Monday February 18, 2019
Home Lead Story Tuberculosis ...

Tuberculosis A Vicious Epidemic: Deputy UN Chief

The WHO released its annual TB report. It found cases in all countries and among all age groups.

0
//
hospitals
Chronic doctor shortage affecting Delhi government-run hospitals. VOA

Tuberculosis (TB) is a vicious epidemic that is drastically underfunded. That was the takeaway message from the first high-level meeting focused on the infectious disease at the U.N. General Assembly in New York.

Amina Mohammad, U.N. deputy secretary-general, said the disease is fueled by poverty, inequality, migration and conflict, and that an additional $13 billion per year is needed to get the disease under control.

Last year, tuberculosis killed more people than any other communicable disease — more than 1.3 million men, women and children.

The World Health Organization estimates that the 10 million people who become newly infected each year live mostly in poor countries with limited access to health care.

TB
The Bacteria that causes Tuberculosis

Dr. Tedros Adhanom Ghebreyesus, head of the WHO, told the assembly that partnership is vital to end the disease. He said the WHO is committed to working with every country, partner and community to get the job done.

The WHO plans to lead U.N. efforts to support governments and other partners in order to drive a faster response to TB.

Most people can be cured with a six-month treatment program. But as world leaders told the assembly, medication is expensive, and the stigma associated with TB interferes with getting people screened and treated.

Nandita Venkatesan, a young woman from India, told the assembly about the toll the disease has taken on her life. She got TB more than once, including a drug-resistant variety. She said it robbed her of eight years of her life while she was being treated. One of the medications she took to help cure TB robbed her of her hearing.

TB
Amina Mohammad, U.N. deputy secretary-general, said the disease is fueled by poverty, inequality, migration and conflict, Pixabay

Venkatesan said getting cured involved hospital stays, six surgeries and negative reactions to at least one drug used to cure her.

Also Read: Statistics of Babies Born With Syphilis Dobles Since 2013

Just days before the high-level meeting, the WHO released its annual TB report. It found cases in all countries and among all age groups. It also found that two-thirds of the cases were in eight countries — India, Pakistan, Bangladesh, China, Indonesia, the Philippines, South Africa and Nigeria.

The meeting ended with the adoption of a declaration intended to strengthen action and investments for ending TB and saving millions of lives. (VOA)

Next Story

Novel Drug May Shorten Treatment Duration For Tuberculosis

Despite significant progress in combating tuberculosis, it remains the leading infectious cause of death worldwide, he said

0

A new experimental antibiotic for tuberculosis (TB) has been shown to be more effective against TB than Isoniazid, a decades old drug which is currently one of the standard treatment for the disease, finds a study on mice.

The new drug, called AN12855, has several advantages over Isoniazid as Isoniazid requires conversion to its active form by a Mycobacterial enzyme, KatG, in order to kill the pathogen, which creates some problems.

In some M. tuberculosis, KatG is nonfunctional. That does not make M. tuberculosis any less pathogenic, but it prevents the drug from working. Consequently, this creates an easy avenue for the development of drug resistance.

In the study, the new drug showed a much lower tendency to develop resistance, and it remains in the tissues where the Mycobacterium tuberculosis bacteria reside for longer, killing them more effectively.

WHO will start working towards ending Tuberculosis
Dr. Simon Angelo (L) examines Iman Steven suffering from tuberculosis, held by her mother (R) at the hospital of Doctors Without Borders (MSF), June 15, 2016, at the Protection of Civilians (PoC) site in Malakal, South Sudan. VOA

The goal of TB drug development programmes is to develop universal treatment regimens that will shorten and simplify TB treatment in patients, which typically takes at least six months, and sometimes more than a year, said lead author Gregory T. Robertson, Assistant Professor at the Colorado State University in Fort Collins in the US.

For the study, the researchers used a new TB mouse model that develops these M. tuberculosis-containing granulomas to compare Isoniazid and AN12855.

Granuloma refers to a mass of granulation tissue, typically produced in response to infection, inflammation, or the presence of a foreign substance.

“We discovered that the drugs differed dramatically with respect to their abilities to kill the pathogen in highly diseased tissues,” said Robertson.

Tuberculosis
New TB drug may shorten treatment duration: Study. IANS

AN12855 proved more effective, “without selecting for appreciable drug resistance”, added Robertson in the study published in the journal Antimicrobial Agents and Chemotherapy.

Despite significant progress in combating tuberculosis, it remains the leading infectious cause of death worldwide, he said.

Also Read- Oscar Nominees Furious Over Exclusion From Telecast

“Multidrug resistance is a further challenge to the mission to control TB globally. Collectively, our group has pioneered the use of new TB mouse efficacy models to help advance innovative new therapies designed to shorten the length of TB treatment.” (IANS)