Tuesday June 18, 2019

Here’s How Turmeric Helps Heart Failure Patients

The results showed that the expression of Nrf2 increased and levels of antioxidant enzymes improved in the animals with heart failure that were given curcumin

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Indian-American researchers unleash turmeric's power to fight cancer
How turmeric helps heart failure patients? Find it out here. Pixabay

Curcumin — the active compound in turmeric — may repair exercise intolerance faced by patients with heart failure, suggests a new research.

People with heart failure have a reduced function of the left ventricle — the chamber of the heart that pumps blood out to the rest of the body — called reduced ejection fraction. This is linked to decreased ability to exercise.

The findings showed that curcumin treatment improved muscle function, exercise capacity in mice with heart failure and healthy controls.

Curcumin, a chemical that comes from the turmeric plant, has been used as a traditional Asian medicine for centuries, primarily to treat gastrointestinal ailments and skin wounds.

Researchers from the University of Nebraska in the US, theorised that a reduction in the normal signalling of a protein Nrf2 may play a role in the impaired expression of antioxidant enzymes.

 

Healthy Indian foods
Turmeric (Wikimedia)

The antioxidant enzymes both prevent and repair damage from oxidative stress as well as improve exercise performance.

For the study, published in the Journal of Applied Physiology, the team gave one group of mice with heart failure daily doses of curcumin — which is known to promote activation of Nrf2 — for 12 weeks, while another group did not receive treatment.

The results showed that the expression of Nrf2 increased and levels of antioxidant enzymes improved in the animals with heart failure that were given curcumin.

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In addition, both groups that received curcumin — even the animals without heart failure — had improved exercise capacity when compared with the untreated groups, suggesting the effects of curcumin on skeletal muscle is not exclusive to heart failure.

“These data suggest that activation of Nrf2 in skeletal muscle may represent a novel therapeutic strategy to improve … quality of life” in people with heart failure with reduced ejection fraction, the researchers noted. (IANS)

Next Story

FDA Approves Device to Treat Heart Failure Patients

The health body has granted approval of the Optimizer Smart system to US-based Impulse Dynamics

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The US Food and Drug Administration has given approval for a new device that would help treat patients with life-threatening heart failure, and address an unmet need in patients who fail to get adequate benefits from standard treatments and have no alternative treatment options.

The Optimizer Smart system is comprised of several components, including an implantable pulse generator, battery charger, programmer and software. The pulse generator is implanted under the skin in the upper left or right area of the chest and connected to three leads that are implanted in the heart.

After the device is implanted, a physician tests and programmes the device, which delivers electrical impulses to the heart during regular heartbeats to help improve the heart’s squeezing capability.

The device would be beneficial for patients not suited to treatment with other heart failure devices such as cardiac resynchronisation therapy to restore a normal timing pattern of the heartbeat, the US FDA noted in a statement.

“Patients with moderate-to-severe chronic heart failure have limited treatment options. And for those who are unable to be treated due to underlying conditions or who have not responded to available treatments, their quality of life may be impacted, with limits on the types of physical activities they can do,” said Bram Zuckerman, Director at FDA’s Centre for Devices and Radiological Health.

Photo Credit: www.medscape.com

“The FDA recognised the unmet need for these patients and worked with the manufacturer…to efficiently bring this product to market, while ensuring it meets our regulatory requirements for safety and effectiveness,” Zuckerman added.

For the study, the US FDA evaluated data from two clinical trials with a total of 389 patients with moderate-to-severe heart failure.

All patients received optimal medical therapy and 191 patients also received an Optimizer Smart system implant.

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The Optimizer Smart system improves quality of life and functional status of certain heart failure patients.

The health body has granted approval of the Optimizer Smart system to US-based Impulse Dynamics. (IANS)