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Treatment for myeloid leukemia. Pixabay

Researchers have identified two drugs that are potent against acute myeloid leukemia (AML) when combined, but only weakly effective when used alone.

The research team was able to significantly enhance cancer cell death by jointly administering the drugs that are only partially effective when used as single-agent therapies.


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“Our study shows that two types of drugs, MDM2 inhibitors, and BET inhibitors, work synergistically to promote significant anti-leukemia activity,” said researcher Peter Adams, Professor at the Sanford Burnham Prebys Medical Discovery Institute in the US.

“The results were surprising because previous research had shown that each drug on its own had modest benefit against AML. The new research provides a scientific rationale to advance clinical studies of the drug combination in patients with AML,” Adams added in the study published in the journal Nature Communications.


There are many types of AML. Pixabay

There are many types of AML, and different cases have different chromosome changes, gene mutations, and epigenetic modifications, making it difficult for researchers to find novel therapies that will work for a substantial proportion of patients. Although much progress has been made toward finding effective treatments in recent years, the long-term overall survival has stagnated.

According to the American Cancer Society, the five-year survival rate for adults with AML remains less than 30 percent.

Notably, TP53, the most frequently mutated gene in all human cancers, is found unaltered in about 90 percent of AML patients, the researchers said.

Since the product of the TP53 gene, p53, acts to suppress tumors, scientists have sought drugs that reactivate or boost its anti-cancer powers in AML, which should provide a clinical benefit. However, such drugs on their own have been disappointing in AML.

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“We were interested in combining MDM2 and BET inhibitors because each showed encouraging pre-clinical activity, but limited activity when given to patients as a single agent,” said Adams.

“Our research unexpectedly showed that like MDM2 inhibitors, BET inhibitors activate p53, but through a different pathway. BET inhibitors mute the power of a protein called BRD4, which we found is a p53 suppressor in AML for the treatment of Myeloid Leukemia,” Adams added. (IANS)


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Photo by GOI.

On the first day of the two-day meeting of BJP and Rashtriya Swayamsevak Sangh (RSS) leaders on Tuesday, discussions were held on important issues related to education and the National Education Policy-2020

On the first day of the two-day meeting of BJP and Rashtriya Swayamsevak Sangh (RSS) leaders on Tuesday, discussions were held on important issues related to education and the National Education Policy-2020. Apart from senior RSS leader Suresh Soni, representatives of various organisations associated with the Sangh Parivar -- working in the field of education -- were present in the meeting in New Delhi.

According to sources, Union Education Minister Dharmendra Pradhan, who attended the meeting on behalf of the government, shared information related to the National Education Policy-2020 and the government's policy on important issues related to the education sector. Pradhan also shared details of the efforts being made by the government in the field of education.

Discussions were also held regarding the impact of the situation arising out of Corona and how much it has affected the education sector. In the meeting, the RSS leaders asked several questions and provided suggestions to the Union Minister regarding the education policy of the government.

According to the sources, RSS wants the policy to be implemented expeditiously. All aspects related to the policy were discussed in Tuesday's meeting. On the second and the last day of the meeting on Wednesday, special issues related to education will be discussed in which representatives of various organisations of the Sangh, Union Ministers and several BJP leaders will be take part.

Meanwhile, in order to convey its point of view to the government on various issues, the Sangh keeps on calling such coordination meetings related to specific issues, in which RSS representatives -- working in that particular area -- provide feedback to the government. (IANS/JB)


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