Friday, August 7, 2020
Home Life Style Health & Fitness 'Trojan Horse' Antibody Strategy Shows Promise Against Ebola Virus

‘Trojan Horse’ Antibody Strategy Shows Promise Against Ebola Virus

Monoclonal antibodies, which bind to and neutralize specific pathogens and toxins, have emerged as the most promising treatments for Ebola

Scientists have found a hidden weak spot shared by all five known types of the deadly Ebola virus and successfully targeted it with two antibodies that blocked its ability to invade human cells.

In early-stage laboratory experiments published in the journal Science, the researchers developed a “Trojan horse” strategy that allows engineered antibodies to hitch a ride on Ebola to where the virus is most vulnerable before hitting it.

Follow NewsGram on Twitter

“The success in co-opting the virus itself to dispatch a lethal weapon … marks a turning point in the development of smart therapeutics against infectious diseases,” said M. Javad Aman, a scientist, and president at the U.S. biotech firm Integrated Bio Therapeutics who worked on the team.

Although years of testing lie ahead before any fully approved treatment might be developed for Ebola patients, Aman said similar strategies could also be devised against several other viral and bacterial pathogens.

No approved treatments

Ebola is an extremely deadly and contagious disease for which there are currently no regulator-approved vaccines or treatments. A vast outbreak of the Zaire strain of the virus, which causes haemorrhagic fever, killed more than 11,000 people and infected around 29,000 in West Africa in 2014-15.

Monoclonal antibodies, which bind to and neutralize specific pathogens and toxins, have emerged as the most promising treatments for Ebola. But a critical problem is that most antibody therapies — including the most promising experimental therapy, ZMapp — target only one specific Ebola virus.

Ebola Virus. Image Source: Wikimedia Commons.
Ebola Virus. Image Source: Wikimedia Commons

Follow NewsGram on Facebook

In this work, the research team found a way around this by targeting a weak spot — in the so-called lysosome of the cell — to where antibodies could hitch a ride on Ebola and deliver a punch that blocked the virus’ exit and ability to replicate.

The strategy could eventually be developed for use in a range of other viruses, the scientists said, including cousins of Ebola such as Marburg, and other viral diseases such as dengue or Lassa.

“It’s impossible to predict where the next Ebola virus outbreak will occur or which virus will cause it,” said Jon Lai of the Albert Einstein College of Medicine in New York City, who co-led the work. “We hope that further testing in nonhuman primates will establish our antibodies as safe and effective for treating those exposed to any Ebola virus.”(VOA)

STAY CONNECTED

18,959FansLike
362FollowersFollow
1,781FollowersFollow

Most Popular

Inclusivity: A Matter of Survival for Brands

By Puja Gupta Indian men are becoming increasingly self-aware and skin-care is losing its retrograde 'girly' tag. Men are investing in grooming products and going...

Chromotherapy: Heal Physiological, Psychological Imbalances in the Body Through Colours

By Puja Gupta Colours are part of the natural world and they play a major role in a way we feel and react in various...

Helpless, Desperate Pakistani Hindus Convert to Islam to Overcome Troubles

(Editorial Note- The views expressed in this article have been shared from an article published at The New York Times) The lips of Hindus stumbled...

Priyanka Chopra is Being Extra Cautious During Covid Pandemic

Priyanka Chopra and Nick Jonas are being extra cautious during the Covid pandemic. Priyanka opened up on how the couple is coping during the global...

Smoking Linked to Higher Risk of Bone Fracture

Smoking has been linked to a higher risk of bone fracture, but researchers have now identified certain lung-related factors -- such as smoking or...

Gajraj Rao: OTT is Playing Good, Important Role for Content-Driven Films

Actor Gajraj Rao feels the web has emerged as an important platform for content-driven shows and films but to get the right impact for...

Microsoft Announces New Platform to Help Indian Firms Return to Work

Microsoft on Thursday announced the general availability of its Power Platform Return to the Workplace solution in India to help organisations prepare for the...

NYC Celebrates Ram Mandir Bhumi Pujan Despite Ban on Video Display

By Arul Louis Hindus and their supporters in New York City celebrated the laying of the foundation stone for the Ram temple in Ayodhya, ignoring...

Recent Comments