Friday May 24, 2019

Researchers Develop Novel Treatment to Treat Diabetes, Multiple Sclerosis

However, in people with autoimmune disease, these cells somehow escape the checkpoint and the immune system remains in a state of alert, attacking body cells

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Diabetes
Representational image. Pixabay

Researchers have developed a novel and safe treatment for autoimmune diseases including Type-1 diabetes and multiple sclerosis (MS) that arise when the body’s immune cells attack itself.

Current treatments eliminate these misfunctioning immune cells, but also destroy normal, protective immune cells, leaving patients susceptible to immune deficiency and opportunistic infections.

The new approach, by researchers from the University of Utah in the US, targets the misfunctioning immune cells while leaving the normal immune cells in place.

In the study, published in the journal Nature Biomedical Engineering, the team engineered a protein molecule to deplete the misfunctioning PD-1-expressing cells from the body while leaving normal immune cells in place.

“We wanted to target PD-1-expressing cells. Using this method, we may avoid long-term immune deficiency caused by common treatments for autoimmune disease,” said lead author Peng Zhao, from the varsity.

When tested in a mouse model mimicking Type-1 diabetes, the treatment delayed the onset of diabetes.

“We are really taking treatment for autoimmune disease in a new direction,” said Mingnan Chen, Assistant Professor at the varsity.

Diabetes
Representational image. Pixabay

“To make similar therapeutics for people, we would need to find the anti-human PD-1 antibody, like the anti-mouse PD-1 antibody.

“If we can generate the human version of therapeutics, I think we could make a huge impact in treating autoimmune disease,” Chen said.

In addition, the treatment was also applied to a mouse MS model.

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Besides halting the progression of paralysis, the treatment also restored the mice’s ability to walk.

In a normal functioning immune system, the PD-1-expressing cells, including immune cells, contain a mechanism that prevents the cycle from attacking itself.

However, in people with autoimmune disease, these cells somehow escape the checkpoint and the immune system remains in a state of alert, attacking body cells. (IANS)

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Obesity Increasing More Quickly in Rural Areas than in Cities Worldwide: Study

City-dwelling women and men, however, put on 38 and 24 percent less, respectively, than their rural counterparts over the same period, according to the findings, published in Nature

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FILE - A man crosses a main road as pedestrians carrying food walk along the footpath in central Sydney, Australia. VOA

Obesity worldwide is increasing more quickly in rural areas than in cities, a study reported Wednesday, challenging a long-held assumption that the global epidemic of excess weight is mainly an urban problem.

Data covering 200 countries and territories compiled by more than 1,000 researchers showed an average gain of roughly five to six kilos per woman and man living in the countryside from 1985 to 2017.

City-dwelling women and men, however, put on 38 and 24 percent less, respectively, than their rural counterparts over the same period, according to the findings, published in Nature. “The results of this massive global study overturn commonly held perceptions that more people living in cities is the main cause of the global rise in obesity,” said senior author Majid Ezzati, a professor at Imperial College London’s School of Public Health.

“This means that we need to rethink how we tackle this global health problem.” The main exception to the trend was sub-Saharan Africa, where women gained weight more rapidly in cities. Obesity has emerged as a global health epidemic, driving rising rates of heart disease, stroke, diabetes and a host of cancers.

obesity
Two women converse in New York, June 26, 2012. The nation’s obesity epidemic continues to grow, led by an alarming increase among women. Obesity is one of the risk factors of heart failure. VOA

The annual cost of treating related health impacts could top a trillion dollars by 2025, the World Obesity Federation estimated in 2017. To date, most national and international policies to curb excess body weight have focused on cities, including public messaging, the redesign of urban spaces to encourage walking, and subsidized sports facilities.

Body-mass index

To factor health status into the comparison across nations, the researchers used a standard measure known as the “body-mass index”, or BMI, based on height and weight. A person with a BMI of 25 or more is considered overweight, while 30 or higher is obese. A healthy BMI ranges from 18.5 to 24.9.

Approximately two billion adults in the world are overweight, nearly a third of them obese. The number of obese people has tripled since 1975. The study revealed important differences between countries depending on income level.

In high-income nations, for example, the study found that rural BMI were generally already higher in 1985, especially for women. Lower income and education levels, the high cost and limited availability of healthy foods, dependence on vehicles, the phasing out of manual labour — all of these factors likely contributed to progressive weight gain.

Obesity
The populations — both men and women — in small South Pacific island nations have among the highest BMI levels in the world, often well above 30. Pixabay

Conversely, urban areas “provide a wealth of opportunities for better nutrition, more physical exercise and recreation, and overall improved health,” Ezzati said. Around 55 percent of the world’s population live in cities or satellite communities, with that figure set to rise to 68 percent by mid-century, according to the United Nations.

‘Ultra-processed foods’

The most urbanized regions in the world are North America (82 percent), Latin America and the Caribbean (81 percent) and Europe (74 percent). More recently, the proportion of overweight and obese adults in the rural parts of many low- and middle-income countries is also rising more quickly than in cites.

“Rural areas in these countries have begun to resemble urban areas,” Barry Popkin, an expert on global public health at the University of North Carolina, said in a comment, also in Nature. “Modern food supply is now available in combination with cheap mechanized devices for farming and transport,” he added. “Ultra-processed foods are also becoming part of the diets of poor people.”

Obesity
“The NDC Risk Factor Collaboration challenges us to create programmes and policies that are rurally focused to prevent weight gain”, Popkin said. VOA

At a country level, several findings stand out. Some of the largest BMI increases from 1985 to 2017 among men were in China, the United States, Bahrain, Peru and the Dominican Republic, adding an average of 8-9 kilos per adult.

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Women in Egypt and Honduras added — on average, across urban and rural areas — even more. Rural women in Bangladesh, and men living in rural Ethiopia, had the lowest average BMI in 1985, at 17.7 and 18.4 respectively, just under the threshold of healthy weight. Both cohorts were well above that threshold by 2017.

The populations — both men and women — in small South Pacific island nations have among the highest BMI levels in the world, often well above 30. “The NDC Risk Factor Collaboration challenges us to create programmes and policies that are rurally focused to prevent weight gain”, Popkin said. (VOA)