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People with rare cancers have been out of luck — not only do most lack good treatments, but drug companies also don’t pursue them because of small potential sales. Now, a federal study that pools these folks gives them strength in numbers and new options.
The first results from this novel effort were revealed at an American Association for Cancer Research conference Sunday in Atlanta. They suggest that for people with one of these unusual diseases, there seems to be a way to predict who will benefit from a drug combo that boosts the immune system and who will not.
“For the patients that it works for, it’s phenomenal, it’s life-changing … but it’s not for everybody,” said one study leader, Dr. Sandip Patel of the University of California, San Diego’s Moores Cancer Center.
Brigitte Sagasser, 54, of San Marcos, California, is one study participant who seems to be benefiting. Her tumors have been shrinking since starting the treatment a year ago for a rare type of ovarian cancer that defied surgeries, chemotherapy and hormone therapy.
“I’ve tried all kinds of stuff before and nothing really helped in the long run,” she said. “I felt like I was kind of out of choices on what could be done.”
Rare cancers individually affect fewer than 6 in 100,000 people a year, but collectively make up 22% of all cancer cases. They include tumors in the brain, blood, glands, bones, and skin, and there’s often not even a study that patients can join to test an experimental drug or therapy.
“We’re trying to fill that gap” by funding the federal study, said Dr. Elad Sharon of the National Cancer Institute.
550-plus patients enrolled
It has enrolled more than 550 patients in the U.S. and Canada since it started in 2017. Currently, it’s testing a combo of two immunotherapy drugs, Opdivo and Yervoy — in people grouped into “buckets” according to their tumor type. The drugs’ maker, Bristol-Myers Squibb, is donating them for the study.
One of these buckets just reached critical mass to yield results — neuroendocrine tumors, which can form many places in the body but often in the lungs or digestive tract. Biopsies when the disease is diagnosed classify the cases as high, low or intermediate grade according to how aggressively the cells seem to be growing.
In the study of 32 patients, the drug combo only worked for high-grade tumors. Eight of the 18 patients saw their tumors significantly shrink. None of the others did.
In the high-grade group, survival at six months without worsening disease was 31% — better than the 10% that doctors historically have seen for such patients, said Patel, who has been a paid adviser to Bristol-Myers and several other companies.
Avoiding false hope
“It gives us a glimpse into what can happen,” said another study leader, Dr. Razelle Kurzrock at the San Diego cancer center. “If we get it right, maybe we can get it to work in more patients.”
About one-quarter of all patients had symptoms typical of immune system therapies — effects on the liver, fatigue, nausea — and 6% had colitis, gut inflammation. But side effects were manageable and not severe, Patel said.
Identifying which patients are likely to benefit from these drugs spares others these side effects, expense and false hope.
Sagasser developed a problem from Yervoy, but continues to get Opdivo every two weeks. She is looking forward to next year, when it will be 20 years since she was first diagnosed.
“It will be a party next year, believe me,” she said. “I expect to be cancer-free by then and for good.” (VOA)
A couple of years ago, finding a strand of grey hair meant visiting the parlor to cover it up. Women and men refused to admit their age, and refused to let it show. Be it moustache, eyebrows, or hair on the head, it was dyed a luscious black, or reddish-brown for those who wanted to go natural. Today, the trend of coloring hair has nothing to do with age. Young boys and girls sport bright colors and hairstyles, which is now a marker of how modern one can be.
This notion of modernity associated with neon streaks and an almost gothic look originates from the ancient Egyptian civilization, where it was considered fashionable to look different from the natural features one was born with. Kohl, lipstick, perfume, and makeup were the inventions of those who hoped to live even after death. Likewise, they were the first people to discover hair dye. Initially, they dyed their hair black, to cover the grey. They used compounds that were extracted from plants, but some of them were lethal. So, they took to extracting the color from fermented leeches.
This was when a chemical was discovered to gently lighten hair color instead of completely bleaching it, and since then, there have been varying degrees of blonde and brown hair. Image credit: Photo by Jessie Dee Dabrowski on Unsplash
When bleach was discovered, women used it to achieve a yellow color, which became known as the sign of prostitutes. The focus shifted to naturally red hair when Queen Elizabeth took the throne, as she suffered from a genetic mutation which caused this. Red heads became more common in Scotland and Ireland, and everywhere else, black hair was still the norm.
When William Perkins discovered mauve during an experiment that went wrong, the concept of mixing two or more chemicals together to create a dye became well-known. So colorless chemicals were developed and mixed in varying ratios to dye hair. When the movie Platinum Blonde was released, the trend of having pale hair increased greatly. People began to go blonde everywhere. This was when a chemical was discovered to gently lighten hair color instead of completely bleaching it, and since then, there have been varying degrees of blonde and brown hair.
Youngsters prefer to sport bright, flashy colors, like teal, blue, purple, and even pink. Image credit: Photo by Tom van Kessel on Unsplash
With the arrival of pop-culture and its influence on the world, these mundane colors are reserved for the elderly. Youngsters prefer to sport bright, flashy colors, like teal, blue, purple, and even pink. Every time a new star sports a different color, the trend sparks interest in others, and sweeps across the globe like a wildfire. Hair dye has come a long way since the time of the Egyptians in the first century. Two thousand years hence, it has the potential to grow into so much more.
