Tuesday January 21, 2020

Researchers Develop Novel Treatment to Treat Diabetes, Multiple Sclerosis

However, in people with autoimmune disease, these cells somehow escape the checkpoint and the immune system remains in a state of alert, attacking body cells

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According to the researchers, these novel findings may provide the basis for new therapies for patients who have heart disease complicated by diabetes. Pixabay

Researchers have developed a novel and safe treatment for autoimmune diseases including Type-1 diabetes and multiple sclerosis (MS) that arise when the body’s immune cells attack itself.

Current treatments eliminate these misfunctioning immune cells, but also destroy normal, protective immune cells, leaving patients susceptible to immune deficiency and opportunistic infections.

The new approach, by researchers from the University of Utah in the US, targets the misfunctioning immune cells while leaving the normal immune cells in place.

In the study, published in the journal Nature Biomedical Engineering, the team engineered a protein molecule to deplete the misfunctioning PD-1-expressing cells from the body while leaving normal immune cells in place.

“We wanted to target PD-1-expressing cells. Using this method, we may avoid long-term immune deficiency caused by common treatments for autoimmune disease,” said lead author Peng Zhao, from the varsity.

When tested in a mouse model mimicking Type-1 diabetes, the treatment delayed the onset of diabetes.

“We are really taking treatment for autoimmune disease in a new direction,” said Mingnan Chen, Assistant Professor at the varsity.

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Representational image. Pixabay

“To make similar therapeutics for people, we would need to find the anti-human PD-1 antibody, like the anti-mouse PD-1 antibody.

“If we can generate the human version of therapeutics, I think we could make a huge impact in treating autoimmune disease,” Chen said.

In addition, the treatment was also applied to a mouse MS model.

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Besides halting the progression of paralysis, the treatment also restored the mice’s ability to walk.

In a normal functioning immune system, the PD-1-expressing cells, including immune cells, contain a mechanism that prevents the cycle from attacking itself.

However, in people with autoimmune disease, these cells somehow escape the checkpoint and the immune system remains in a state of alert, attacking body cells. (IANS)

Next Story

India Registers an Uptick in Diabetes and Thyroid: Report

Uptick in diabetes, thyroid in India in 2019

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India registered an increase in lifestyle diseases including diabetes and thyroid. Pixabay

As India registered an increase in lifestyle diseases including diabetes and thyroid, a new report suggests that women are unhealthier than men, and Chandigarh is the healthiest city while Kolkata unhealthiest city for the second year in a row. This is the latest health news.

As per the GOQii India Fit Report 2020, diabetes has increased from 7.1 to 12 per cent this year.

“The incidence of diabetes is highest among older adults at 23.81 per cent and seniors at 36.82 per cent. As per the report, 13.5 per cent of Indians have cholesterol issues.

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Diabetes has increased from 7.1 to 12 per cent this year. Pixabay

“Currently 36 per cent of the people who have high cholesterol have heart issues too while 51.7 per cent of the people who have diabetes have abnormal cholesterol too. This past year, thyroid issues have increased from 6.8 to 10.7 per cent. The report also suggests that 13.4 per cent of the people in India have high blood pressure,” GOQii, a smart-tech enabled preventive healthcare platform, said.

As per the report, 27 per cent of India has acidity and indigestion issues.

Speaking city-wise, 18 per cent people in Kolkata are diabetic followed by Surat and Bhopal. Kolkata also has the largest aging population in the country, the most people with acidity, and the highest incidence of lifestyle diseases, while Bhopal has the highest percentage of people who consume alcohol.

The report has collected data from a cross-section of 5 million GOQii app users across 16 cities.

Interestingly, it also took the study of longevity under its ambit, and reveals what some of India’s oldest people attribute their longevity to.

Turns out, the secret to a long life is – eating nutritious food, staying active, socializing and sound sleep. These attributes were the common contributing factors for leading a long and healthy life according to 90-year olds and centenarians.

Also Read- Prenatal Smoking, Drinking Increases SIDS Risk; Says New Study

The elderly people also believed that eating home-cooked and fresh, local and seasonal vegetarian meals at fixed and regular intervals played an important role in their day-to-day regimen. Dairy, especially milk, curd and ghee emerged as kitchen superheroes for this age group.

The centurions also believed that having a hobby, being social and content enhanced the quality of their lives. (IANS)