Tuesday October 15, 2019

Here’s How Turmeric Helps Heart Failure Patients

The results showed that the expression of Nrf2 increased and levels of antioxidant enzymes improved in the animals with heart failure that were given curcumin

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Indian-American researchers unleash turmeric's power to fight cancer
How turmeric helps heart failure patients? Find it out here. Pixabay

Curcumin — the active compound in turmeric — may repair exercise intolerance faced by patients with heart failure, suggests a new research.

People with heart failure have a reduced function of the left ventricle — the chamber of the heart that pumps blood out to the rest of the body — called reduced ejection fraction. This is linked to decreased ability to exercise.

The findings showed that curcumin treatment improved muscle function, exercise capacity in mice with heart failure and healthy controls.

Curcumin, a chemical that comes from the turmeric plant, has been used as a traditional Asian medicine for centuries, primarily to treat gastrointestinal ailments and skin wounds.

Researchers from the University of Nebraska in the US, theorised that a reduction in the normal signalling of a protein Nrf2 may play a role in the impaired expression of antioxidant enzymes.

 

Healthy Indian foods
Turmeric (Wikimedia)

The antioxidant enzymes both prevent and repair damage from oxidative stress as well as improve exercise performance.

For the study, published in the Journal of Applied Physiology, the team gave one group of mice with heart failure daily doses of curcumin — which is known to promote activation of Nrf2 — for 12 weeks, while another group did not receive treatment.

The results showed that the expression of Nrf2 increased and levels of antioxidant enzymes improved in the animals with heart failure that were given curcumin.

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In addition, both groups that received curcumin — even the animals without heart failure — had improved exercise capacity when compared with the untreated groups, suggesting the effects of curcumin on skeletal muscle is not exclusive to heart failure.

“These data suggest that activation of Nrf2 in skeletal muscle may represent a novel therapeutic strategy to improve … quality of life” in people with heart failure with reduced ejection fraction, the researchers noted. (IANS)

Next Story

Researchers Identify Genes Linked to the Risk of Heart Failure

"That understanding of the genetic basis of heart structure and function in the general population improves our knowledge of how heart failure evolves," said study researcher Steffen Petersen

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genes, heart failure
The heart attack brings about activation of certain genes which stay as a permanent memory in genes. Pixabay

Researchers have found the way for earlier identification of people at risk of heart failure and development of new treatments.

The research team applied an artificial intelligence (AI) technique to analyse the heart MRI images of 17,000 healthy UK Biobank volunteers and found that genetic factors accounted for 22-39 per cent of variation in the size and function of the heart”s left ventricle, the organ”s main pumping chamber.

Enlargement and reduced pumping function of the left ventricle can lead to heart failure, the study said.

“It is exciting that the state-of-the-art AI techniques now allow rapid and accurate measurement of the tens of thousands of heart MRI images required for genetic studies,” said study lead researcher Nay Aung from Queen Mary University of London.

“The findings open up the possibility of earlier identification of those at risk of heart failure and of new targeted treatments,” Aung said.

“Heart failure is preventable and treatable,” Fonarow said. “There is an urgent need to eliminate the healthcare policy that has been associated with the increase in heart failure deaths. Pixabay

The research, published journal Circulation, suggests that genetic factors significantly influence the variation in heart structure and function.

The team identified 14 regions in the human genome associated with the size and function of the left ventricle – each containing genes that regulate the early development of heart chambers and the contraction of heart muscle.

Previous studies have shown that differences in the size and function of the heart are partly influenced by genes but the researchers have not really understood the extent of that genetic influence.

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This study has shown that several genes known to be important in heart failure also appear to regulate the heart size and function in healthy people.

“That understanding of the genetic basis of heart structure and function in the general population improves our knowledge of how heart failure evolves,” said study researcher Steffen Petersen. (IANS)