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Two Nobel Prize Judges Harriet Wallberg and Anders Hamsten likely to be Dismissed over Stem-cell Doctor Scandal in Stockholm’s Karolinska Institute

The panel that awards the prize is dismissing two judges for their roles in a scandal over disgraced stem cell scientist at Stockholm's Karolinska Institute.

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FILE - Screen showing the Nobel Prize medal during the Nobel Peace Prize ceremony in Oslo, Dec. 10, 2010. Image source: VOA
  • The 50-member panel of judges that awards the Nobel Prize will dismiss two of its judges
  • Karolinska Institute had allegations of scientific misconduct towards the stem-cell scientist Dr. Paolo Macchiarini
  • Macchiarini has been accused of in cases of false conduct too
The panel that awards the Nobel Prize in medicine is dismissing two judges for their roles in a scandal over disgraced stem cell scientist at Stockholm’s Karolinska Institute.

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Nobel Assembly secretary Thomas Perlmann told Swedish news agency TT on Tuesday that Harriet Wallberg and Anders Hamsten would be asked to leave the 50-member group, which will announce the annual award next month.

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Wallberg and Hamsten have already left high-ranking jobs at Karolinska amid scathing criticism of how the institute handled allegations of scientific misconduct against stem-cell scientist Dr. Paolo Macchiarini.

Once considered a pioneer in windpipe transplants, Macchiarini was fired after being accused of falsifying his resume and misrepresenting his work. (VOA)

 

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Consume Low-Fat Diet To Decrease Colon Cancer Risk

High-fat diet may increase risk of developing colon cancer

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High-fat diet
A high-fat diet can lead to the development of colon cancer. Pixabay

Two genes that appear to help stem cells in the intestine burn dietary fat may play a role in colon cancer, according to a new study.

The study, published in the journal Gastroenterology, described a new connection between the way cells consume fat and how genes regulate stem cell behaviour in the intestines of mice.

“This is important because scientists have shown that when there’s too much dietary fat in the intestine, stem cell numbers increase, boosting susceptibility to colon cancer,” said senior author Michael Verzi, associate professor in the Department of Genetics at Rutgers University-New Brunswick.

People naturally lose millions of intestinal cells daily, much like they lose skin cells.

Dietary fat
When there’s too much dietary fat in the intestine, stem cell numbers increase. Pixabay

Intestinal stem cells undergo constant renewal and fuel the continuous turnover of the lining of the intestine, but altered stem cell functions can lead to colon cancer.

Recent studies have shown that intestinal stem cells can increase in animals on a high fat “Western” diet, potentially explaining an elevated cancer risk from such a diet.

The team recently discovered that two genes (HNF4A and HNF4G) work together to promote the proper function of the intestinal lining.

Also Read- Researchers Associate Obesity With Brain Damage

In the new study, they found that mice lost intestinal stem cells when these genes were inactivated, confirming their importance. Scientists believe that the genes help stem cells burn fat, providing them energy.

Going forward, the researchers hope to further investigate whether the two genes alter stem cell numbers and cancer risk during a high fat diet, said Verzi, who is also a member of the Rutgers Center for Lipid Research. (IANS)