Friday December 14, 2018
Home Uncategorized Turmeric insp...

Turmeric inspires discovery of anti-cancer molecules

0
//
source: myelomacrowd.org
Republish
Reprint

Bhopal: A state-run university in Bhopal discovered anti-cancer molecules after being inspired by the healing properties of turmeric, which have been tried and tested for generations. This breakthrough is a revolutionary way forward in cancer treatment.

The Rajiv Gandhi Proudyogiki Vishwavidyalaya (RGPV) has also applied for a US patent of the discovery of the anti-cancer molecules code-named CTR-17 and CTR-20, informed Vice Chancellor Piyush Trivedi and his doctoral student Dr C Karthikeyan to news agencies on Monday.

“Inspired by the healing properties of turmeric, which is available in every household and considered as an effective antiseptic and given almost to everyone for treating various ailments, we have studied it deeply for almost 10 long years and discovered a molecule based on our findings which has magical effects on treating cancer during pre-clinical trials,” said Trivedi.

He added that this molecule only targets cancerous cells without damaging the others. So, unlike chemotherapy, the process had no side effects.

“The molecules code named CTR-17 and CTR-20 elicits anticancer activity through a mechanism which involves obstruction of cancer cell division by inhibition of tubulin, a protein which is important for many important cellular functions, including chromosome segregation during cell division, intracellular transport, development and maintenance of cell shape, cell motility and distribution of molecules on cell membranes,” explained Karthikeyan, who was a part of the research since the beginning.

Trivedi added that 22 other molecules had also been discovered, which produced good results in clinical trials, and would be a blessing for cancer patients.

The research was carried out in collaboration with Canada-based Advanced Medical Research Institute’s Dr Hyoun Lee’s team. After pre-clinical trials, the clinical trials are also slated to be held there on mice.

“Studies in the lab have also showed that CTR-17 and CTR-20 increased the life span of animals affected with tumour manifold by including tumour regression in mice models without showing any long-term adverse effects, especially less toxicity,” said Trivedi.

Furthermore, if combined with another anti-cancer drug in clinical use – ‘paclitaxel’, a strong synergistic effect is seen. Alone or combined, the molecules have shown strong anti-tumour activity.

“This is a significant discovery especially in the present context when cancer has become world’s dreaded killer disease accounting for 8.2 million deaths (around 13 per cent of all deaths) in 2012 as per the World Cancer Report and scientists embattling cancer are on the lookout for newer effective and safer drugs for anticancer therapy,” Trivedi added.

Click here for reuse options!
Copyright 2015 NewsGram

Next Story

Here’s How Turmeric Helps Heart Failure Patients

The results showed that the expression of Nrf2 increased and levels of antioxidant enzymes improved in the animals with heart failure that were given curcumin

0
Indian-American researchers unleash turmeric's power to fight cancer
How turmeric helps heart failure patients? Find it out here. Pixabay

Curcumin — the active compound in turmeric — may repair exercise intolerance faced by patients with heart failure, suggests a new research.

People with heart failure have a reduced function of the left ventricle — the chamber of the heart that pumps blood out to the rest of the body — called reduced ejection fraction. This is linked to decreased ability to exercise.

The findings showed that curcumin treatment improved muscle function, exercise capacity in mice with heart failure and healthy controls.

Curcumin, a chemical that comes from the turmeric plant, has been used as a traditional Asian medicine for centuries, primarily to treat gastrointestinal ailments and skin wounds.

Researchers from the University of Nebraska in the US, theorised that a reduction in the normal signalling of a protein Nrf2 may play a role in the impaired expression of antioxidant enzymes.

 

Healthy Indian foods
Turmeric (Wikimedia)

The antioxidant enzymes both prevent and repair damage from oxidative stress as well as improve exercise performance.

For the study, published in the Journal of Applied Physiology, the team gave one group of mice with heart failure daily doses of curcumin — which is known to promote activation of Nrf2 — for 12 weeks, while another group did not receive treatment.

The results showed that the expression of Nrf2 increased and levels of antioxidant enzymes improved in the animals with heart failure that were given curcumin.

Also Read- Google Will Now Power Advertising For Disney

In addition, both groups that received curcumin — even the animals without heart failure — had improved exercise capacity when compared with the untreated groups, suggesting the effects of curcumin on skeletal muscle is not exclusive to heart failure.

“These data suggest that activation of Nrf2 in skeletal muscle may represent a novel therapeutic strategy to improve … quality of life” in people with heart failure with reduced ejection fraction, the researchers noted. (IANS)