Saturday August 24, 2019

Common Toothpaste Ingredient May Promote Colon Cancer

Previous research has suggested that triclosan can have toxic effects at high doses, but the health effects of lower concentrations that a person might be exposed to remain unclear

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Common Toothpaste Ingredient May Promote Colon Cancer
Common Toothpaste Ingredient May Promote Colon Cancer. Pixabay

Using triclosan, an antibacterial and antifungal agent found in hand soaps and toothpastes among other consumer products, can potentially cause colon inflammation and cancer, finds a study on mice.

The study, reported in Science Translational Medicine, suggests that short-time treatment with low-dose triclosan caused low-grade colonic inflammation, and exaggerated disease development of colitis and colitis-associated colon cancer in mice.

“These results, for the first time, suggest that triclosan could have adverse effects on gut health,” said Guodong Zhang at the University of Massachusetts-Amherst, US.

Previous research has suggested that triclosan can have toxic effects at high doses, but the health effects of lower concentrations that a person might be exposed to remain unclear.

For the new study, the team fed mice with food containing various concentrations of triclosan for three weeks.

The results showed that mice treated with a concentration of triclosan that reflects the concentrations reported in human blood samples displayed more systemic and colonic inflammation compared to control animals.

Representational image.
Representational image. Pixabay

Furthermore, triclosan exposure increased the severity of colon inflammation in mouse models of inflammatory bowel disease — an effect that persisted even when low doses of the chemical were administered.

Triclosan treatment also increased tumour size and reduced survival in a separate group of rodents with colon cancer.

Interestingly, triclosan also reduced the diversity of commensal bacteria in the gut of mice, and germ-free mice were protected from the harmful effects, suggesting its pro-inflammatory actions may arise due to alteration of the gut microbiome.

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The researchers stressed that further studies should assess the impact of triclosan on human gut health, and determine whether individuals with IBD or colon cancer could be more vulnerable to any adverse effects.

“Because this compound is so widely used, our study suggests that there is an urgent need to further evaluate the impact of triclosan exposure on gut health in preparation for the potential establishment of further regulatory policies,” said co-author Haixia Yang, a postdoctoral fellow at the varsity. (IANS)

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Filling Oreo with Toothpaste Earns YouTube Prankster a Jail Sentence

The 52-year-old homeless man reportedly vomited after ingesting the toothpaste cookies

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Oreo, Toothpaste, YouTube, Prankster
A Spanish YouTube star, who gave a homeless man an Oreo cookie filled with toothpaste. Pixabay

A Spanish YouTube star, who gave a homeless man an Oreo cookie filled with toothpaste, has been sentenced to 15 months in prison. He also owes $22,300 to his victim, The New York Times has reported.

The 52-year-old homeless man reportedly vomited after ingesting the toothpaste cookies. He later said he has “never been treated so poorly while living on the street”.

The prankster, known as ReSet to his followers on YouTube, whose real name is Kanghua Ren, was found guilty of violating the moral integrity of the homeless man.

He is unlikely to serve any time behind bars, however, Spanish law normally allows sentences under two years for first-time offenders in nonviolent crimes to be suspended, The New York Times report on Sunday said.

Oreo, Toothpaste, YouTube, Prankster
He is unlikely to serve any time behind bars. Pixabay

The YouTube star in his defence said that the video was just a “bad joke”.
“I do things to mount a show: People like what is morbid,” he told the court, according to the Spanish media.

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However, the judge noted that Ren had earned more than 2,000 euros from advertising revenues generated by the video, one of several he filmed in response to various challenges received from his followers, the report said. (IANS)