn’t drink such beverages, said the study published in the journal PLOS ONE.

The “soft drinks” were defined as caffeinated colas, caffeine-free colas and other carbonated beverages (such as diet ginger ale).

“Artificially sweetened drinks have a checkered reputation in the public because of purported health risks that have never really been documented,” said Charles S. Fuchs from the Yale University in Connecticut.

soda
Artificially sweetened drinks have a checkered reputation in the public because of purported health risks that have never really been documented. Pixabaay

“Our study clearly shows they help avoid cancer recurrence and death in patients who have been treated for advanced colon cancer and that is an exciting finding,” Fuchs added.

The research follows similar findings that showed that drinking coffee and eating tree nuts also may have a protective effect, Fuchs noted.

While various studies have suggested that poor dietary habits, such as high consumption of sugar-sweetened beverages, may increase risk of colon cancer recurrence and patient mortality, “for colon cancer patients who have trouble abstaining from sweet beverages, choosing artificially sweetened options over sugar-sweetened beverages may allow them to avoid those health ramifications”, the researchers explained.

Also Read: Baking Soda Useful For beauty regime

Risk factors for colon cancer include obesity and poor diet.

“Concerns that artificial sweeteners may increase the incidence of obesity, diabetes, and cancer have been raised, but studies on issues such as weight gain and diabetes have been very mixed, and, regarding cancer, epidemiologic studies in humans have not demonstrated such relationships,” the study explained.

According to Fuchs, “in terms of colon cancer recurrence and survival, use of artificially-sweetened drinks is not a health risk, but is a healthier choice”. (IANS)