Wednesday November 22, 2017
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Turmeric inspires discovery of anti-cancer molecules

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source: myelomacrowd.org

Bhopal: A state-run university in Bhopal discovered anti-cancer molecules after being inspired by the healing properties of turmeric, which have been tried and tested for generations. This breakthrough is a revolutionary way forward in cancer treatment.

The Rajiv Gandhi Proudyogiki Vishwavidyalaya (RGPV) has also applied for a US patent of the discovery of the anti-cancer molecules code-named CTR-17 and CTR-20, informed Vice Chancellor Piyush Trivedi and his doctoral student Dr C Karthikeyan to news agencies on Monday.

“Inspired by the healing properties of turmeric, which is available in every household and considered as an effective antiseptic and given almost to everyone for treating various ailments, we have studied it deeply for almost 10 long years and discovered a molecule based on our findings which has magical effects on treating cancer during pre-clinical trials,” said Trivedi.

He added that this molecule only targets cancerous cells without damaging the others. So, unlike chemotherapy, the process had no side effects.

“The molecules code named CTR-17 and CTR-20 elicits anticancer activity through a mechanism which involves obstruction of cancer cell division by inhibition of tubulin, a protein which is important for many important cellular functions, including chromosome segregation during cell division, intracellular transport, development and maintenance of cell shape, cell motility and distribution of molecules on cell membranes,” explained Karthikeyan, who was a part of the research since the beginning.

Trivedi added that 22 other molecules had also been discovered, which produced good results in clinical trials, and would be a blessing for cancer patients.

The research was carried out in collaboration with Canada-based Advanced Medical Research Institute’s Dr Hyoun Lee’s team. After pre-clinical trials, the clinical trials are also slated to be held there on mice.

“Studies in the lab have also showed that CTR-17 and CTR-20 increased the life span of animals affected with tumour manifold by including tumour regression in mice models without showing any long-term adverse effects, especially less toxicity,” said Trivedi.

Furthermore, if combined with another anti-cancer drug in clinical use – ‘paclitaxel’, a strong synergistic effect is seen. Alone or combined, the molecules have shown strong anti-tumour activity.

“This is a significant discovery especially in the present context when cancer has become world’s dreaded killer disease accounting for 8.2 million deaths (around 13 per cent of all deaths) in 2012 as per the World Cancer Report and scientists embattling cancer are on the lookout for newer effective and safer drugs for anticancer therapy,” Trivedi added.

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Glow Your Skin This Festive Season with These Homemade Face Packs

Makeup expert Shahnaz Husain have listed some DIY face packs

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face packs
Face Pack Treatment. Pixabay

New Delhi, Sep 21, 2017: Nothing can beat the goodness of homemade face masks which are made from natural ingredients like bananas, papayas, oats, aloe vera, honey, turmeric and more. With the festive season around the corner, experts suggest shakes, flower mixes and face packs which can be easily made at home.

Gunjan Gaur, make-up expert at ALPS Cosmetic Clinic and make-up expert Shahnaz Husain, have listed some useful face pack recipes:

* Honey banana face mask: Mash half a ripe banana and milk, one table spoon of sandalwood powder paste and half table spoon of honey. Let it stay on your skin for 20-25 minutes and wash it with lukewarm water. This face mask is beneficial for oily skin as sandalwood helps in cleansing excess sebum and oil from the skin while banana keeps it moisturised.

* Make a cold infusion of Hibiscus flowers, by allowing them to stand overnight in cold water, in a ratio of one to six. Next morning crush the flowers. Strain and keep the water. Mix the flowers with 3 teaspoons oats, two drops tea tree oil and add the water to mix into a paste. This hibiscus pack helps to cleanse, refresh and tone the skin, adding a glow.

* Take honey and yogurt and add a few tablespoons of red wine. Apply this on the face and leave it on for 20 minutes. Rinse with plain water. This softens and moisturizes the skin, removes tan and also adds a glow.

Also Read: Skin Benefits Of Coconut Oil: Beauty Tips using Coconut Oil 

* Avocado pulp can be mixed with aloe vera gel and applied on the face to nourish and moisturise the skin. Wash off with plain water after 20 minutes. Fresh and raw avocado should be used. Avocado contains about 20 vitamins and minerals. It is rich in antioxidants, which help to delay skin ageing.

* Kiwi juice: Peel kiwi and cut into slices. Keep empty container under juice extractor nozzle and process apple, celery and kiwi fruit slices through the juicer. Discard the fibrous pulp.

* Apple Halwa: Peel the apples. Cut into slices and run them into a food processor till the apples are well grinded. In a pan heat ghee, add the apples. Now add sugar and mix, till the sugar melts. The halwa will again become liquidly. Garnish with sliced almond and serve.

* Watermelon smoothie: Blend watermelon, mango, sugar and water together in a blender until smooth. Place ice into glasses and pour smoothie over ice.

* Orange jelly: Natural orange jelly, place the water and sugar in a saucepan over a low heat and stir, until the sugar dissolves. Sprinkle the gelatin over the surface of the water and stir in until dissolved. Remove from the heat and add the orange juice. Decorate with blueberries and mint leaves.

