Never miss a story

Get subscribed to our newsletter


×
Study gives us hope for repurposing common drugs for young cancer patients desperately requiring better treatment options. Pixabay

In a major study, researchers have found that a commonly prescribed anti-depressant may halt the growth of a type of cancer known as childhood sarcoma.

In mice and laboratory cell experiments, the study, published in the journal Cancer Research, the research team ignited hopes of novel treatment strategies against this disease.


“This study gives us hope for repurposing common drugs for young cancer patients desperately requiring better treatment options,” said study lead author Caitrín Crudden from Karolinska Institutet in Sweden.

Follow NewsGram on Twitter to stay updated about the World news.

The study examined commonalities between two large groups of cell surface receptors, the so-called G protein-coupled receptors (GPCRs) and the receptor tyrosine kinases (RTKs).

GPCRs are targeted by more than half of all developed drugs to treat conditions such as allergies, asthma, depression, anxiety, and hypertension, but have so far not been widely used to treat cancers.

RTKs, on the other hand, are targeted by drugs against cancers, such as breast and colon cancers, due to their implication in a variety of cellular abnormalities.

Follow NewsGram on Instagram to keep yourself updated.

One receptor in the RTK family that plays a key role in many cancers, including childhood sarcoma, is the insulin-like growth factor receptor (IGF1R). However, previous attempts to develop anti-cancer drugs against this receptor have failed.


This strategy opens new possibilities of repurposing well-tolerated drugs to silence this tumor-driving receptor and thereby halt cancer growth. Pixabay

In this study, the researchers scrutinized the IGF1R and found that it shares a signaling module with the GPCRs, meaning it may be possible to affect its function through drugs targeting the GPCRs.

Want to read more in Hindi? Checkout: हरियाणा के सभी शहरों में लगेंगे सीसीटीवी कैमरे : स्थानीय निकाय मंत्री अनिल विज

This strategy opens new possibilities of repurposing well-tolerated drugs to silence this tumor-driving receptor and thereby halt cancer growth.

To test their hypothesis, the researchers treated childhood sarcoma cells and mouse models with Paroxetine, an anti-depressant drug that impairs a serotonin reuptake receptor that is part of the GPCR family.

They found that this drug significantly decreased the number of IGF1R receptors on the malignant cells and thereby suppressed the growth of the tumor.

ALSO READ: Very Few Consumers Think Their Food is Safe

The researchers also uncovered the molecular mechanism behind this cross-targeting.

“We have developed a novel strategy to control the activity of these tumor-driving receptors by striking the GPCRs,” said study author Leonard Girnita from Karolinska Institutet. (IANS)


Popular

Wikipedia

Even free VPNs can do as much, as long as you go with a trustworthy provider such as those linked at the start.

By- Tejas Maheta

Free VPNs tend to get a bad rap (and often for good reasons, which we'll discuss in a second). Still, there are some safe and free VPN services recommended by expats - just click the link for some solid options. Next, scroll on to see how you can put them to good use while you're abroad.

Keep Reading Show less
Photo by Sirisvisual on Unsplash

This update provides important security updates and is recommended for all users.

The Cupertino-based tech giant Apple has started rolling out iOS 12.5.5 to older models of the iPhone and iPad. "This update provides important security updates and is recommended for all users," Apple said in the release notes for iOS 12.5.5.

The update is available for the iPad Air, the iPad mini 2, and iPad mini 3, as well as the 6th gen iPod touch, iPhone 5s, iPhone 6, and iPhone 6 Plus. All of these devices were dropped from support with iOS 13. The iOS 12.5.5 update addresses issues related to maliciously crafted PDFs, web content, and apps.

ALSO READ: The September Event Of Apple Inc.

Apple had previously rolled out iOS 12.5.4 in June with security fixes for WebKit vulnerabilities and other issues. Apple has also started seeded the first betas of iOS 15.1 as well as iPadOS 15.1. After removing SharePlay in iOS 15 beta 2, Apple has re-enabled the feature in the iOS 15.1, iPadOS 15.1, and tvOS 15.1 betas. Apple decided to pull SharePlay from the iOS 15 launch because it was not properly functioning and was still riddled with issues.

It adds features to the Health app like support for storing health-related data for Covid-19 immunisations and test results. With the latest iOS 15.1 Beta, one can now add vaccination cards to the Apple Wallet application. (IANS/ MBI)

Keep Reading Show less
Flickr

The National Basketball Association (NBA) and Lakme Fashion Week, announced a collaboration to celebrate "NBA 75"

The National Basketball Association (NBA) and Lakme Fashion Week, announced a collaboration to celebrate "NBA 75" the leagues landmark 75th Anniversary Season in 2021-22. As part of the collaboration, the NBA and Lakme Fashion Week will offer fashion designers from across India the opportunity to submit designs for an "NBA 75" collection. Select designs will be evaluated by a panel comprised of fashion designers, industry experts and local influencers, with the winning designer announced at the upcoming October edition of Lakme Fashion Week.

The winner will then be mentored by a leading fashion expert and will work alongside the NBA on a capsule collection to commemorate NBA 75. The NBA 75 range, which will include jerseys, t-shirts, headwear, sweatpants, hoodies, jackets and other apparel, will be unveiled at Lakme Fashion Week in March 2022.

"We are excited to collaborate with Lakme Fashion Week and offer Indian designers the chance to express their vision in celebration of NBA 75," said NBA Asia Executive Vice President & Managing Director Scott Levy. "The NBA and its players are synonymous with fashion and culture, and this friendly competition will showcase the talent and passion that Indian designers have for basketball and the NBA during our landmark 75th Anniversary Season." The collection will be available for purchase after the event on the NBAStore.in and at select retail destinations. (IANS/ MBI)


Keep reading... Show less