Keywords: Hair Color, Hair Dye, Egyptians, Perkins, Pop Culture
The history of Daryaganj goes back to the era of Mughal dynasty, and so its history is as old as the old city of Shahjahanabad, now Chandni Chowk. Interestingly, this market was known as Faiz Bazaar in the Mughal era and was considered as an important commercial place.
In fact, at that time this area was very posh, and had beautiful houses on both sides of a stream from a hauz (meaning, water storage tank) flowing down the centre. Not only this, trees were lined up for shade and it looked like a marvellous garden had been turned into a market.
Also, there used to be Lohe ka Pull which used to connect shops lined on both sides of the market starting from Delhi Gate to the Iron Bridge, but now the pull no longer exists. Well, there's no doubt that the old city of Shahjahanabad was beautiful crafted!
One of the most beautiful things about Daryaganj is its famous book market, known as the Sunday Patri Kitaab Bazaar. Sunday is specifically added here because the book market takes place only on Sundays, that, too, from 9am till 6pm.
Booksellers set up their shops on Patri (footpath). Hence, the name is Sunday Patri Kitaab Bazaar. Photo by Flickr.
In this market, you can find all kinds and genres of books at cheapest rates. In fact, some booksellers sell books according to kilos, and this is really astounding to see. From stationery to art supplies, you can find everything here and that, too, in a lot of variety.
It is interesting to see that some of the shopkeepers of Daryaganj book market are selling books from the past 50-60 years. Not only this, Daryaganj book market is also famous for its branded electronic goods and science lab equipments.
Apart from this, you can also find some of the lost traces of British rule, which once existed in India, in this market in the form of coins, photographs, and even their personal belongings. There is absolutely no doubt that Daryaganj book market offers a lot more than books, as it offers glimpses of the past.
So, if you are someone who is not just into books but also colonisation of India, then you must visit Daryaganj book market and experience a mixture of past and present!
Keywords: Daryaganj Book Market, Books, Old Delhi, Chandni Chowk, India, Mughal Dynasty.
Social media is an umbrella term that encompasses all apps, websites, and blogs that allow people from all over the world to interact through the internet. Anyone who wishes to use any social media platform must first sign up and then sign in to view content and communicate with other members of that social media platform. Facebook, Twitter, Instagram, WhatsApp, LinkedIn, and Snapchat are commonly used social media platforms. Social media, like all technological advancements, has both advantages and disadvantages.
Social media has become an essential aspect of life for many youths in today's society. Numerous young people carry on involving themselves with social media without even bothering to consider its effect on them. The consequences may be both good and bad at times. When it comes to the negative impact of social media on teenagers, the majority of the time, they are unfavourable if the activity is not linked with a commercial or professional objective.
Social media has taken on such significance in today's society that it has overtaken other concerns. | Photo by Sara Kurfeß on Unsplash
Social media has taken on such significance in today's society that it has overtaken other concerns. People, especially teens, are addicted to social media and have lost sight of the essential things in their lives like family, friends, physical activities, social interaction, sports, education and much more.
One manner in which social media harms our mental health is through the use of unfavourable social comparisons. Teenagers or even grown-ups who use social media spend a significant amount of time examining the lives and activities of their friends. Continuous comparisons lead to low self-esteem and negative body image in adolescents, increasing depression and anxiety in such people; this includes stalking their achievements, events, their pictures or the events they have attended. On comparing, it makes oneself feel worse about their life.
Teenagers or even grown-ups who use social media spend a significant amount of time examining the lives and activities of their friends. | Photo by Ángel López on Unsplash
We can only see the virtual aspect of a person while we are on social media sites. This means that we can only see the side of the situation that they want us to see. Many people make an effort to present themselves in a way that they are not. Bullying among peers is a common practice, which is acceptable to a certain level. However, when it comes to cyberbullying, it has a significant impact on a person's mental health, as the comments or posts may appear on the newsfeed of any individual and spread quickly. Depression and suicidal behaviour can occur as a result of such things.
Particular teenagers are highly prone to be manipulated. Such teenagers may feel the urge to alter their physical appearance as they begin to compare themselves with every other person they come across on social media. This can result in low-self esteem; also, there is a tremendous temptation to overindulge on social media. Hence, it can become an addiction for adolescents and cause them to get distracted, as already mentioned.
Several studies have found that excessive social media use is frequently associated with underlying problems such as depression, chronic stress, anxiety, or low self-esteem. | Photo by AH NP on Unsplash
Several studies have found that excessive social media use is frequently associated with underlying problems such as depression, chronic stress, anxiety, or low self-esteem. Hence, it becomes a social responsibility for us to keep a check on our and our friends' mental well-being by unplugging our devices, building solid friendships and beginning the search to find our true inner self by meditation, exploring nature and organizing offline get together.
Keywords: negative, unfavourable, friends, depression, teenagers, people, social, mental health