* Mix cucumber and ripe papaya pulp with curd and two teaspoons oats. Lemon juice can also be added. Apply on face and neck. Wash it off after half an hour. Helps to remove tan and brighten the skin.

* For oily skin, soak one tablespoon moong dal in water for a few hours. Make a paste and add one tablespoon tomato pulp. Apply on face with a light massage. Wash off with water after 20 minutes. the pack reduces oiliness and brightens the skin. (IANS)

 

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Melatonin May Help Treat Blood Cancers like Leukemia and Lymphoma, Claims a New Research

The researchers have noted that the anti-cancer actions of melatonin will be helpful in facilitating clinical applications and basic research

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Melatonin produced by a gland in the brain can help treat blood cancers
Melatonin may help treat blood cancers. Pixabay
  • Researchers have discovered that Melatonin may help treat blood cancers like leukemia and lymphoma 
  • Melatonin’s involvement in regulation of circadian rhythms may help in coordination and synchronization of internal body functions 
  • Anti-cancer actions of melatonin are expected to be helpful in facilitating basic research 

Washington D.C. [USA], September 3, 2017: Researchers have discovered that blood cancers such as leukemia and lymphoma may be treated with a hormone produced by a small gland in the brain.

Melatonin, a hormone produced by a small gland in the brain may be able to treat blood cancers like leukemia and lymphoma, according to the researchers.

The findings suggest that melatonin performs a number of tasks such as boosting the immune response against cancer cells, inhibiting the growth of cancer cells and even protecting the healthy cells from chemotherapy’s toxic effects.

Melatonin’s involvement in regulation of circadian rhythms may help in the coordination and synchronization of internal body functions. The timings of he melatonin treatment may be grave in regard to their anti-cancer effects.

Senior author Yang Yang hopes that this information would prove helpful in the design of studies concerned with the therapeutic efficiency of melatonin in blood cancers.

Also read: Arthritis drug could cure blood cancer: Researchers

The researchers have noted that the anti-cancer actions of melatonin will be helpful in facilitating clinical applications and basic research.

The study has appeared in British Journal of Pharmacology.

-prepared by Samiksha Goel of NewsGram. Twitter @goel_samiksha

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Renowned Scientist Dr. Pushpa Mitra Bhargava Expires at his Prashant Nagar Residence in Uppal

This Indian scientist was internationally identified as a thinker, institution builder, and molecular biologist

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Science
Dr Pushpa Mitra Bhargava expired on Tuesday. Twitter
  • Dr. Pushpa Mitra Bhargava died on Tuesday after a brief illness
  • He was born in Ajmer on February 22, 1928, and had completed his Ph. D. from Lucknow University
  • He was internationally recognized as an institution builder, molecular biologist, and thinker.

Hyderabad, August 2, 2017: Pushpa Mitra Bhargava, the founder and director of the Centre for Cellular and Molecular Biology (CCMB) and a top Indian scientist died due to a brief illness on Tuesday.

As per his family members, Bhargava took his last breath at his Prashant Nagar residence in Uppal. He was 89 years-old and had a son and a daughter.

He was born on February 22, 1928, in Ajmer, and had completed his Ph. D. in synthetic chemistry from Lucknow University. Bhargava in 1953 went to the USA and filled in at the post of a project associate at a lab for research on cancer. He had a dynamic part in the revelation of 5-fluorouracil, which is an anti-cancer medication. He was employed at various research organizations in France and the United Kingdom. He had restricted the endorsement of GM in India and asked for a ban of no less than 15 years on hereditarily altered yields in the nation.

Also read: Indian Origin Scientist Part of Team that developed Asteroid flyby to help NASA test Global Tracking Network

His efforts and vision gave rise to the establishment of CCMB in 1977, an institute for basic biology research and seeking its application for the betterment of society.

The staff of CCMB expressed their condolence and profound sadness at his demise. He was a part of the production of nation building scientists who established Indian science. This Indian scientist was recognized as an institution builder, molecular biologist, and thinker at an international level.

His concerns and engagements covered art and culture as well as science and their link to society. He remained immensely engrossed in social issues, especially those related to the effect of science on society in India and the world. His extraordinary commitment and energy will continue to always motivate scientists in future ventures, said an official press release.

Bhargava is also the receiver of more than 100 national and international awards, including the Padma Bhushan, which is the third highest civilian award of the nation in 1986.  He was amid 100 scientists who had conveyed distress over “the ways in which science and reason were getting eroded” and “climate of intolerance” in a statement.

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Bhargava had communicated worry over “RSS people” going to a meeting of Council of Scientific and Industrial Research (CSIR) labs. He had cautioned that if the present pattern proceeded, India would not remain a democracy and turn into a theocratic nation like Pakistan.

He had additionally blamed Narendra Modi for expressing that India had known the procedure of organ transplantation long back at Indian Science Congress.

-prepared by Harsimran Kaur of NewsGram. Twitter: @Hkaur1025