Never miss a story

Get subscribed to our newsletter


Two drug trials may promise some relief for people who suffer from migraine headaches as well as those who have cluster headaches, a rare but intensely painful type of headache thought to be related to migraine.

According to a study in The New England Journal of Medicine, two injections of the drug galcanezumab reduced the frequency of episodic cluster headaches (ECH). And in a separate study in the same issue of the journal, an experimental oral drug made migraine pain quickly go away for one in five sufferers.

Cluster headaches typically appear at least once a day — often at the same time of the day or night — for weeks or months. The pain is typically around one eye. They eventually go away for a while but can return after an absence of months or years.

In the galcanezumab study, 106 volunteers received two injections of the anti-migraine medicine or a placebo, spaced one month apart. The drug cut the average number of episodic cluster headaches by 51% during the first three weeks of treatment, from 17.8 per week down to 9.1 per week. Placebo injections produced a 30% reduction, from 17.3 per week to 12.1 per week.

Two drug trials may promise some relief for people who suffer from migraine headaches as well as those who have cluster headaches. PIxabay

Relief for many

Almost three-quarters of participants saw some reduction in headache frequency compared with about half of those on placebo.

“Some patients get completely suppressed and many partially so,” lead author Dr. Peter Goadsby of King’s College London told Reuters Health in an email. “I do not think one can overstate how bad a cluster attack is.”

To be eligible for the study, patients had to have at least one attack every other day but not more than eight per day. The typical volunteer had been dealing with the headaches for more than 16 years. The average age was about 46 years old and more than 82% were men.

Also Read- Google Maps to Now Give Indian Users Dining Offers

Each 300 mg injection costs about $1,400, according to the website Galcanezumab is sold under the brand name Emgality by Eli Lilly, and the company paid for the study.

“Patients report ECH attacks as the most severe pain they experience, bar none,” including childbirth and kidney stones, said Goadsby, director of the NIHR-Wellcome Trust King’s Clinical Research Facility and SLaM Biomedical Research Centre.

“Imagine what it’s like to give birth one to eight times a day, every day, for eight to 12 weeks a year. Imagine not a single full night’s sleep for eight to 12 weeks and you know next year it will be the same,” he said. “This development is really important for these patients.”

And it may spark the development of treatments that are even more effective, he added.

According to a study in The New England Journal of Medicine, two injections of the drug galcanezumab reduced the frequency of episodic cluster headaches (ECH). PIxabay

The U.S. Food and Drug Administration approved the drug as a first-ever treatment for episodic cluster headaches in June. The company estimates that about 250,000 people in the United States suffer from them.

For many, a migraine per month

In contrast, migraine headaches plague about 39 million people in the U.S., primarily women. Three-quarters of people who have migraines experience at least one per month.

The migraine study looked at Biohaven Pharmaceuticals’ experimental oral drug rimegepant, and was financed by Biohaven.

Also Read- Scientists Develop AI Tool to Detect Racial, Gender Discrimination

Researchers found that 19.6% of the 537 volunteers who took it while suffering from a migraine were free of pain within two hours compared with 12% of the 535 volunteers given placebos.

Half the patients in both groups had their pain relapse two to 48 hours after the dose. Unlike conventional treatment with triptan drugs, taking a second dose doesn’t provide additional relief, lead author Dr. Richard Lipton, director of the Montefiore Headache Center in New York City, told Reuters Health in a telephone interview.

“Triptans are well-established therapies; maybe 25% of people with migraines are currently on a triptan,” said Lipton, who is also in the department of neurology at the Albert Einstein College of Medicine. “If it works well for them, they’re not going to be candidates on this drug. This is for people with contraindications for a triptan” or people who get no relief from triptans.

Triptan therapy costs about $7,000 a year, he said, and when it comes to rimegepant, “I’m very hopeful the drug will be affordable because there are a lot of people who need it.” (VOA)



Sports betting has become increasingly popular among the youth in recent times

Sports betting has been around for centuries for the audience to not only watch the sport but to get more deeply involved in the match. It is a fun and often profitable activity for the viewer to win some extra fortune or simply get some extra sweat while watching the game. At first glance, sports betting may look like it's pure luck, but when you indulge deeper into the activity you realize it is more of a calculative and research activity than just pure luck. We must note that yes, luck does play a certain role to some extend but a win is not completely dependent on luck, if you're putting your bets on a certain team you have to make sure to do some research about the players on the team, history of wins and losses of the team and compare the probability of winning and then place bets.

Even though sports betting has existed since the ancient era, it was not until recently that it became increasingly popular among the youth. This happened due to the legalization of the activity and the rise of online sports betting. The technological revolution has expanded the sports betting industry, offering the bettors new markets and ways to bet. The only major difference between online bookmarkers and traditional brick-and-mortar venues of sports betting is that now you can place bets online from your mobile devices, laptops, computers etc.

Keep Reading Show less

The government of Assam has recently consented to translate the research-based book by- Shri Salil Gewali titled "Great Minds on India"

It is indeed good news that the book showcasing the wisdom of India in the eyes of Western intellectuals is getting due recognition and appreciation from other states and abroad. After Karnataka and Punjab, the Government of Assam has recently consented to translate the research-based book by Shillong-based author - Shri Salil Gewali titled "Great Minds on India". The Chief Minister of Assam - Shri Himanta Biswa Sarma was amazed to know that so many top western scientists and philosophers have drawn a considerable amount of inspiration from ancient scriptures of India, particularly in the studies of modern physics, linguistic and astronomy. In the recent meeting with the author, the Chief Minister had highly appreciated Gewali's book and promised to read it thoroughly. Gewali's book was also approved for translation in the year 2020 by the former Chief Minister – Shri Sarbananda Sonowal but due to COVID-19, the translation work was delayed.

Follow NewsGram on Facebook to stay updated.

Keep Reading Show less

Supporters of the 2022 Beijing Winter Olympics cheer as they mark the start of the 100 days countdown to the opening of the Winter Olympics in Beijing, China, Oct. 26, 2021

BEIJING — Chinese organizers have confirmed participants in next year's Winter Olympics will be strictly isolated from the general population and could face expulsion for violating COVID-19 restrictions.

Vice mayor and Beijing 2022 organizing committee official Zhang Jiandong told reporters Wednesday that those taking part in the games beginning Feb. 4 must remain in a "closed loop" for training, competing, transport, dining and accommodation.

Keep reading... Show less